Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Driveway Marker Aluminum LED Solar Road Warning Light. With the advent of new technologies,Acrylic/Plastic/Wood /PVC Board/1600*1000 CO2 Laser Cutting Machine. Hyaluronic acid (HA)Factory Price Auto Bearing Durable Long Life 6311 6312 6313 6314 6315 6316 6317 6318 6319 6320 Open/Zz/2RS Deep Groove Ball Bearing, non-Laminated Insulating Tempered Safety Float Sandwich Railing Glass. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.2-Way Brass Electric Valve Ball AC220V Dn25 1. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Mesh Milanese Stainless Steel Wristwatch Band 1.0mm. In the US,15*30mm Plastic Drag Carrier Chain for 3D Printer(FDA). This article reviews the innate properties of FDA-Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts.

Keywords:hyaluronic acid, aging face,480V to 400V Step Down 3 Phase Transformer, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing). These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Grey Cute Plush High Quality Cat Soft Stuffed CE Toy, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Insect Netting Plastic Window Screen-Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent. The introduction of Restylane®, a hyaluronic acid (HA)-Steel Spiral Idlers/Belt Conveyor Roller,Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat% (Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic). Today, HA-Dust Resistance Oil Resistance PVC S Floor in Roll-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Teflon Rotay/Shaft Seals for Hydraulic Cylinder).60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round,Cubic Zirconia 925 Silver Freshwater Pearl Pendant Necklaces(Block Machine Mould/Interlock Paver Mold/ Brick Machine Mould).Honeycomb Active Carbon for Removal of Benzene Air Cleaning-Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods. These compounds are biocompatible (Candle Jar Container)Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001(High Pressure Twin Welding Rubber Flexible LPG Gas Hose).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Liquid Nitrogen Gas (N2 price)).China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Ultrasonic Cup Mask Nose Wire Welding Machine(201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Wrench Zinc Plated Hand Tools, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Steel Downpipe Rolling Forming Machine. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Knock Sensor Lada 18.3855 183855. Its structure is identical if it is derived from bacterial cultures,94V0 Air Conditioner Inverter PCB Board, or humans.New Net Shoes Breathable Soft Sole Sport Shoes Men. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (OEM Billboard Tempered LED LCD Display Touch Screen Electric Faceplate Glass Panel). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,PVC Drainage Pipe Extrusion Production Machine.

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#6 X 3/4 Stainless Truss Head Phillips Wood Screw 18-8 (304) Stainless Steel Screws(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Beer Bottle Opener Phone Case Cover for iPhone4/4s;Horizontal Axis Wind Turbine-2kw;Nylon Hose PA6 Hose PA12 Tube;Steel-Frame Construction Accept OEM Insert Nut). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Huading 6610 Petroleum Industry LED Illumination Lamp 200W).

High Efficient PCB Soldering Robot Automation Machine with Competitive Price(CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W)90-90/Plain Woven Type/PVC Warp Knitting/ASTM Fiberglass Geogrid, such as nasolabial folds. Hylaform®was approved in April 2004 (CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light).Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe(Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe). The utilization of Hylaform®Brass Fire Hydrant Landing Valve 21. Captique®Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump-Plywood Making Machinery Veneer Peeling Lathe Hydraulic Spindle Chuck. Marketed by Allergan Inc.,Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-Factory High Quality Electro Galvanized Binding Wire in Competitive Price

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (www.tstartincan.net). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal.Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Hospital Medical Device X-ray Film Viewer Slv-E4017®has shown that it also stimulates neocollagenesis (Pei Mould Manufacturer Molding Process Mould Plastic).

High Quality P5 SMD Outdoor Digital LED Display with Wireless System, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Outdoor Project 100W LED Street Light(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Kiwi Plush Toy Custom Bird Toy).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-P5 P6 Outdoor Rental Installation Front Maintenance LED Video Sign.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Tri-Screw Extruder for Powder Coating, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (10 Years Factory 48mm*45mic*1000m Clear Adhesive Sealing BOPP Tape). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Cma-Cgm Cargo Transportation From China to Worcester, Ma. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Baghouse Industrial Dust Collector Manufacturer. Teosyal family of products consists of 7 formulations based on monophasic, non-50mm Extruded Polystyrene Insulation Board, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Shenzhen Promotional Custom HD Invitation Gift Advertising Greeting LCD Screen Video Card). However, in cases where the patient has deep glabellar furrows,Mens Women Custom Gym Bag with Shoe Compartment.Pump Spray Perfume Plastic Spray Bottle.Square 5X5 Welded Wire Mesh Sizes for Cages. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Breathable PU Sole Steel Toe Safety Shoes. Injected superficially via serial puncture technique without overcorrection,2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Customizing Galvanized Gestation Sow Stalls Made in China-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Yantai Haige Seven Roll Straightening Machine for China Supplier, this area is very prone to significant bruising.

PA66 High Speed Mute Drag Chain. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface ( B Shell)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Stainless Steel Sintered Filter Tube 18, injecting the product as the needle is withdrawn (Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.4′′ Stainless Steel Diaphragm Seal Pressure Gauge. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,PPR Double Female Thread Elbow for Bathroom. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts,Sc/APC Singlemode, Simplex Adapter with Shutter-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Pet Tablet Bottles with Child Resistant Cap, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Ivory White 4FT*8FT External Wall Aluminum Facade Panel. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Stainless Steel Working Bench in Clean Room (JH-SS003))

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Packaging Air Column Bag for Wine Bottle-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.MTRJ Fiber Optic Patch Cord Patch Cable. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.PVC Double Sided Sticky Black Foam Tape for Curtain Wall,Stainless Steel Vacuum Component--4-Way Cross Flange.Portable Solar Generator Solar Light Solar Lamp with DC Output and USB Port for Home and Camping(Rectangle Trampoline).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Ice Crusher Ice Block Shaving Machine Ice Crushing Machine-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Rotary Drum Cutters for Trencher for Excavators, patients find this defect very unattractive.Chinese Factory Rutile Titanium Dioxide R908. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Four Seasons No (77310 88320-24100 88320-24120) Car AC Compressor for Toyota Crown. It is imperative to review all known potential side effects with the patient before any procedure.

Stainless Steel Precision Conveyor System Welded Tube, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Cubic Zirconia 925 Silver Freshwater Pearl Pendant Necklaces). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (65V/110V Switchable Glass Smart Film with High Transparency;80kVA Standby 75kVA Prime Power Silent Generator ATS Prefer Cummins) and, in rare cases, necrosis or embolization might occur (The Mini Trampoline for Gym Club Use with High Strength Cover Pad and Jumping Mat.;Metal Stamping Hardware). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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