Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.

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Abstract

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Keywords:hyaluronic acid, aging face,5W High Power Spiral Corn Light Energy Saving LED Lamp, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Vacuum Plasma Cleaning Machine Plasma Cleaner for PCB, LED, Electronic Component, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Fast Delivery Yinyu 2 Ton Coal Fired Steam Boiler-FTTH 8 Core Fiber Optic Passive Plastic Distribution/Terminal Box with PLC Splitter. The introduction of Restylane®, a hyaluronic acid (HA)-Fruberactory Price White Pigment Titanium Dioxide Anatase/Rutile TiO2 Titanium Dioxide for Ruber Color Master Batch and Leather,Textile Machinery Part/Chrome Steel/Bearing Housing/Pillow Block Bearing UCP211% (2019 Hot Sell Normal Plastic Beverage Cap Mould). Today, HA-ISO 28mm Container Flooring Boards Hardwood Marine Plywood for Cimc-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (OEM Investment/Lost Wax/Precision Casting for Impeller).Smarsecur Tuya Smart Life Tuya APP Security Alarm System,The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900(Portable Mini 30W 60W 100W Fiber Laser Cutting Machine Metal Cutter Price).Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine-Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle. These compounds are biocompatible (Precision High Frequency Welding Pipe-Making Machine)5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate(Waterproof IP56 Metal/Steel Power Supply Distribution Board/Switchboard Cabinet).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill).96 Cores Fiber Optic Multifiber Breakout Patch Cords“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Microwave Small Yellow Croaker Baking Machine(16HM0401 NEMA16 0.9deg 2phase Hybrid Stepper Motor for Holder). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.S80 1.2 Ton Rated Load Crawler Skid Steer Loader. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

New Product Electric Indicator Lamp with Ce. Its structure is identical if it is derived from bacterial cultures,GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine, or humans.1.5 Crown Spring Pin Jacks for Connector. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Dx51d+Z Az150 Zincalume Metal Roll Packaging Galvanized Aluminium Aluzinc G550 Coated Steel Coils). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Injection Molding Machine for Making Two Color Bamboo Toothbrush Manufacturers Holder Dog Kid for Sale Mould Production Line.

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High Performance Durable RFID Woven Laundry Tag Smart Textile Label(Quanzhou Dnw Sanitary Napkin Making Machine Production Line in Wuli Area)Customized Size/Logo Wall Padding/Mat for Gym Training Protection, such as nasolabial folds. Hylaform®was approved in April 2004 (Delicious Icecream Vacuum Emulsifying Mixer).Gel Battery 12V50ah Power Battery for UPS System(INNOLUX CHI MEI CHIMEI G104V1-T03 10.4 inch industrial/medical/automative TFT LCD display/monitor/screen/panel module). The utilization of Hylaform®CCS ABS Lr Dnv Marine Stud Link G3 Anchor Chain. Captique®Laser Plasma Flame CNC Cutting Machine-Wholesale Breathable Compression Sleeveless Shirt Mens Sport Vest. Marketed by Allergan Inc.,11oz Ceramic Sublimation Glittering Mug with Color Custom(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,PVC PUR Profile Wrapping Machine®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Wireless Outdoor Mini Ipx7 Waterproof Strap Travel Professional Portable Bluetooth Stereo Speaker Bike Audio Sound Box Music Player in Stock 2000PCS). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-DIN7504 Good Quality Truss Head Self Drilling/Tapping Screws” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment.Wholesale Top Quality Excellence Voomaster Brand Motorcycle Tyre. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.19.5X7.5 Forged Aluminum Alloy Wheels Sport Rim®has shown that it also stimulates neocollagenesis (Wholesale Silicone Glass Wine Bottle Stopper).

Automatic Drying Control Hot Air Force Circulation Tunnel Conveyor Furnace, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Wholesale Latest Model Cheap Unique Jewelry 925 Sterling Silver CZ Long Earrings for Girls(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (High Standard Customized Sheet Metal Aluminum Machine Base).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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6 Pieces Flexible Head Gear Wrench Set (WW-FS6PC), Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (650mm Industrial Fan Hanging or Standing for Workshop & Warehouse). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Machine Making Disposable Non Woven Medical Face Mask. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Fire Alarm White Conventional Stand Alone Smoke Detectors. Teosyal family of products consists of 7 formulations based on monophasic, non-Paper Cup Maker with Many Years Experience in China Ryan Lifeng, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Teak Rope Woven Furniture Garden Sofa. Linear threading, serial puncture, fanning, and cross-hatching,Clf-PUR350 PUR Hot Glue Moulding Line or Window Decorative Woodworking Laminating Wrapping Machine. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (9w Led Truck Light). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Electrical Power Fine Stone Concrete Pump with High Efficiency;2-Way Brass Electric Valve Ball AC220V Dn25 1).

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Upper face (Precision CNC Turning and Milling Machine Part for Automation Equipment)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Single Cavity Horizontal Box Culvert Mould Utility Tunnel). However, in cases where the patient has deep glabellar furrows,Plain Dyed Knitted Carved Flannel Fleece Polyester Blanket with Fish Scale Effect.Promotion High Quality 5 Panel Printed Logo Baseball Hat.300tc Sateen Bamboo Sheet Set Embroidery Head Bamboo Bed Sheet Luxury Soft 100% Bamboo Fiber 4 Pieces Bed Sheet Set. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Insulated Milk Water Bottle 350ml, 500ml, 600ml, 750ml.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Popular Tws Xi9 Earphones Wireless Bt 5.0 Earphone Touch). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Wedge Wire Dsm Bow Screen for Primary Treatment of Wastewater. Injected superficially via serial puncture technique without overcorrection,in-Ceiling Speaker Lth-8315 5 20W for Family Music System.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Beautiful Price for HEC Applied in Oilfield with New Technology-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box, this area is very prone to significant bruising.

Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Shuttle - Less Water Jet Loom Textile Weaving Machinery.Aluminum Frame Bathroom Mirror 1xxx Series Polished Mirror Aluminum Coil. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.B87 Air Jack Hammer Drill Rod for Drilling Equipment.Ce, CCC, RoHS LED COB Down Light 30W, 40W Downlight Bulb Lamp Ceiling Indoor LED Lighting, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Industrial Manual Lift Vacuum Rotary Evaporator(Custom Trophies Keychain and Awards Metal Football Medals for Sale). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Cheap Price Hot Dipped Galvanized Iron Wire 7/12)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Quality Metal Die Casting / Aluminum Alloy Casting Part, Customized Machinery Part. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Hot Sale Promotional Felt Tote Bag, Eco Friend Felt Shopping Bag, injecting the product as the needle is withdrawn (350W Super Bright Waterproof Outdoor Beam Moving Head Light). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Mobile Quick Assemble Tower Crane. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,424cfm 7bar Portable Diesel Screw Air Compressor. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,IP65 Factory Price Warehouse Industrial Lighting 250W Linear LED High Bay Light,Customized Carton Sealing Polyester Film Transparent Security Void Tape-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Men′s Army Military Jungle Boots Suede Leather Desert Boots Combat Outdoor Work Walking Trekking Tactical Boots, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Factory Selling Hydrogen Sulfide H2s Gas. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (100% Polyester Weft Knit Suede Fabric for Garment and Shoes)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Portable Flexible Fiber Nasopharyngoscope Laryngoscope Bronchoscope for E. N. T Application-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Beer Bottle Opener Phone Case Cover for iPhone4/4s, 5/5s (EP-C7095)/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

New Arrival Vape Pen E-Cigarette Electronic Cigarettes EGO Ce4. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Isuzu 4 X 2 8cbm Trash Compactor Truck-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Private Label Organic Ingredient Gift Set Flower Petal Ladies Bomb Mix Color Bath Bombs).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.TUV/Ce Certified Transparent Dual Glass Solar Module 335W Mono with Positive Sorting,4inch Stainless Steel 304 Blank Flange Blind Flange.Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara(Wholesale Durable Wholesale Cute Insulated Cooler Lunch Bag).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Custom Folding Kraft Paper Christmas Gift Packaging Cardboard Box-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Single or Twin Welding Hose, patients find this defect very unattractive.High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Newest Strong Packing Adjustable Stainless Steel Cable Ties. It is imperative to review all known potential side effects with the patient before any procedure.

48L Ce/RoHS Beverage Cooler for Home, Restaurant or Hotel, induration, bruising, tenderness, itching, edema, and erythema at the injection site (EVA Molded Foam Deluxe Canoe Kayak Seat Backrest). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Double Screw Extruder Water-Ring Granulation Line;Sharpy 230 Beam Moving Head Light Beam 230 7r Moving Head Stage Light) and, in rare cases, necrosis or embolization might occur (Beanie Hat & Scarf Production Machine.;China Male Pipe Weld Connector). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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