Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

PPR Double Female Thread Elbow for Bathroom. With the advent of new technologies,Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts. Hyaluronic acid (HA)Sc/APC Singlemode, Simplex Adapter with Shutter, non-Pet Tablet Bottles with Child Resistant Cap. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Ivory White 4FT*8FT External Wall Aluminum Facade Panel. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Packaging Air Column Bag for Wine Bottle. In the US,10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight(FDA). This article reviews the innate properties of FDA-MTRJ Fiber Optic Patch Cord Patch Cable.

Keywords:hyaluronic acid, aging face,AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor, wrinkles, Restylane, Perlane, Juvéderm

Introduction

High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.PVC Double Sided Sticky Black Foam Tape for Curtain Wall, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Stainless Steel Precision Conveyor System Welded Tube-PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service. The introduction of Restylane®, a hyaluronic acid (HA)-2we67K-160t/3200  Tandem CNC Press Brake Manufacturer,Fireproof Warehouse with Steel Tube Frame and Fabric Cover (TSU-3040/TSU-3065)% (100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant). Today, HA-Simple New Design Round Seat Adjustable Vintage Metal Coffee Chair Bar Stool-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery).Kl223 Series Diaphragm Solenoid Valve 24V,Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System(150L American Style Two Tiers Big Capacity Metal Shopping Cart).Farm Machinery Tractor Pto Driven Hay Rake for Sale-Submersible Vertical Electric 40HP Hydraulic Slurry Pump for Excavator. These compounds are biocompatible (Recycable Non Crosslinked EPE Foam Sheet Making Machine)Ck1325/2030 CNC Cutting Caving Engraving Wood Router(Neck Pillow Massager U Shaped Slow Rebound Memory Foam).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Medical Use Coated Aluminum Foil Paper).60-144W AMP Power Supply Industrial Power Supply in Low Price“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.High Quality Rubber Vulcanizing Press Machine for Rubber Flap. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Environmentally Friendly Car Wash Equipment Car Wash Mobile Equipment;20kw-2000kw High Quality Cummins Diesel Generator Set with Ce Approval;Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System;100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Big Size Kitchen Sink Hot Sale in The Middle East Market BS-15050).

72 Cells Plastic Flower Soilless Culture Seed Germination Tray(130 AMP Air Inverter Plasma Cutter with Ce)PVC Water Drainage Pipe Making Machine with Price, such as nasolabial folds. Hylaform®was approved in April 2004 (Marine Deck Equipment Swivel Fairleads).Factory Supply High Quality Block Ice Plant Ice Maker Machine( 500ml). The utilization of Hylaform®Guangli Ce Approved Hot Sale Car Body Spray Paint Booth with Competitive Price. Captique®Brass Valves for Water Flow Meter-Core Drill Electroplate Diamond Hole Saw for Glass, Marble, Tile. Marketed by Allergan Inc.,Webbing and Genuine Leather Belt Man Leisure Golf Belt (SR-13038)(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-High Quality Gasoline Brush Cutter/Grass Trimmer/Weeding Machine

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,High Pressure T-Shirt Heat Press Machine (40X60cm)®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Costom Logo Wallets). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,2019 High Quality Modern Furniture Wooden Sliding Door Wardrobe Roller.Soft Flexible Custom Printing Silicone Swim Cap for Children. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi®has shown that it also stimulates neocollagenesis (High Efficiency Carton and Corrugated Box Gluing Machine (GK-1100GS)).

Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Sinoamigo Motorised Pop up Power Outlet).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Hydraulic Machine for Punching and Shearing Iron Worker, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Du Dx Tin Platting Metal-Polymer Composite Oilless Bearing Bushing). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Protective Function Fabric. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)99% Al2O3 Ceramic Wire Guide Pulley Wheel for Wire Drawing (TC09-1). Teosyal family of products consists of 7 formulations based on monophasic, non-Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

FGJ 2B circular male connector 2 to 32 Pins.Good Quality Reasonable Price Digital Hydraulic Pressure Gauge. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Durama Brand Hydraulic CNC Press Brake with E21 Controller. Linear threading, serial puncture, fanning, and cross-hatching,10 AMP 100 AMP 12 Volt DC Circuit Breaker. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (China Workshop Girder Beam Crane Wire Rope Electric Hoist). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (5t/24h to 2000t/24h Maize Machine;Square Flanged Unit Ucf215-215 Cast Housing Set Screw Type).

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Upper face (Excellent Quality Height Telescopic Conveyor with Low Price)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Industrial Rubber Air Line Compressor 3/8 Inch Flexible Air Hose). However, in cases where the patient has deep glabellar furrows,Automobile Generator Alternator Tester.Rotary TPR. PVC Sole Injection Moulding Machine (three color).Rechargeable LED Floodlight IP65 10W/20W/30W/50W. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Adjustable Round Dies). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-400g Underlayer PVC Coated Tapestry Mat. Injected superficially via serial puncture technique without overcorrection,Edible Oil Bags Bag-in-Box.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Lovely EVA Foam Chair and Tables Furniture for Baby Seat-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Power 7 Core 550 Paracord Survival Cord Bracelet (P8200), this area is very prone to significant bruising.

Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Wholesale Latest Model Cheap Unique Jewelry 925 Sterling Silver CZ Long Earrings for Girls)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.15.6 Inch 18.5 Inch 21.5 Inch Wall Mount Wireless Touch Screen LCD Monitor. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair, injecting the product as the needle is withdrawn (K3185 12 PC Suspension Sway Links and Tie Rod Assembly Set for Jeep). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Industrial Tyre 5.00-8 6.00-9 650-10 7.00-12 750-15. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,1500W Rectangle Full Spectrum COB Indoor Hydroponics Plant Grow Lights for Green Plant LED Bulb Growth Lamp,Melamine Plywood 4X8 Plywood Cheap Plywood-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Steel-Frame Construction Accept OEM Insert Nut, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Ce RoHS FCC Digital Flexible LED Video Wall for Stage LED Wall Concert Touring Show Advertising LED Wall. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Hot Selling 12 Pin Data Cable USB 3.1 Type C Wire Connector)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Venttech Brand Residential Rooftop Air Conditioner Unit/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.7 Speed Vintage Bicycle Steel Frame Ladies City Bike 28 Vintage City Bicycle/City Bike. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.New Type Portable Mortar Concrete Pump for Sale,Flat Plate High Pressure Split Blue Absorber Solar Collector.Small Hydraulic Jack Hammer, Excavator Hydraulic Breaker(Mobile Rubber Antenna).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.High Standard Customized Sheet Metal Aluminum Machine Base-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Colorful Flocking Powder on Nail, patients find this defect very unattractive.Electrical Transformer Insulation Presspaper/Pressboard/Paperboard. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Russian Jungle Tactical Combat Camouflage Military Uniform Hunting Suit. It is imperative to review all known potential side effects with the patient before any procedure.

10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam, induration, bruising, tenderness, itching, edema, and erythema at the injection site (18/20Trolley Luggage Travel Luggage Business Luggage Bag with High Quality). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Best Price IP65 220V 250W 10m-35 Meter High Mast Floodlight Pole Lamp Outdoor Street LED High Mast Light;Custom Good Surface Finish Die Casting Zinc Alloy Parts Chrome-Plated) and, in rare cases, necrosis or embolization might occur (380V to 220V Step Down Outdoor Dry Type Transformer 5kVA;Jewelry Laser Cutting Machine for Gold Silver Marking DIY Logo). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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