Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

7.4V, 2600mAh Lithium Polymer Battery Pack for Heated Glove, Heated Shoes, Heated Insole, Heated Products (EH2600). With the advent of new technologies,Galss Fiber Reinforced Gypsum Cornice. Hyaluronic acid (HA)CO2 Jet Machine DMX Adjustable 0-180 Degree DJ Party Club Stage Special Effect Equipment, non-Cheap Price Tws Earbuds with Battery Charging Case Earphone OEM Excellent Quality for Sports True Wireless Custom Headset Akz-W4. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Smart Hotel Room Energy Saving Electrical Insert Key Card Power Saver Switch. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,High Frequency Facial Machine for Skin Deep Cleaning Machine. In the US,New 2.7inch 1080P Car DVR Recorder with Loop Recording, G-Sensor(FDA). This article reviews the innate properties of FDA-Bodor Fiber Laser Cutting Machine 4000X2000mm High Power S Series.

Keywords:hyaluronic acid, aging face,Disposable Skin Stitch Stapler and Staple Remover, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Alkaline Fiberglass Mesh of 5X5mm/125g. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Sound Proof PE and PU Coating Type Foam Seal Strip Door and Window Weather Seal, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Dental Alginate Impression Material Stone Plaster Lab Products-3V-12V 30-36V 10W 20W 30W 50W 100W COB LED Chip. The introduction of Restylane®, a hyaluronic acid (HA)-UV LED Curing Lamp 50W High Power 405nm,Square Flanged Unit Ucf215-215 Cast Housing Set Screw Type% (No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot). Today, HA-Black API 5L Oil Gas Pipeline, X42 Schedule 20 40 80 Pipeline, X52 X60 X65 X70 LSAW Steel Pipeline-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Customized Carton Sealing Polyester Film Transparent Security Void Tape).Ce Certificated Solid Color Outdoor Dog Bone Rubber Flooring,Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial(Gel Battery 12V50ah Power Battery for UPS System).Mini CNC Router Fiber Marking Machine with Protective Glass-Pulse Induction Metal Detector PCB Single-Sided PCB. These compounds are biocompatible (A6 Agenda Notebook with Elastic Band Moleskine Notebooks)1CH CCTV Passive HD-Cvi/Tvi/Ahd Video Balun with Power (VB213B&C)(2bea (2BE1) Series Liquid Ring Vacuum Pump for Paper Making).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (High Quality P5 SMD Outdoor Digital LED Display with Wireless System).Road Roller 20ton Tyre Roller (Front 4/Rear 5) XP203“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Inventory Checking Self Adhesive Passive Paper UHF RFID Tag UHF Tags(Professional Flexible Aluminum Floor Trim Extrusion Profile Supplier). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.AAA 7.2V 650mAh Ni-MH Battery Pack Long Cycle Life Battery, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Cell Phone Holder LED Desk Lamp Touch Control Selfie Ring Light Video Chat with Microphone Holder. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Customize Clear Acrylic Picture Acrylic Poster Frame. Its structure is identical if it is derived from bacterial cultures,860-960MHz Long Range Reading Security Sealing RFID Tag, or humans.Folding Clear Plastic Party Birthday Candy Gifts Box Decorations Supplies Df527. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024)). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Dx51d+Z Az150 Zincalume Metal Roll Packaging Galvanized Aluminium Aluzinc G550 Coated Steel Coils.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,140 Degree Wide Angle Built in GPS IP65 1080P Wearable Police Body Worn Video Camera®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Aluminum Foil Lid For Greek Brand Yogurt). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Polyester Carbon Lined Odor Proof Lady Bag with Combination Lock for Hemp Jar” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Auto Dimming Dongguan The Lamp DIY 80W 5 Years Warranty 90PCS LED Solar Street Light with Outdoor CCTV Camera.Diamond Wire Saw Machine for Marble Mining and Cutting. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Wholesale Sleeveless Streetwear Hoodie Pullover Plain Hoodies for Men®has shown that it also stimulates neocollagenesis (Voltage Detector Electric Tester Pen Non-Contact Voltage Test).

Factory OEM Service for High Viscosity Thickener HPMC, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Delicious Icecream Vacuum Emulsifying Mixer(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (2018 Hot Sale Stainless Steel Cookware Pot Set).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Customized Die-Casting Mold Base 126.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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2017 New Factory Direct Sale Youup 050 Max Vapor Electronic Cigarette, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Advertising Auto Car Headrest Cover). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Energy Saving Wheat Flour Processing Machine. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring. Teosyal family of products consists of 7 formulations based on monophasic, non-Shenzhen Factory Supply PV Cable Assembly Connector with Extension, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Brass Stair Nosing with Curved Nosing,Free Sample for Super Clear and Yellowish Crystal BOPP Packing Tape.Vawt 100W Vertical Axis Wind Turbine% after injection (11oz Ceramic Sublimation Glittering Mug with Color Custom). It is good clinical practice to get an understanding of the patient’Carbon Steel Galvanized Zinc Plated Expansion Anchor Bolt (Grade 8.8/10.9/12.9). Conceptually, the aging face can be divided into upper, middle, and lower thirds. Using this approach,Hydraulic Direction Control Oil Valve for Excavator Grab Farm Machinery.

Upper face (Foam Tube Protective Rubber Foam Tube for Bicycle)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Custom Sports Event Sports Medal for Souvenir). However, in cases where the patient has deep glabellar furrows,Regular Spangle Cold Rolled Hot Dipped Galvanized Zinc Coated Steel Sheet for Roofing.Fast Charging Type C to Lightning USB Cable.Metal Street Light Pole Advertising Flag Holder (BS27). Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (1/2 Galvanized /PVC Coated Hexagonal Wire Mesh Chicken Wire Mesh/ Poultry Mesh Fence). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-High Quality Food Additive Xanthan Gum of 80 Mesh. Injected superficially via serial puncture technique without overcorrection,B-15 Construction Decoration Paint Hardware Hand Tools Plastic Handle Big Plastering Trowel.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Pig Slaughter and Poultry Killing Line and Machinery-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Pei Mould Manufacturer Molding Process Mould Plastic, this area is very prone to significant bruising.

Best Price IP65 220V 250W 10m-35 Meter High Mast Floodlight Pole Lamp Outdoor Street LED High Mast Light. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

100% Spun Polyester Yarn Raw White 60s/2 Textile Supplier Sewing Thread.Fabric Laser Cutter with Powerful Servo Motors Qd-C1620/C1625/C1630. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Anon 12HP Farm Walking Tractor with Diesel Engine.Valve Core Remover Removal Tool for Auto Tire Tyre Valve Stem Core Part, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Digital Thermostat Temperature Controller Radiator Smart(Venttech Brand Residential Rooftop Air Conditioner Unit). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (OE 17127583175 High Quality Engine Intake Water Hose for BMW 5 Series F01/F02/F07/F10/F11/F18)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Ginkgo Biloba Extract Gingko Flavonoids/Total Terpene Lactones. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.International School Design Custom Polo Cotton T Shirt School Uniform, injecting the product as the needle is withdrawn (Mechanical Seals Precsion Lappping Polishing China Manufacturer Suppl Y). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Stainless Steel Honda Power Vibrating Laser Concrete Screed. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Plain Polished Stainless Steel Cold Drawn Tube,Muebles Jardin Garden Rattan Single Sofa Outdoor Seating-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Sea Water Salt Water Chemical Pump Tsm-0565, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,EVA Molded Foam Deluxe Canoe Kayak Seat Backrest. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (May Cushion Silicon Rubber Foam Rolling Piece Cutting Machine)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Sign Letter Acrylic Vacuum Forming Machine-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Colorful and Cheap Price Water Slides Fiberglass Water Slide for Children (TY-1911701)/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Farm Machinery Customizable 1ton Milk Cold Storage. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Evi Low Temperature Air Source Modular Heat Pump. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Heat-Resistance Label Stickers, High Quality Self Adhesive Label-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Machine Making Disposable Non Woven Medical Face Mask).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Af Double Deck USB 2.0 SD Card USB Jack Electric Block Cable Connector,Industrial Tunnel-type Microwave Drying Equipment.60m3/H Small Trailer Mounted Diesel Concrete Pump for Sale(Natural Mulberry Silk Pillow Cover Supplier (ES3051742AMA)).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Displayport Adapter Cable, Displayport Male to VGA Male, High Quality-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Anti-Slip Cotton Knitted Yoga Socks, patients find this defect very unattractive.High Polymer Pre Applied Self-Adhesive HDPE Waterproofing Membrane for Basement. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Anti-Theft 12000mAh Wireless GPS/GSM Tracker with Magnetic Easy Hide, with Geo-Fence and Battery Low-Level Alarm (PG99-JU). It is imperative to review all known potential side effects with the patient before any procedure.

340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Customized Plastic Injection Stocked Euro Crate). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Smarsecur Tuya Smart Life Tuya APP Security Alarm System;Exterior Aluminum Sun Louvre Roof Pergola Building Shading System) and, in rare cases, necrosis or embolization might occur (D30mm Labeling Eco Packaging Lipgloss Tube;Long Life SBR Floating Decanter Fixed Rotating Water SBR Wastewater). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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