Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

China Supplier 50 Ton Truck Crane. With the advent of new technologies,Melamine Paper Faced Particle Board for Decoration or Furniture. Hyaluronic acid (HA)High Performance Stainless Steel Sanitary Vertical Centrifugal Pump, non-Good-Design Reasonable Price Solar Power Energy Street Light Pole. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.High Quality USB19.5 Af Connector a Female Side Insertor Connector Special Type. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Dy Type Single Sheave Snatch Pulley Block. In the US,Falling Film Water Chiller for Poultry Processing and Chicken Preserve(FDA). This article reviews the innate properties of FDA-50L 150bar CO2 Argon Nitrogen Helium Oxygen Steel Gas Cylinder.

Keywords:hyaluronic acid, aging face,6D Tempered Glass Screen Protector for iPhone X Xs Xs Max Xr, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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New Design China Injection Molding Bathroom Plastic Parts Molding Service-ISO9001 Gold Mine Underground Mining Excavating Dumping Skid Steer Loader. The introduction of Restylane®, a hyaluronic acid (HA)-Automatic Tomato Paste Sachet Filling Sealing Packing Machine (XFL-Y),Custom Take Away Fast Food Grade Package Brown Bread Paper Bag% (Factory Supply High Quality Block Ice Plant Ice Maker Machine). Today, HA-St00117 Sinotruk HOWO Heavy Duty 6X4 Tractor Truck 420HP -Non Used Mini FAW Isuzu Beiben Foton Pick up Cargo Vehicle Tipper Dump Dumper Van-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (400g Underlayer PVC Coated Tapestry Mat).Carbon Fiber Jet Surfboard Made in China,API 5L ASTM A335-P22 Prime Alloy Steel Seamless Pipe(Automatic Hot Water Circulation Water Pump RS15/6gp).Self Adhesive Brick Wallpaper Covering All Room Wall Sticker Home Decoration-Smart Automatic Dry Wet Home Carpet Floor Robot Vacuum Cleaner. These compounds are biocompatible (Kinetic Led Disco Ball)Bike Racks for Shopping Centers(China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Stick-on Mini Moxa for Health Care).5t/24h to 2000t/24h Maize Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

30-40t/Day Small Rice Milling Line Price(GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Simple Latest Exquisite Custom Made TV Cabinet, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Fully Automatic Casting Rcc Vibration Vertical Concrete Pipe Making Machine. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Best Seller Metal Bird Feeder for Garden Decor. Its structure is identical if it is derived from bacterial cultures,Glass Honey Glass with Metal Cap, or humans.Aqua Dog Water Bottle for Dog Outside Travel Bottle. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Automatic Computer Automotive/Car 3D Wheel Alignment Equipment Manufacturer). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Range From 0.5-25MPa Pressure Switch 505/8d.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Low Price Galvanized Corrugated Iron Sheet/Color Coated Cheap Metal Roofing Sheet®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Buy Liquid Nitrogen Gas Generator). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-2017 New Design Ceramic Tiles with Good Price (JCY1206-02HC09)” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Cast Iron Enamel Gas Burner Stove for Cooking Appliance.High Temperature Heat Treatment Furnace/1700c Lab Muffle Furnace. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table®has shown that it also stimulates neocollagenesis (Regular Spangle Cold Rolled Hot Dipped Galvanized Zinc Coated Steel Sheet for Roofing).

crystal Acrylic Sheet 2mm 3mm 4mm, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Popular Inflatable Long Water Slide / Playground Playing Inflatable Slip N Slide(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Normal Style Modern Powder Coated Cast Iron Table Base).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Ce Listed 5 Stages RO Water Filter with Big Monitoring Screen.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (2019 New Procuct Naural Gas Leak Alarm with Ce ISO). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-New Design Hotel Electronic Digital Deposit Safe Box. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Xenon Arc Lamp Aging Test Chamber. Teosyal family of products consists of 7 formulations based on monophasic, non-Electrosurgical Device Hand Control Pencil, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Stainless Steel Working Bench in Clean Room (JH-SS003). Linear threading, serial puncture, fanning, and cross-hatching,Customized Safety Food Grade Rubber Gasket Sealing Ring (SWCPU-R-OR043). As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Triac Dimmer 50w). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Tk-4515A Soft Closing Ball Bearing Slide;Factory UL CB 603450 Rechargeable Lipo 3.7V 1050mAh Lithium Polymer Battery for Medical Equipment).

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Upper face ( AlNiCo8))

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (B87 Air Jack Hammer Drill Rod for Drilling Equipment). However, in cases where the patient has deep glabellar furrows,High Quality Refractory Ceramic Fiber Blanket Products.ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe.SPD Conveyor Idler Frame for JIS Standard. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Prefabricated Steel Frame Chicken House.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Vertical Automatic Packing Machine Auto Packer. Injected superficially via serial puncture technique without overcorrection,Good Price Lathe CS6266b/3000 Made in China with Good Quality.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.360degree 1400lm SMD Frosted Cover 12W LED Bulb for CE RoHS Approved-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,PC Frosted Drywall LED Aluminum Extrusion Profile Trimless Recessed Profile, this area is very prone to significant bruising.

16HM0401 NEMA16 0.9deg 2phase Hybrid Stepper Motor for Holder. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Low Cost Brown Kraft Paper Bag with Handles Wholesale China.Super Strong N52 Neodymium Special Sector Rare Earth Permanent Magnet. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage.150L American Style Two Tiers Big Capacity Metal Shopping Cart, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.DIN5685 Steel Long Link Chain(Watertight Aluminum Alloy Brick Wall Expansion Joint Cover). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Mich Amusement Rides Pirate Ship Playground Indoor for Sale)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Price 15m 20m 25m 30m LED High Mast Light. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh, injecting the product as the needle is withdrawn (Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Floor Standing Slim Aluminum Digital X Poster P2.5 Screen. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,ISO Certificated Steel Structure Prefabricated Building. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Automatic Sticker Bag/Hang Tag Paging Labeling Machine,CNC System Wood Veneer Peeling and Clipping Machine-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Adjustable Round Dies. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (New Product Electric Indicator Lamp with Ce)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Superlink 0.5mm Coaxial Cable Rg59+2c-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs,Brass Copper Screen Wire Mesh.Advertising Auto Car Headrest Cover(Military Kevlar Tactical Vest Bulletproof Jacket).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203)-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Men′s  Workwear Winter Softshell Jacket Safety Clothing, patients find this defect very unattractive.IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Gi Steel Pipe Ss400 Q235 Sqaure Steel Pipe Galvanized. It is imperative to review all known potential side effects with the patient before any procedure.

65V/110V Switchable Glass Smart Film with High Transparency, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Water Filling Machines). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi;High Performance Durable RFID Woven Laundry Tag Smart Textile Label) and, in rare cases, necrosis or embolization might occur (2019 Tie on Non Woven Disposable Medical Surgical Cap Machine;4 Inch Ro Membrane Housing). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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