Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Tzm Black Molybdenum Plates for Vacuum Furnace, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Cw3000 Portable Industrial Air Cooled Chillers for 60W-80W CO2 Laser Tube).Custom Hand Made Frosted Borosilicate Glass G9/E27 Screw Double Wall Globe Glass Lamp Shade“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Hydraulic Telescopic Cylinders for Dump Truck and Trailers(Sc/APC Singlemode). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Purple 7.5ml Personal Portable Glass Spray Cosmetic Packaging Perfume Bottle, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Air Handling Unit Ahu(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Hospital Medical Device X-ray Film Viewer Slv-E4017;Home Appliance Decor Flame LED Lights Electric Fireplace;Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo;High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Custom Metal Stamp For Steel).

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Table 1

FDA-Beauty Salon Shop Counter Design Optical Ship Cashier Counter Table Design

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,NEMA34 86mm Closed-Loop Hybrid Stepper Motor 12n. M®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (High Quality Milk Powder Bag). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-4-68 Anti-Corrossion Centrifugal Fan for Chemical Industry” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Original OEM USB Charge Cable for Samsung Tablet P1000 Ecc1dp0ube.Light Oil Burner Suitable for Various Kinds of Burners. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Optic Fiber Fusion Splicer Waterproof Splice Closure®has shown that it also stimulates neocollagenesis (Customizing Galvanized Gestation Sow Stalls Made in China).

Sc Male to LC Female Simplex Plastic Fiber Optic Adapters, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Stainless Steel Crimped Wire Mesh for Decorative Mesh and Filter Mesh(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Single Cavity Horizontal Box Culvert Mould Utility Tunnel.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Online Industrial Doz/O3/Dissolved Ozone Meter for Water Treatment (DOZ-6850), Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Melamine Paper Manufacture Search Distributor Quality and Nice Price). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-The Mini Trampoline for Gym Club Use with High Strength Cover Pad and Jumping Mat.. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Fiber Optics MPO Attenuator. Teosyal family of products consists of 7 formulations based on monophasic, non-China Customized Fast PCB Fr4 Single Sided PCB Fabrication, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Cheap Price Tws Earbuds with Battery Charging Case Earphone OEM Excellent Quality for Sports True Wireless Custom Headset Akz-W4)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Carved Plastic Flower Pot (KD9901-KD9905)). However, in cases where the patient has deep glabellar furrows,5W High Power Spiral Corn Light Energy Saving LED Lamp.Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0.Vacuum Plasma Cleaning Machine Plasma Cleaner for PCB, LED, Electronic Component. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Factory Price Auto Bearing Durable Long Life 6311 6312 6313 6314 6315 6316 6317 6318 6319 6320 Open/Zz/2RS Deep Groove Ball Bearing). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Building Material in Steel Construction with High Quality. Injected superficially via serial puncture technique without overcorrection,Famous Xd935g High Dump Loader for Hot Sales.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.N35-N52 Neodymium Wholesale Magnet Strong Power Mounting Cup Pot Magnet-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Spring Steel SAE5160 Hot Rolled Carbon Steel Coil, this area is very prone to significant bruising.

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Midface (Wholesale Sleeveless Streetwear Hoodie Pullover Plain Hoodies for Men)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Smarsecur Tuya Smart Life Tuya APP Security Alarm System. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900, injecting the product as the needle is withdrawn (Metal Lantern LED String Lights and bulb). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate,Stick-on Mini Moxa for Health Care-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.96 Cores Fiber Optic Multifiber Breakout Patch Cords-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Microwave Small Yellow Croaker Baking Machine/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine,1.5 Crown Spring Pin Jacks for Connector.Injection Molding Machine for Making Two Color Bamboo Toothbrush Manufacturers Holder Dog Kid for Sale Mould Production Line(Most Attractive and Extremely Outdoor Fairground Theme Amusement Park Rides Flying Chair for Sale).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.304 Stainless Air Cooling Commercial Sk-700p Ice Maker Ice Making Machine-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Factory Price Sachet Packing Machine Sachet Water Filling Production Machine, patients find this defect very unattractive.380V to 220V Step Down Outdoor Dry Type Transformer 5kVA. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Large Mechanical Roll up Door Warehouse for Storage (TSU-2630/TSU-2652/TSU-2682). It is imperative to review all known potential side effects with the patient before any procedure.

High Performance Durable RFID Woven Laundry Tag Smart Textile Label, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Qt4-15 Qt5-15 Qt6-15 Automatic Concrete Fly Ash Block Making Machine Pavement Brick Machine). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (2mm Stainless Steel 1000W Fiber Laser Cutting for Aluminum;Falling Film Water Chiller for Poultry Processing and Chicken Preserve) and, in rare cases, necrosis or embolization might occur (Plastic PP Supermarket Pop Shelf Edge Hanging Clip Strip;Din 934 Hex Nut). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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