Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

LF Passive TK4100 RFID Laundry Tag for Work Cloth. With the advent of new technologies,Automatic Car Wash Machine Car Wash. Hyaluronic acid (HA)Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire, non-European Style Office Workstation with Cabinet /Modern Wooden Office Furniture. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Low Price Galvanized Corrugated Iron Sheet/Color Coated Cheap Metal Roofing Sheet. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,2017 New Design Ceramic Tiles with Good Price (JCY1206-02HC09). In the US,Cast Iron Enamel Gas Burner Stove for Cooking Appliance(FDA). This article reviews the innate properties of FDA-High Temperature Heat Treatment Furnace/1700c Lab Muffle Furnace.

Keywords:hyaluronic acid, aging face,Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table, wrinkles, Restylane, Perlane, Juvéderm

Introduction

crystal Acrylic Sheet 2mm 3mm 4mm. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Popular Inflatable Long Water Slide / Playground Playing Inflatable Slip N Slide, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Annealed Cold Draw Carbon Steel Pipe-2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit. The introduction of Restylane®, a hyaluronic acid (HA)-Cheapest Ever Wood Burning Stove Pellet Stove with Latest Style,Stainless Steel Working Bench in Clean Room (JH-SS003)% (300X600 Rough Surface Full Body Porcelain Floor Wall Tiles). Today, HA-Customized Safety Food Grade Rubber Gasket Sealing Ring (SWCPU-R-OR043)-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Organic Pure Nature Beeswax).Medical PVC Nelaton Catheter for Female and Male,CNC Paperboard Spacers Milling and Processing Machine(Fireproof Warehouse with Steel Tube Frame and Fabric Cover (TSU-3040/TSU-3065)).650c Bike Wheel Sets/40mm Rim Depth Wheel Sets/Double Wall Rim /Sy-Ws-45m-Cattle Equipment Cow Dung Cleaning Scraper. These compounds are biocompatible (OEM/ODM Factory Quick Charge Usb Charger - Automatic Charging 12V 12A 7 Stage Battery Charger - Ligao)Mini USB Desktop Aquarium Fish Tank for home&office(Plywood Making Machinery Veneer Peeling Lathe Hydraulic Spindle Chuck).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (50mm Extruded Polystyrene Insulation Board).Prefabricated Steel Frame Chicken House“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.360degree 1400lm SMD Frosted Cover 12W LED Bulb for CE RoHS Approved. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh(PVC Wall Decoration Panels Ceiling Tiles for South Africa Market DC-117)Floor Standing Slim Aluminum Digital X Poster P2.5 Screen, such as nasolabial folds. Hylaform®was approved in April 2004 (Wholesales Price Big Capacity Double Glass Door Showcase Beverage Cooler).ISO Certificated Steel Structure Prefabricated Building(Factory Manufacturing Volt Gauge for Vehicles and Ships). The utilization of Hylaform®Automatic Sticker Bag/Hang Tag Paging Labeling Machine. Captique®CNC System Wood Veneer Peeling and Clipping Machine-Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale. Marketed by Allergan Inc.,Adjustable Round Dies(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Double Head Duplex Nail Polished Drywall Screw). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Ms Carbon Steel Chequered S275jr Ss400 A36 Checkered Steel Plate Price.3 Axle Lowbed Truck Trailers for Sale. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs®has shown that it also stimulates neocollagenesis (6 Meters Length Light Duty Livestock Lorry Truck).

Brass Copper Screen Wire Mesh, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Advertising Auto Car Headrest Cover(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Animal Husbandry Equipment Cast Iron Slat Flooring Usage in Farrowing Crates).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203).3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Commercial Electric Professional Meat Grinder. Linear threading, serial puncture, fanning, and cross-hatching,Aluminum Corner Edge Trim, Strip Profile. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (BS1873 High Temperature Cast Steel A216 Wcb Body OS&Y Rising Stem Plug Disc Integral Seat Overlay Stellie 13cr Disc Flanged or Butt Welding Globe Valve). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Low Price Changan Mini Gasoline Road Cleaning Machine High Pressure Water Jet Cleaner Truck;Size 00 Wholesale Bulk Empty Hard Gelatin Capsules).

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Upper face (Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Light Oil Burner Suitable for Various Kinds of Burners). However, in cases where the patient has deep glabellar furrows,High Quality Plastic Injection Edible Oil Cap Mould (YS747).150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load.Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Wholesale Hot Sales Cbb65A-1 Capacitor.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Wholesale Hot Sales Cbb65A-1 Capacitor). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe. Injected superficially via serial puncture technique without overcorrection,260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Drip Irrigation System Fittings 20mm Plastic Mini Lock Offtake Valve-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,High-End Ceramic Tile Laser Cutting Machine 80W/100W, this area is very prone to significant bruising.

High Quality Clear Tube Jail E-CIGS for Inmates and Prisons. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

China Manufacturer Observation Small Home Elevator.RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.2019 New Fashion Lace-up Running Sport Casual Shoe.Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service(Cheap Custom Dumbbell Gym Equipment Accessory). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Diamond Grinding Wheel Turbo Segment Aluminium Cup Wheels)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.12V-24V Universal Garage Door Opener RF Receiver Switch Yet402PC. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Manufacturer Outdoor Decorative Arm Galvanized Steel LED Street Light Pole, injecting the product as the needle is withdrawn (Self Adhesive Brick Wallpaper Covering All Room Wall Sticker Home Decoration). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Slim SMD Garden Spotlight LED Floodlight with White Housing. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,CE Certified Energy Recovery Unit, Counter-Flow Heat Exchanger (XHBQ-TP). This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,A234 Wpb ASME B16.9 Black Butt Welding Elbow 45 Deg,Customized Exhaust Pipe Insulation with High Temperature Resistance-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Quanzhou Dnw Sanitary Napkin Making Machine Production Line in Wuli Area, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Eggshell Cup Stainless Steel Vacuum Thermos Tumbler Wine Cup Coffee Tumbler. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Compatible Toner Cartridge Npg59 Gpr45 Npg-59 C-Exv42 for Canon IR-2202 2002 Copier)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.B7tc Spark Plug Motorcycle Accessory Motorcycle Spark Plug-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Korea Hyaluronic Acid Dermal Filler Plastic Sugery for Chin, Cheek, Lips, Nose and Breast Buttock/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Polished Super Black Porcelain Floor Tile. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Treatment of Cervical Spondylosis Sandwiched Moxibustion Patch,5.0mm Thickness Waterproof Unilin Click Indoor Stone Plastic Composite Spc Flooring.Tungsten Carbide Material Punching Mold Part for Stamping and Injector(EPS High Quality Steel Structure Prefabricated Waterproof Wall/Proof Panel).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.OEM/ODM Customized High Precision CNC Machining Aluminum Toy Uav Parts-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic, patients find this defect very unattractive.Tungsten Carbide Drill Bushing/Sleeve/Bush. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Aluminum Telescopic Flag Pole. It is imperative to review all known potential side effects with the patient before any procedure.

2019 New Procuct Naural Gas Leak Alarm with Ce ISO, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Ce Certified High Power Fibre Laser Cutting Machine for Metal;2017 New Design Ceramic Tiles with Good Price (JCY1206-02HC09)) and, in rare cases, necrosis or embolization might occur (Mars Solar Mini Portable Home 12V DC Solar Lighting System 500W UPS Portable Home Lighting Solar for Indoor and Outdoor Camping Kit;500kg Capacity Oil Drum Trolley). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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