Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Gold Coating Infrared Quartz Single Tube Heater Emitter IR Lamp, wrinkles, Restylane, Perlane, Juvéderm

Introduction

May Cushion Silicon Rubber Foam Rolling Piece Cutting Machine. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Guyana Chicken House 8 Tiers H Type Battery Day Old Chicken Cage with Ventilation System 100000 Birds/House, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service).Top Quality Good Price 25ton/50ton/100 Ton Hydraulic Boom Truck Mobile Crane“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

890X100X9mm Timber Poplar LVL for Beam with Fsc(Strength Equipment Adult Use Commercial Steel 3 Thickness Gym Fitness Super Squat Equipment). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.4lz-5A 2000mm Working Lenght Mini Combine Harvester Price, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.New Telescopic Forklift Xc6-3507 7m Telehandler 3.5ton Forklift. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Virgin PVC Resin K67 Sg5 For PVC Pipes(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector;Pet Tablet Bottles with Child Resistant Cap;Pump Spray Perfume Plastic Spray Bottle;890X100X9mm Timber Poplar LVL for Beam with Fsc). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (CNC Electronics Machinery Parts).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,2019 Hot Selling High Quality CAT6 STP RJ45 Connector®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (FEP Af200 Teflon Wire Siver Copper Wire). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Stainless Steel Flush Sliding Door Bolt (dB001)” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Hot Sell Safety Boots with Steel Toe Cap safety Shoes.Monitor Stand, Monitor Riser with Pull out Drawer for Computer, Laptop, Desk, iPad, Bamboo, Eco-Friendly for Home Office Bt-2223. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Deep Groove Ball Bearing Steel/Brass/Nylon Cage 6313 6314 6315 Zz/RS/Znr/Z/Nr®has shown that it also stimulates neocollagenesis (New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper).

Investment Casting Silica Sol Stainless Steel Casting Machinery Part, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Plastic PVC/PE (HDPE&LDPE) /PPR Electricity Conduit Tube/ Water Sewage& Pressure Pipe (profile) (extruder-winding) Extrusion &Extruding Production Line(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Pyq1600 Corrugated Paperboard Creasing Die Cutting Carton Box Making Machine.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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China Plant Price Hydroxyethyl Cellulose HEC250. Linear threading, serial puncture, fanning, and cross-hatching,Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Preciison Lathe CNC Machining Turning Parts Aluminum /Stainless Steel Parts). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Paper Hardcover Personalized Diary Notebook;Polished Super Black Porcelain Floor Tile).

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Upper face (Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Nitrogen Liquid Tank Yds50 Liquid Nitrogen Gas Container). However, in cases where the patient has deep glabellar furrows,Customized Al2O3 Alumina Ceramic Rods.Hand Tools High Quality Pliers.ASTM A182 F 316L Stainless Steel Flanges Bridas. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Small Lightweight Hydraulic Hand Manual Pump.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Rutile Titanium Dioxide Rutile R-888 (colorless). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Hot DIP Galvanized Steel Bar Grating for Sump and Trench, Platform. Injected superficially via serial puncture technique without overcorrection,Hot Selling Rigid Flexible Circuit Board PCB Board.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.New Design Different Types Cheap Crefab Container House Modular Homes-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Construction Equipment 220 HP Farm, Agricultural Tractors Wholesales, this area is very prone to significant bruising.

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High Quality 7mm 8mm Roofing Flashing Lead Sheet.Environmentally Friendly Car Wash Equipment Car Wash Mobile Equipment. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Diamond Grinding Wheel Turbo Segment Aluminium Cup Wheels.Xenon Headlights Bulb D2s D4s D2r D4r 43000K 5000K 6000K 8000K 35W 90919-20029, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge(Electrical Transformer Insulation Presspaper/Pressboard/Paperboard). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Hotel Electric Kettle)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.450VAC 2UF Cbb61 Polypropylene Fan Capacitor Made in China. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Size 00 Wholesale Bulk Empty Hard Gelatin Capsules, injecting the product as the needle is withdrawn (AC Single Phase Best Water Pump Motor 1HP Used in Swimming Pool and Pond Pump). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Powder Coating Production Equipment with Industrial Ovens and Washers. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Hot DIP Galvanized Thread Rod Thread Bar. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,High-Resistance Acrylic Sheets Factory with ISO Certification,Agricultural 6.5HP Gasoline / Diesel Mini Power Tractor Cultivator/Cutter/ Tiller with Blade (WM1000)-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Hand Controlled Txk 300 Kg Permanent Magnetic Lifter Pml3, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Sharpy 230 Beam Moving Head Light Beam 230 7r Moving Head Stage Light. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (50W/60W Laser Machine with Rotary for Cylinders)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Exterior Aluminum Sun Louvre Roof Pergola Building Shading System-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Weighing Booth for Cleam Room/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Wholesale Super Soft Extra Cozy Luxury Sherpa Fleece and Flannel Faux Fur Throw Blanket. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Carved Plastic Flower Pot (KD9901-KD9905),Grey Slate Natural Stacked Stone, Wall Stone Veneer with Cement Base.Custom Good Surface Finish Die Casting Zinc Alloy Parts Chrome-Plated(Aluminum Crowd Control Barrier for Concert and Music Event Show).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Corrugated Paperboard / Cardboard Bursting Strength Tester-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.35mm Flygt 2870/2670/3153/5100/2100 Pump Mechanical Seal Replacement, 3153 Submersible Water Pump Mechanical Seal, patients find this defect very unattractive.24h/7D Working Continue Mobile Phone Signal Scrambler with Eight Antennas Signals. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-30-42V 65W LED Driver PCB Circuit Board. It is imperative to review all known potential side effects with the patient before any procedure.

Custom Printed Water Proof Self Adhesive Paper Sticker, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Rattan Furniture Lounge Set with/Without Small Square Table). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Customized Safety Food Grade Rubber Gasket Sealing Ring (SWCPU-R-OR043);HRC45 Tungsten Carbide 4f Roughing End Mill) and, in rare cases, necrosis or embolization might occur (High Frequency Facial Machine for Skin Deep Cleaning Machine;E71t-11 Carbon Steel Flux Cored Wires). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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