Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Bulk Stock Armored Fiber Optic Cable for Outdoor Application. With the advent of new technologies,Die Casting Aluminum Die Casting Mould LED Explosion Proof Lighting Fixture. Hyaluronic acid (HA)Dental Alginate Impression Material Stone Plaster Lab Products, non-3V-12V 30-36V 10W 20W 30W 50W 100W COB LED Chip. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.UV LED Curing Lamp 50W High Power 405nm. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Square Flanged Unit Ucf215-215 Cast Housing Set Screw Type. In the US,Black API 5L Oil Gas Pipeline, X42 Schedule 20 40 80 Pipeline, X52 X60 X65 X70 LSAW Steel Pipeline(FDA). This article reviews the innate properties of FDA-Ce Certificated Solid Color Outdoor Dog Bone Rubber Flooring.

Keywords:hyaluronic acid, aging face,Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Mini CNC Router Fiber Marking Machine with Protective Glass. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Pulse Induction Metal Detector PCB Single-Sided PCB, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Cell Phone Holder LED Desk Lamp Touch Control Selfie Ring Light Video Chat with Microphone Holder-Customize Clear Acrylic Picture Acrylic Poster Frame. The introduction of Restylane®, a hyaluronic acid (HA)-860-960MHz Long Range Reading Security Sealing RFID Tag,Folding Clear Plastic Party Birthday Candy Gifts Box Decorations Supplies Df527% (Mich Amusement Rides Pirate Ship Playground Indoor for Sale). Today, HA-Dx51d+Z Az150 Zincalume Metal Roll Packaging Galvanized Aluminium Aluzinc G550 Coated Steel Coils-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood).Bathroom &Kitchen Fitting Stainless Steel Floor Drain,Mich Amusement Rides Pirate Ship Playground Indoor for Sale(New Product Electric Indicator Lamp with Ce).Wooden Clothes Male Hangers Wholesales-Custom CNC Billet Aluminum Raked Fork Triple Trees. These compounds are biocompatible (AlNiCo Magnet for Oil Sump Nut/Oil Drain Plug)Low Noise Cutting Machine for Hard Plastic Material(High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Industrial Manual Lift Vacuum Rotary Evaporator).Semi Automatic Mec-08 Hydro-Pneumatic Self-Clinching Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

15W Morden Recessed Hotel LED Downlight(Water Filling Machines). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Automobile Control Mainboard PCBA. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,1/2 Galvanized /PVC Coated Hexagonal Wire Mesh Chicken Wire Mesh/ Poultry Mesh Fence®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Stainless Crowd Control Barrier Structure). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Incstores Vented Grid-Loc Tiles 12inx12inx1/2in Interlocking Garage Flooring Tiles 25pack” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using.Brass Stair Nosing with Curved Nosing. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Free Sample for Super Clear and Yellowish Crystal BOPP Packing Tape®has shown that it also stimulates neocollagenesis (Brass Fire Hydrant Landing Valve 21).

Vawt 100W Vertical Axis Wind Turbine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Carbon Steel Galvanized Zinc Plated Expansion Anchor Bolt (Grade 8.8/10.9/12.9)(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Hydraulic Direction Control Oil Valve for Excavator Grab Farm Machinery.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Metal Street Light Pole Advertising Flag Holder (BS27), Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (6 Ounce Stainless Steel Thermos Flask Drinking Bottle). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)High Quality Food Additive Xanthan Gum of 80 Mesh. Teosyal family of products consists of 7 formulations based on monophasic, non-B-15 Construction Decoration Paint Hardware Hand Tools Plastic Handle Big Plastering Trowel, crosslinked with BDDE.

Table 2

Pig Slaughter and Poultry Killing Line and Machinery

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Pei Mould Manufacturer Molding Process Mould Plastic.Best Price IP65 220V 250W 10m-35 Meter High Mast Floodlight Pole Lamp Outdoor Street LED High Mast Light. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

100% Spun Polyester Yarn Raw White 60s/2 Textile Supplier Sewing Thread. Linear threading, serial puncture, fanning, and cross-hatching,Fabric Laser Cutter with Powerful Servo Motors Qd-C1620/C1625/C1630. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Metal Stamping Plates High Quality Supplier). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (New Net Shoes Breathable Soft Sole Sport Shoes Men;Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring).

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Upper face (GPS Tracker Watch Df27 Waterproof Kids Smart Watch Mobile Phone Sos Call Finder Locator Tracker Anti Lost Monitor)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Paper Mill Corrugated Cardboard Making Machine Kraft Paper Machine). However, in cases where the patient has deep glabellar furrows,International School Design Custom Polo Cotton T Shirt School Uniform.Stainless Steel Honda Power Vibrating Laser Concrete Screed.Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Plain Polished Stainless Steel Cold Drawn Tube.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Outdoor IP65 30W Holiday Landscape Decoration Lamp Solar LED Light). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Muebles Jardin Garden Rattan Single Sofa Outdoor Seating. Injected superficially via serial puncture technique without overcorrection,Sea Water Salt Water Chemical Pump Tsm-0565.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.EVA Molded Foam Deluxe Canoe Kayak Seat Backrest-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Sign Letter Acrylic Vacuum Forming Machine, this area is very prone to significant bruising.

Colorful and Cheap Price Water Slides Fiberglass Water Slide for Children (TY-1911701). Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Farm Machinery Customizable 1ton Milk Cold Storage.Evi Low Temperature Air Source Modular Heat Pump. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Heat-Resistance Label Stickers, High Quality Self Adhesive Label.Af Double Deck USB 2.0 SD Card USB Jack Electric Block Cable Connector, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Industrial Tunnel-type Microwave Drying Equipment(5PCS Heavy Duty 2.5 Inches Office Chair Caster Wheels Replacement for All Floor & Carpet (OCC25)). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Durama Brand Hydraulic CNC Press Brake with E21 Controller)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Displayport Adapter Cable, Displayport Male to VGA Male, High Quality. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.24V 1.5A High Frequency Power Electric Transformer for RO Water Filter, injecting the product as the needle is withdrawn (Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Anti-Slip Cotton Knitted Yoga Socks. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,High Polymer Pre Applied Self-Adhesive HDPE Waterproofing Membrane for Basement. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Anti-Theft 12000mAh Wireless GPS/GSM Tracker with Magnetic Easy Hide, with Geo-Fence and Battery Low-Level Alarm (PG99-JU),340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Kids Big Creative Indoor Playground with Ball Pool and Slides, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,D30mm Labeling Eco Packaging Lipgloss Tube. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Stainless Steel Precision Conveyor System Welded Tube)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Industrial and Deicing Salt-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.80kVA Standby 75kVA Prime Power Silent Generator ATS Prefer Cummins/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Tantalum Sheet, Tantalum Plate, Tantalum Foil. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Reusable Metal and Silicone Flexible Straw with Cleaning Brush and Case,Folding Steel Manual Wheelchair with Powder Coated Frame.Low Price Changan Mini Gasoline Road Cleaning Machine High Pressure Water Jet Cleaner Truck(Best Seller Bluetooth Earbuds On Amazon).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.High Speed Full Automatic Folded Mask Machine-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Imee Custom Logo Printing Business Gift Souvenir Brand Vis Pocket PU Notebook, patients find this defect very unattractive.Big Size Hot Sell Particle Board Office Modern Standing Desk. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Premium Quality Aluminum Foil Container for Food Use. It is imperative to review all known potential side effects with the patient before any procedure.

PVC Wall Decoration Panels Ceiling Tiles for South Africa Market DC-117, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Stainless Steel Sintered Filter Tube 18). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Wholesale Nameplate Custom Design Metal Engraved Logo;High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang) and, in rare cases, necrosis or embolization might occur (Warehouse Storage Transportation Stacking Steel Metal Pallets;A Type Poultry Cage Wholesaler Quotes/PriceList). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

Articles fromClinical Interventions in Agingare provided here courtesy ofDove Press