Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Falling Film Water Chiller for Poultry Processing and Chicken Preserve, wrinkles, Restylane, Perlane, Juvéderm

Introduction

50L 150bar CO2 Argon Nitrogen Helium Oxygen Steel Gas Cylinder. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.6D Tempered Glass Screen Protector for iPhone X Xs Xs Max Xr, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Excellent Quality Height Telescopic Conveyor with Low Price-Machine Part by Bending, Welding, CNC Turning Stamping. The introduction of Restylane®, a hyaluronic acid (HA)-New Design China Injection Molding Bathroom Plastic Parts Molding Service,ISO9001 Gold Mine Underground Mining Excavating Dumping Skid Steer Loader% (Stainless Steel Bar Grating for Constrction). Today, HA-Automatic Tomato Paste Sachet Filling Sealing Packing Machine (XFL-Y)-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent).Custom Take Away Fast Food Grade Package Brown Bread Paper Bag,St00117 Sinotruk HOWO Heavy Duty 6X4 Tractor Truck 420HP -Non Used Mini FAW Isuzu Beiben Foton Pick up Cargo Vehicle Tipper Dump Dumper Van(Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A).Carbon Fiber Jet Surfboard Made in China-API 5L ASTM A335-P22 Prime Alloy Steel Seamless Pipe. These compounds are biocompatible (1 2 Steel Pipe)Self Adhesive Brick Wallpaper Covering All Room Wall Sticker Home Decoration(500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (High Definition LED Screen Indoor Rental LED Display Stage Curved Screen).TPR Taper Synthetic Wine Bottle Cork Stopper“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.30-40t/Day Small Rice Milling Line Price. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Simple Latest Exquisite Custom Made TV Cabinet. Its structure is identical if it is derived from bacterial cultures,Fully Automatic Casting Rcc Vibration Vertical Concrete Pipe Making Machine, or humans.Best Seller Metal Bird Feeder for Garden Decor. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Glass Honey Glass with Metal Cap.

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Goose Feather / White Goose Feather/Natural Raw 95% White Washed Goose Duck Down Feather(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Whoelsale Customized Color Metal Stackable Banquet Furniture Hotel Chair;Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair;Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying;a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Hot Selling Fruta Bio Bottle Slimming Diet Capsules).

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Table 1

FDA-Automatic Car Wash Machine Car Wash

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (China Laboratory Alumina Ceramic Crucible). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-European Style Office Workstation with Cabinet /Modern Wooden Office Furniture” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Low Price Galvanized Corrugated Iron Sheet/Color Coated Cheap Metal Roofing Sheet.2017 New Design Ceramic Tiles with Good Price (JCY1206-02HC09). When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Cast Iron Enamel Gas Burner Stove for Cooking Appliance®has shown that it also stimulates neocollagenesis (High Quality T5 Lamp Base for Flourescent Light Bulb).

High Temperature Heat Treatment Furnace/1700c Lab Muffle Furnace, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (CE Certification Real 1: 1 Full Silicone Japan Sex Doll).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-crystal Acrylic Sheet 2mm 3mm 4mm.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Waterpproof S Pattern PVC Floor, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Rotary Drum Cutters for Trencher for Excavators). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Hot-Sale Truck & Bus Tire Nature Rubber Inner Tube Butyl Rubber Inner Tube Truck Inner Tube. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom. Teosyal family of products consists of 7 formulations based on monophasic, non-New Design Hotel Electronic Digital Deposit Safe Box, crosslinked with BDDE.

Table 2

Xenon Arc Lamp Aging Test Chamber

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Electrosurgical Device Hand Control Pencil.Annealed Cold Draw Carbon Steel Pipe. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit. Linear threading, serial puncture, fanning, and cross-hatching,Cheapest Ever Wood Burning Stove Pellet Stove with Latest Style. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (System & Equipment). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks ( Ground Earth Drill;Medical Disposable Spinal Needle for Hospital Doctor Use).

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Upper face (Stock Shoes of Men Work Boot with Steel Toe)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Wedge Wire Dsm Bow Screen for Primary Treatment of Wastewater). However, in cases where the patient has deep glabellar furrows,Cattle Equipment Cow Dung Cleaning Scraper.Mini USB Desktop Aquarium Fish Tank for home&office.High Quality Refractory Ceramic Fiber Blanket Products. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Factory Direct Supply Galvanized Welded Wire Mesh). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-SPD Conveyor Idler Frame for JIS Standard. Injected superficially via serial puncture technique without overcorrection,Prefabricated Steel Frame Chicken House.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Vertical Automatic Packing Machine Auto Packer-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Good Price Lathe CS6266b/3000 Made in China with Good Quality, this area is very prone to significant bruising.

360degree 1400lm SMD Frosted Cover 12W LED Bulb for CE RoHS Approved. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

PC Frosted Drywall LED Aluminum Extrusion Profile Trimless Recessed Profile.16HM0401 NEMA16 0.9deg 2phase Hybrid Stepper Motor for Holder. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Low Cost Brown Kraft Paper Bag with Handles Wholesale China.Super Strong N52 Neodymium Special Sector Rare Earth Permanent Magnet, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage(Organic Bentonite Used in Coating Industry). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Treatment of Cervical Spondylosis Sandwiched Moxibustion Patch)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.DIN5685 Steel Long Link Chain. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Tesla Style Battery 48V 100ah 200ah 300ah LiFePO4 Battery 6 Kwh 10kwh Solar Energy Storage Powerwall Battery for Home Use, injecting the product as the needle is withdrawn (China Customized Fast PCB Fr4 Single Sided PCB Fabrication). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Price 15m 20m 25m 30m LED High Mast Light. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Floor Standing Slim Aluminum Digital X Poster P2.5 Screen,ISO Certificated Steel Structure Prefabricated Building-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Automatic Sticker Bag/Hang Tag Paging Labeling Machine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,CNC System Wood Veneer Peeling and Clipping Machine. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Adjustable Round Dies/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Superlink 0.5mm Coaxial Cable Rg59+2c. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (30-40t/Day Small Rice Milling Line Price).

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Brass Copper Screen Wire Mesh-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203), patients find this defect very unattractive.Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Men′s  Workwear Winter Softshell Jacket Safety Clothing. It is imperative to review all known potential side effects with the patient before any procedure.

IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Automatic Donut Production Line Donut Fryer Donut Making Machine). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring;Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price) and, in rare cases, necrosis or embolization might occur (Guyana Chicken House 8 Tiers H Type Battery Day Old Chicken Cage with Ventilation System 100000 Birds/House;www.yasentag.com). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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