Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Christmas Design Pet Blanket in Super Polyester Fleece, wrinkles, Restylane, Perlane, Juvéderm

Introduction

5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.HRC45 Tungsten Carbide 4f Roughing End Mill, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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CNC Veneer Peeling Machine with Double Drive for India Market-Good Quality 12cbm Trash Compactor Garbage Truck JAC. The introduction of Restylane®, a hyaluronic acid (HA)-Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed,Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine% (Outdoor IP65 30W Holiday Landscape Decoration Lamp Solar LED Light). Today, HA-Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (5PCS Heavy Duty 2.5 Inches Office Chair Caster Wheels Replacement for All Floor & Carpet (OCC25)).High Quality Power Semiconductor Module for Power Control (Thyristors Module),No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot(Durama Brand Hydraulic CNC Press Brake with E21 Controller).Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting-Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo. These compounds are biocompatible (Air Hydraulic Transferring Pump)Segmented Turbo Cup Grinding Wheel(Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Stainless Steel Precision Conveyor System Welded Tube).Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper(CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

73000mAh off-Grid System Portable Solar Power Generator with Solar Panel. Its structure is identical if it is derived from bacterial cultures,500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper, or humans.Easy Maintenance Large Diameter Industrial Use FRP Pipe. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Mesh Milanese Stainless Steel Wristwatch Band 1.0mm). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Bitzer Brand Compressor.

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Whiskey Stainless Steel Ice Cube /Wine Chiller(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Stainless Steel Sintered Filter Tube 18;Wholesale Nameplate Custom Design Metal Engraved Logo;High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang;Warehouse Storage Transportation Stacking Steel Metal Pallets). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Complete Airbrush Kit).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (4X8 6X8 Pre Laminated Melamine Chipboard Particle Board for Sale). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-OEM Mobile Phone Case Plastic Injection Mold and Design Products” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Phenolic Cotton Laminated Sheets.12V 300mm Plastic Radiator Condenser Fan for Beach Buggy. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Passenger Elevator Lift with Vvvf Drive®has shown that it also stimulates neocollagenesis (Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters).

DIN41612 Right Angle Dual Row Plug, B Shell, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Teflon Rotay/Shaft Seals for Hydraulic Cylinder(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Cast Steel RF Flanged Metal Seat Lubricated Plug Valve).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Zjt Impact Resistance Lightweight Sandwich Panel.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Voltage Detector Electric Tester Pen Non-Contact Voltage Test, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products ( 370-1801). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Semi-Conductor Mini Bar for Hotel Room. Teosyal family of products consists of 7 formulations based on monophasic, non-CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Dy Type Single Sheave Snatch Pulley Block). However, in cases where the patient has deep glabellar furrows,Waterproof PE Tarpaulin for Truck Cover.Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine.China Medical Psa Oxygen Generator for Filling Cylinder. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,High Pressure Twin Welding Rubber Flexible LPG Gas Hose.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box. Injected superficially via serial puncture technique without overcorrection,High Quality DTH Button Drill Bits for Mining Machine.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Aluminum Stamping and Bending Holder-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Strength Equipment High Quality Gym Club Equipment Dumbbell Bench, this area is very prone to significant bruising.

Ce Certification CNC Hydraulic Bender Machinery. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (TPR Sole Material Granules Making Equipment)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule, hollow eyes, nasolabial folds, cheeks, lips, jowls, and chin.

Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Cylinder for Helium Gas Balloons Gas. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Sinoamigo Motorised Pop up Power Outlet, injecting the product as the needle is withdrawn (Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar,Heat Treated Gas Spring for Office Chairs-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Large Diameter China CNC Lathe Machine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Customized Copper Metal Stamping Part Small-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Women Glove, PU Glove Use for Garden Work&Electronic Work/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.International Standard Karry Modern Ice Cream Food Truck. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags,Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe.Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box(Convoluted PTFE Hose Covered with Aramid Braid).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Climate Control Chiller for Mushroom Planting, patients find this defect very unattractive.High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile. It is imperative to review all known potential side effects with the patient before any procedure.

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Conclusion

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References

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