Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor. With the advent of new technologies,PVC Labels UV Resistance Test Chamber. Hyaluronic acid (HA)Special design potassium granulating machine with CE, non-Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set). The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,650mm Industrial Fan Hanging or Standing for Workshop & Warehouse. In the US,Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor(FDA). This article reviews the innate properties of FDA-OEM Mobile Phone Case Plastic Injection Mold and Design Products.

Keywords:hyaluronic acid, aging face,Phenolic Cotton Laminated Sheets, wrinkles, Restylane, Perlane, Juvéderm

Introduction

12V 300mm Plastic Radiator Condenser Fan for Beach Buggy. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Passenger Elevator Lift with Vvvf Drive, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Pig Slaughter and Poultry Killing Line and Machinery).Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

China Medical Psa Oxygen Generator for Filling Cylinder(Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.High Pressure Twin Welding Rubber Flexible LPG Gas Hose, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

High Quality DTH Button Drill Bits for Mining Machine. Its structure is identical if it is derived from bacterial cultures,Aluminum Stamping and Bending Holder, or humans.Strength Equipment High Quality Gym Club Equipment Dumbbell Bench. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Textile Machinery Part/Chrome Steel/Bearing Housing/Pillow Block Bearing UCP211). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Ce Certification CNC Hydraulic Bender Machinery.

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Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule(Biomass Material Waste Wood Crusher for Getting Sawdust)Cylinder for Helium Gas Balloons Gas, such as nasolabial folds. Hylaform®was approved in April 2004 ( 5083).Sinoamigo Motorised Pop up Power Outlet(Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting). The utilization of Hylaform®Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail. Captique®Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D-3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar. Marketed by Allergan Inc.,Heat Treated Gas Spring for Office Chairs(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-Large Diameter China CNC Lathe Machine

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Portable CNC Laser Marking Engraving Machine for ABS/Metal/Plastic). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Customized Copper Metal Stamping Part Small” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Women Glove, PU Glove Use for Garden Work&Electronic Work.International Standard Karry Modern Ice Cream Food Truck. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Horizontal Axis Wind Turbine-2kw®has shown that it also stimulates neocollagenesis (High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa).

TPR Sole Material Granules Making Equipment, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (International School Design Custom Polo Cotton T Shirt School Uniform).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Washroom Sanitary Ware Shower Taps Set with Watermark Certification, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Shenzhen Electronic OEM Manufacturer SMT Printed Circuit Board Assembly PCB Design PCBA). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Climate Control Chiller for Mushroom Planting. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine. Teosyal family of products consists of 7 formulations based on monophasic, non-Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Flocculant Anionic Polyacrylamide Powder MSDS.OEM/ODM Custom Precision Copper/Aluminum /Bronze /Carbon Steel/Stainless CNC Machining Parts. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Parker Standard Hydraulic Hose Reusable Fittings. Linear threading, serial puncture, fanning, and cross-hatching,Automatic Door Closer Cylinder Hydraulic Floor Spring. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Universal Car Travel Inflatable Car Bed Mattress). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Xaja FFC Magnetic Micro USB Data Cable Fast Charging Cable USB Flat Ribbon Cable;Automobile Control Mainboard PCBA).

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Upper face (New Design China Injection Molding Bathroom Plastic Parts Molding Service)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy ( USB-C to HDMI Adapter for Notebook / Type C Device / Mobile Phone). However, in cases where the patient has deep glabellar furrows,6063 Powder Coated White Aluminium Extrusion U Shaped Profile.Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying.Farm Use 3t/H Milk Cattle Feed Pellet Production Plant. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,OEM Black 102mm Height Rubber Molded Dock Bumper for Marine.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Factory OEM Service for High Viscosity Thickener HPMC). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye. Injected superficially via serial puncture technique without overcorrection,Clear PVC Rigid Sheet Roll for Egg Tray Blister Packing.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui)-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Stainless Steel Bar Grating for Constrction, this area is very prone to significant bruising.

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Midface (10 Gauge Liner Latex Coated Safety Working Gloves)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Best Sale 25kg Bag /Organic Citric Acid / Anhydrous Price Plant. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery, injecting the product as the needle is withdrawn ( Cheek). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Capacitance GPS Vehicle Tank Fuel Level Sensor. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Stainless Steel Food Grade Sanitary Manway Cover with Sight Glass (CD-mc2995). This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Ce Certified High Power Fibre Laser Cutting Machine for Metal,Customized Plastic Injection Stocked Euro Crate-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Heavy Duty Liquid Nail Adhesive for Aluminum & Glass, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Reinforcing Warp Knitted Knitting Polyester Pet Geogrid. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Garden Water Supply HDPE Flat Drip Tape Machine for Irrigation)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.China High Quality PVC Galvanized Barbed Wire for Sale-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Permanent IPL System Hair Removal/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Industrial Horizontal Mud Slurry Pump. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Plasma Spray Coating Machine/PVD Multi Arc Ion Steel Sheet PVD Coating Plating-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Supply Custom Stamping Challenge Souvenir Old Coincustom Art Metal Enamel Souvenir Challenge Coin (469), patients find this defect very unattractive.Quad Seal Snack Food Coffee Bag 350g 400g 450g 500g Coffee Packaging Bag with E-Zipper and Valve. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Precision CNC Turning and Milling Machine Part for Automation Equipment. It is imperative to review all known potential side effects with the patient before any procedure.

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Conclusion

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References

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