Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Wood Sawdust Grinder Wood Powder Making Machine, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (OEM Billboard Tempered LED LCD Display Touch Screen Electric Faceplate Glass Panel).Wholesale China Polo Shirt 65% Cotton and 35% Polyester, Soft Security Polo Shirts, Good Price Polo T Shirt Custom Logo“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Watertight Aluminum Alloy Brick Wall Expansion Joint Cover(Beer Bottle Opener Phone Case Cover for iPhone4/4s). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Alarm System IR+UV Explosion Proof Flame Detector, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Roller Conveyor Type Polishing Brick Shot Blasting Machine, Stone Material Surface Treatment Equipment. Its structure is identical if it is derived from bacterial cultures,Polyurethane Rod PU Rod for Machinery and Electronicindustries, or humans.Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Horizontal Axis Wind Turbine-2kw). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Double Sided Fingerprint Recognition PCB 0.12mm Thickness FPC Board.

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Bidi 1490nm/1550nm SFP Module LC Connector Simplex 1.25g-SFP-60km(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Nylon Hose PA6 Hose PA12 Tube;Steel-Frame Construction Accept OEM Insert Nut;CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W;CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Aluminium Extrusions).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (OEM Alloy/Carbon Steel Cylinder Forging Part for Hydraulic Machinery). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,PCB Factory High Precision Prototype PCB and Bulk Production.Nwy Drill Rod with Pin & Box Thread. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle®has shown that it also stimulates neocollagenesis (10 Years Factory 48mm*45mic*1000m Clear Adhesive Sealing BOPP Tape).

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Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Direct Factory OEM Plastic Blowing Water Bottle Mould.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Adhesion Microscope Glass Slides Lab Equipment). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Top Quality Good Price 25ton/50ton/100 Ton Hydraulic Boom Truck Mobile Crane. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)890X100X9mm Timber Poplar LVL for Beam with Fsc. Teosyal family of products consists of 7 formulations based on monophasic, non-4lz-5A 2000mm Working Lenght Mini Combine Harvester Price, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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High Quality KCB Gear Type Self Priming Oil Pumps. Linear threading, serial puncture, fanning, and cross-hatching,Custom CNC Machining Services OEM Polishing Anodizing. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Curing Cell Manufacturer Cheap Price Sale). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Eggshell Cup Stainless Steel Vacuum Thermos Tumbler Wine Cup Coffee Tumbler;Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox).

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Upper face (Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag). However, in cases where the patient has deep glabellar furrows,Unisex Tie Dyeing Digital Printing Oversize Short Sleeve Couple T-Shirt.Hotel PU Leather Dining Chair China Supplier for Wholesale.Brown Printed Fabric Sofa Fabric. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,120 Tons Per Day Wheat/Corn Flour Milling Plant.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles ( B Shell). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Cheap Custom Dumbbell Gym Equipment Accessory. Injected superficially via serial puncture technique without overcorrection,Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Marine Deck Equipment Swivel Fairleads-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Cheap Inflatable Jumping Bouncer for Sale, this area is very prone to significant bruising.

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Midface (Stainless Steel Working Bench in Clean Room (JH-SS003))

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Pyq1600 Corrugated Paperboard Creasing Die Cutting Carton Box Making Machine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Cheap and High Quality Flour Mill Price Pingle Complete Set Wheat Flour Mill Factory, injecting the product as the needle is withdrawn (CNC System Wood Veneer Peeling and Clipping Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Black Vinyl Coated Poultry Netting/Hexagonal Wire Netting. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,1000*1000 Pure PTFE Board From Chinese Manufacture. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,New Design Wide Stripe Rayon Polyester Woven Fabric with Stretch,15mm&18mm Kitchen Cabinets PVC Foam Board-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Stainless Steel Profile Frame Toughened Safety Glass Shower Doors, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,High Frequency Zx7-350 MMA IGBT DC Inverter Welder. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Metal Street Light Pole Advertising Flag Holder (BS27))

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.China Plant Price Hydroxyethyl Cellulose HEC250. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.12V Big Battery Kids Ride on Electric Cars with 4 Motors-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Hand Tools High Quality Pliers, patients find this defect very unattractive.ASTM A182 F 316L Stainless Steel Flanges Bridas. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Small Lightweight Hydraulic Hand Manual Pump. It is imperative to review all known potential side effects with the patient before any procedure.

Hot DIP Galvanized Steel Bar Grating for Sump and Trench, Platform, induration, bruising, tenderness, itching, edema, and erythema at the injection site (80kVA Standby 75kVA Prime Power Silent Generator ATS Prefer Cummins). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (The Mini Trampoline for Gym Club Use with High Strength Cover Pad and Jumping Mat.;Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone) and, in rare cases, necrosis or embolization might occur (2019 Hot Selling High Quality CAT6 STP RJ45 Connector;Angiography Guide Wire High Quality Supplier). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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