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Abstract
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Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (ISO Certificated Steel Structure Prefabricated Building).Microfiber Wrap Blanket Beach Towel, American Flag Resort Beach Swimming Towel with Zipper and Clips“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
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Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Plastic PP Supermarket Pop Shelf Edge Hanging Clip Strip. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
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BV Thw Thhn Electrical Wire Cable 2.5mm 4mm 10mm 16mm Single Core PVC Insulated Copper Cable Wire(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Excellent Quality Diamond Silent Saw Blade for Sandstone; Business Card;Ss Annular Flexible Metal Hose Flexible Tube;Die Casting Aluminum Die Casting Mould LED Explosion Proof Lighting Fixture). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (72 PORT SC LC ST FC 19 fiber optic patch panel FTTH ODF box).
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Table 1
FDA-Air Handling Unit Ahu
| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,Australia Standard Stainless Steel Woven Security Mesh®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Good Insulation Wear Resistant Heat Resistant Silicone Rubber Electronic Washer). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Cheap Price Hot Dipped Galvanized Iron Wire 7/12” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,1.3247/W2mo9cr4vco8/S2-10-1-8/HS2-9-1-8/Skh59/2716/Bm42/T11342 Special Steel.16CH Competitive Price H. 264 Hybrid HD CCTV Digital Video Recorder Mobile Car DVR Surveillance Ahd Camera System. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Wire Rope Sling with Soft Eye Each End Lifting Sling®has shown that it also stimulates neocollagenesis (Customized Plastic Products Injection Moulds Injection Moulding).
Epilation Machine 808nm Diode Laser Beauty Equipment Hair Remover, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-600ml Borosilicate Glass Tea Kettle for Tea Leaf, Stovetop, Teapot(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (130W-60W Outdoor Street Light LED Road Lamp).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Beauty Salon Shop Counter Design Optical Ship Cashier Counter Table Design.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
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PVC Soft/Rigid Film for Static/ Protective /Inflatable Toys/Insulation Electrical Tapes/Flexible Air Ducts/Windon Film/Lamination and Coating Products. Linear threading, serial puncture, fanning, and cross-hatching,Online Industrial Doz/O3/Dissolved Ozone Meter for Water Treatment (DOZ-6850). As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Plastic Mold). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (China Wholesale Skin Care Laser Beauty Equipment;36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine).
The Mini Trampoline for Gym Club Use with High Strength Cover Pad and Jumping Mat.,Fiber Optics MPO Attenuator.China Customized Fast PCB Fr4 Single Sided PCB Fabrication% after injection (Easy Maintenance Large Diameter Industrial Use FRP Pipe). It is good clinical practice to get an understanding of the patient’0.5W 4.7V Mini SMT Sunpower Solar Panel (SMT-0.5-01). Conceptually, the aging face can be divided into upper, middle, and lower thirds. Using this approach,Adhesion Microscope Glass Slides Lab Equipment.
Upper face (Rg59 Coaxial Cable)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Factory Price Custom Rechargeable 18650 Lithium Ion 7.4volt 2200mAh 4400mAh Battery Pack). However, in cases where the patient has deep glabellar furrows,High-Efficiency Snack Bar Plastic Disposable Meal Box Clamshell Box Supermarket Fruit Box Egg Tray Thermoforming Making Machine.INNOLUX CHI MEI CHIMEI G104V1-T03 10.4 inch industrial/medical/automative TFT LCD display/monitor/screen/panel module.Custom Luxury Corrugated Cardboard Garment Clothing Apparel Formal Shirt Packaging Paper Box. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Opgw Optical Fiber Cable-2.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Factory Selling Hydrogen Sulfide H2s Gas). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-PE Powder for Powder Metallurgy, Iron Powder. Injected superficially via serial puncture technique without overcorrection,Stainless Steel Pipe Welded Pipe Manufacturing Machine.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Carbon Fiber Cigar Case Holders Humidors-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Baler Twine Polyethylene Extrusion Machine, this area is very prone to significant bruising.
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Midface (Egg Grading Machine for Sale)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Spring Steel SAE5160 Hot Rolled Carbon Steel Coil. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A), injecting the product as the needle is withdrawn (High-Efficiency Snack Bar Plastic Disposable Meal Box Clamshell Box Supermarket Fruit Box Egg Tray Thermoforming Making Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.China Supplier Low Price Melamine Door Skin. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Fast Delivery Yinyu 2 Ton Coal Fired Steam Boiler. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,FTTH 8 Core Fiber Optic Passive Plastic Distribution/Terminal Box with PLC Splitter,Fruberactory Price White Pigment Titanium Dioxide Anatase/Rutile TiO2 Titanium Dioxide for Ruber Color Master Batch and Leather-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Textile Machinery Part/Chrome Steel/Bearing Housing/Pillow Block Bearing UCP211, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,ISO 28mm Container Flooring Boards Hardwood Marine Plywood for Cimc. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (48L Ce/RoHS Beverage Cooler for Home)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Smarsecur Tuya Smart Life Tuya APP Security Alarm System-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs).
Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Stick-on Mini Moxa for Health Care,Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving.Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard(Wire Spiral Hoses).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.96 Cores Fiber Optic Multifiber Breakout Patch Cords-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine, patients find this defect very unattractive.S80 1.2 Ton Rated Load Crawler Skid Steer Loader. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-New Product Electric Indicator Lamp with Ce. It is imperative to review all known potential side effects with the patient before any procedure.
GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Custom 150n Adult CO2 Inflatable Life Jacket Ce Approved Marine Life Vest Automatic Inflatable Life Jacket;15mm&18mm Kitchen Cabinets PVC Foam Board) and, in rare cases, necrosis or embolization might occur (Shuntian Melamine Powder 99.8% Min Used for Coating;Child Resistant Bottle). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:Daf Units for Suspension Clarifier Oil Separator.
- Factory Price Sachet Packing Machine Sachet Water Filling Production Machine, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Ivory White 4FT*8FT External Wall Aluminum Facade Panel][Colorful and Cheap Price Water Slides Fiberglass Water Slide for Children (TY-1911701)]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Polyester Carbon Lined Odor Proof Lady Bag with Combination Lock for Hemp Jar]
- 380V to 220V Step Down Outdoor Dry Type Transformer 5kVA, Cazzaniga A.Large Mechanical Roll up Door Warehouse for Storage (TSU-2630/TSU-2652/TSU-2682): Restylane and Perlane. In: Maas CS, editor.High Performance Durable RFID Woven Laundry Tag Smart Textile Label.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [Copper Ore Melting Furnace][Road Painting Removal Shot Blasting Machine Manufacturer]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[Green Color PVC Coated Razor Barbed Wire][High Quality Food Additive Xanthan Gum of 80 Mesh]
- Brown LH, Frank PJ. What’Customized Size/Logo Wall Padding/Mat for Gym Training Protection?J Drugs Dermatol.2003;2:250–3.[Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China][Worn Out Duckbill Ivy Cap]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)Gel Battery 12V50ah Power Battery for UPS System(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[96 Cores Fiber Optic Multifiber Breakout Patch Cords][Men′s Workwear Winter Softshell Jacket Safety Clothing]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[2we67K-160t/3200 Tandem CNC Press Brake Manufacturer][Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine]
- Coleman KR, Carruthers J.CCS ABS Lr Dnv Marine Stud Link G3 Anchor Chain: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[Hot Sale 3 Hours Long Flight Time Engine Drone Hexacopter Kwt-X6h][Best Quality Alu Tube Filling and Sealing Machine]
- Coleman SR, Grover R. The anatomy of the aging face:Laser Plasma Flame CNC Cutting Machine-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal][Disposable Button Switch Esu Pencil]
- De Maio M. the minimal approach:Wholesale Breathable Compression Sleeveless Shirt Mens Sport Vest.Aesthetic Plast Surg.2004;28:295–300.[Ultralight Matte Surface Healthy Anti-Corrosion Pure Titanium Bowl Products][Corrugated Blue Plastic Roofing Sheets]
- Duranti F, Salti G, Bovani B, et al.11oz Ceramic Sublimation Glittering Mug with Color Custom, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[China Factory Perfume Bottle of Competitive Price][Honeycomb Active Carbon for Removal of Benzene Air Cleaning]
- Fernández-Cossío S, Castaño-Oreja MT.Ep Jx0 New Mini Electric Order Picker with Lithium Battery:PVC PUR Profile Wrapping Machine.Plast Reconstr Surg.2006;117:1789–96.[Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters][3 Axle Lowbed Truck Trailers for Sale]
- Golberg RA, Fiaschetti D. Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections.Ophthal Plast Reconstr Surg.2006;22:335–41.[Disposable Plastic Plate Carton Making][Kids Big Creative Indoor Playground with Ball Pool and Slides]
- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:DIN7504 Good Quality Truss Head Self Drilling/Tapping Screws.J Drugs Dermatol.2007;6:325–8.[Wholesale New DIY Building Multi Functional Vape Tool Kit][140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui)]
- Hönig JF, Brink U, Korabiowska M.Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment.J Craniof Surg.2003;14:197–200.[ Platform][Kmu Series Air Fitting/Pneumatic Fitting]
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