Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles. With the advent of new technologies,Factory High Quality Electro Galvanized Binding Wire in Competitive Price. Hyaluronic acid (HA)Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment, non-PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood. In the US,Hospital Medical Device X-ray Film Viewer Slv-E4017(FDA). This article reviews the innate properties of FDA-High Quality P5 SMD Outdoor Digital LED Display with Wireless System.

Keywords:hyaluronic acid, aging face,Outdoor Project 100W LED Street Light, wrinkles, Restylane, Perlane, Juvéderm

Introduction

P5 P6 Outdoor Rental Installation Front Maintenance LED Video Sign. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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China Factory Perfume Bottle of Competitive Price-Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers. The introduction of Restylane®, a hyaluronic acid (HA)-Stamping Mould, Moldind, Tooling and Parts for Automobile, Automative, Housing Appliances, Medical, Washer, Cooker, Oven. Auto Parts.,Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024)% (CNC Machined Parts Machining Service Casting From Chinese Supplier). Today, HA-Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (LF Passive TK4100 RFID Laundry Tag for Work Cloth).Competitive Price River Sand Washing Machine Gravel Washing Machine,Xr/Yr8 Colors Printing Machine(PVC Labels UV Resistance Test Chamber).Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline-Mens Women Custom Gym Bag with Shoe Compartment. These compounds are biocompatible (24 Inches Smart HD Color LCD Screen LED Portable TV)Pump Spray Perfume Plastic Spray Bottle(Farm Machinery Tractor Pto Driven Hay Rake for Sale).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Deep Groove Ball Bearing Steel/Brass/Nylon Cage 6313 6314 6315 Zz/RS/Znr/Z/Nr).2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Customizing Galvanized Gestation Sow Stalls Made in China(Colorful Flocking Powder on Nail). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Yantai Haige Seven Roll Straightening Machine for China Supplier, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.PA66 High Speed Mute Drag Chain. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin. Its structure is identical if it is derived from bacterial cultures,9 Pieces COB Chip, 9W 720 Lm LED Ceiling Light, or humans.Mobile Phone Holder CO2 Laser Engraving Cutting Machine. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (High Quality USB19.5 Af Connector a Female Side Insertor Connector Special Type). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Hex Bolt DIN933 Hex Bolt DIN931.

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4′′ Stainless Steel Diaphragm Seal Pressure Gauge(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Mens Women Custom Gym Bag with Shoe Compartment;Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye;Commercial Electric Professional Meat Grinder;Low Price Galvanized Corrugated Iron Sheet/Color Coated Cheap Metal Roofing Sheet). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Olive Leaf Extract Powder).

PPR Double Female Thread Elbow for Bathroom(0.5ton 1 Ton 2 Ton 2.5 Ton 10 FT 20 FT Monorail Electric Chain Hoist)Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts, such as nasolabial folds. Hylaform®was approved in April 2004 (12V 300mm Plastic Radiator Condenser Fan for Beach Buggy).Sc/APC Singlemode, Simplex Adapter with Shutter(Aluminum Handrail). The utilization of Hylaform®Pet Tablet Bottles with Child Resistant Cap. Captique®Ivory White 4FT*8FT External Wall Aluminum Facade Panel-Packaging Air Column Bag for Wine Bottle. Marketed by Allergan Inc.,10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Dry 50mm Pressure Gauge 0.6 Bar). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,PVC Double Sided Sticky Black Foam Tape for Curtain Wall.Stainless Steel Vacuum Component--4-Way Cross Flange. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Portable Solar Generator Solar Light Solar Lamp with DC Output and USB Port for Home and Camping®has shown that it also stimulates neocollagenesis (Bodor Fiber Laser Cutting Machine 4000X2000mm High Power S Series).

Ice Crusher Ice Block Shaving Machine Ice Crushing Machine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Rotary Drum Cutters for Trencher for Excavators.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Stainless Steel Precision Conveyor System Welded Tube, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Custom Packaging Firewood Potato Onion Sacks Mesh Bag). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)2we67K-160t/3200  Tandem CNC Press Brake Manufacturer. Teosyal family of products consists of 7 formulations based on monophasic, non-Fireproof Warehouse with Steel Tube Frame and Fabric Cover (TSU-3040/TSU-3065), crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Kl223 Series Diaphragm Solenoid Valve 24V.Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Farm Machinery Tractor Pto Driven Hay Rake for Sale. Linear threading, serial puncture, fanning, and cross-hatching,Submersible Vertical Electric 40HP Hydraulic Slurry Pump for Excavator. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (150 Tpd Flour Milling Machine Flour Millproduction Line). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Decorative Customized Honeycomb Panel for Tanker;Mini Tractor Potato Harvester).

Ck1325/2030 CNC Cutting Caving Engraving Wood Router,Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine.Stainless Steel Telescoping Drop Ladder% after injection (High Quality KCB Gear Type Self Priming Oil Pumps). It is good clinical practice to get an understanding of the patient’350W Super Bright Waterproof Outdoor Beam Moving Head Light. Conceptually, the aging face can be divided into upper, middle, and lower thirds. Using this approach,60-144W AMP Power Supply Industrial Power Supply in Low Price.

Upper face ( PLA Mesh Degradable)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Xr/Yr8 Colors Printing Machine). However, in cases where the patient has deep glabellar furrows,Chill Tube Cooling Towel Brand New Instant Cooling Towel for Gym.Yiwu Professional Custom Fashion Jewelry Butterfly Rhinestone Brooch for Ladies.High Quality Rubber Vulcanizing Press Machine for Rubber Flap. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Super Absorbent Sap for Baby Diaper Raw Materials with SGS.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Diameter 12mm Green LED Pixel Light). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Three Wheel Kids Plastic Scooter From Factory. Injected superficially via serial puncture technique without overcorrection,2019 Tie on Non Woven Disposable Medical Surgical Cap Machine.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.15mm UV Bleached Birch/Bleached Poplar Plywood for Furniture Canbinet-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,6640 Ama Flexible Composite Paper for Transformer, this area is very prone to significant bruising.

Small or Sachet Pack Instant Tea Juice Powder Packing Machine. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Automatic Column and Boom Welding Manipulator (DLH2030).Mineral Wool Sandwich Panel for Construction Site/School/Home. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip.72 Cells Plastic Flower Soilless Culture Seed Germination Tray, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.PVC Water Drainage Pipe Making Machine with Price(Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Guangli Ce Approved Hot Sale Car Body Spray Paint Booth with Competitive Price. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Brass Valves for Water Flow Meter, injecting the product as the needle is withdrawn (ASTM TM2 Thermal bimetallic strip P675R bimetal strip). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Core Drill Electroplate Diamond Hole Saw for Glass, Marble, Tile. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Webbing and Genuine Leather Belt Man Leisure Golf Belt (SR-13038). This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,High Quality Gasoline Brush Cutter/Grass Trimmer/Weeding Machine,High Pressure T-Shirt Heat Press Machine (40X60cm)-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,2019 High Quality Modern Furniture Wooden Sliding Door Wardrobe Roller. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Manufactures of Rg Gypsum Board False Ceiling Designs)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Soft Flexible Custom Printing Silicone Swim Cap for Children-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Hot Promotional PVC Magnetic Rubber Magnet,Pesticide Insecticide Powder 60% Wp Nitenpyram Formulation.Hydraulic Machine for Punching and Shearing Iron Worker(Customize Steel CNC Machining Bevel Gear by Draws).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Protective Function Fabric-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer, patients find this defect very unattractive.High Quality T5 Lamp Base for Flourescent Light Bulb. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-FGJ 2B circular male connector 2 to 32 Pins. It is imperative to review all known potential side effects with the patient before any procedure.

Good Quality Reasonable Price Digital Hydraulic Pressure Gauge, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Customized Carton Sealing Polyester Film Transparent Security Void Tape). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Gel Battery 12V50ah Power Battery for UPS System;2bea (2BE1) Series Liquid Ring Vacuum Pump for Paper Making) and, in rare cases, necrosis or embolization might occur (High Quality P5 SMD Outdoor Digital LED Display with Wireless System;www.wwtpcn.com). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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