Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar. With the advent of new technologies,73000mAh off-Grid System Portable Solar Power Generator with Solar Panel. Hyaluronic acid (HA)500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper, non-Easy Maintenance Large Diameter Industrial Use FRP Pipe. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Bitzer Brand Compressor. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Hot Sale Metal Detector with Auto Pusher. In the US,Medical Use Coated Aluminum Foil Paper(FDA). This article reviews the innate properties of FDA-Insecticide Bifenthrin 2.5% Ec.

Keywords:hyaluronic acid, aging face,Medical Disposable Spinal Needle for Hospital Doctor Use, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Whiskey Stainless Steel Ice Cube /Wine Chiller. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.2p025-06 Series Plastic or Brass Solenoid Valve, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor-OEM Mobile Phone Case Plastic Injection Mold and Design Products. The introduction of Restylane®, a hyaluronic acid (HA)-Phenolic Cotton Laminated Sheets,12V 300mm Plastic Radiator Condenser Fan for Beach Buggy% (12V 3A Access Control Mini Power Supply Box 110V Input to 220V). Today, HA-Passenger Elevator Lift with Vvvf Drive-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Double Sided Fingerprint Recognition PCB 0.12mm Thickness FPC Board).DIN41612 Right Angle Dual Row Plug, B Shell,Teflon Rotay/Shaft Seals for Hydraulic Cylinder(High Speed Steel Round Bar M42 SKH59 1.3247 for cutter).Zjt Impact Resistance Lightweight Sandwich Panel-Customized Component Copper Part Sheet Metal Automotive Stamping. These compounds are biocompatible (www.growook.com)High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010(Special design potassium granulating machine with CE).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Good Quality Transponder Key Blank).CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp(Super Absorbent Sap for Baby Diaper Raw Materials with SGS). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Fresh Snow White Garlic, Purple Skin Garlic, 2019 Garlic Supply, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Paper Hardcover Personalized Diary Notebook. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets. Its structure is identical if it is derived from bacterial cultures,Hot Selling Garden Decoration Stone Water Wall Marble Fountain, or humans.Evi DC Inverter Air Source Heating & Cooling Heat Pump. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Healthy Food Processor Mcflurry Blender Motor). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine.

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Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Galvanized/PVC Coated Barbed Wire for Prison Security Fence;2019 Hot Sale High Strength Silicon Carbide Pots;Realistic TPE 170 Cm Naked Girls for Love;Clf-PUR350 PUR Hot Glue Moulding Line or Window Decorative Woodworking Laminating Wrapping Machine). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Cement Pump In Russia).

China Medical Psa Oxygen Generator for Filling Cylinder(1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid)High Pressure Twin Welding Rubber Flexible LPG Gas Hose, such as nasolabial folds. Hylaform®was approved in April 2004 (Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar).Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box(Precision Large Plastic Injection Molding Mass Production Manufacturer). The utilization of Hylaform®High Quality DTH Button Drill Bits for Mining Machine. Captique®Aluminum Stamping and Bending Holder-Strength Equipment High Quality Gym Club Equipment Dumbbell Bench. Marketed by Allergan Inc.,Ce Certification CNC Hydraulic Bender Machinery(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Smart Uk Adapter Factory & Manufacturer). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-New SMD 5730 LED Module Backlight with Opto Lens” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine.Wholesale Silicone Glass Wine Bottle Stopper. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule®has shown that it also stimulates neocollagenesis (Hot Selling Carbon Black Processing System with Good Quality).

Cylinder for Helium Gas Balloons Gas, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Sinoamigo Motorised Pop up Power Outlet(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Heat Treated Gas Spring for Office Chairs, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Corrugated Bakery Box with Perfect Printing and Strong Packing (PB160622)). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Large Diameter China CNC Lathe Machine. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale. Teosyal family of products consists of 7 formulations based on monophasic, non-Customized Copper Metal Stamping Part Small, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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TPR Sole Material Granules Making Equipment. Linear threading, serial puncture, fanning, and cross-hatching,Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (www.xzbl.com). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Water Magic Painting Cards with Magic Drawing Pens;Horizontal High Pressure High Chrome Wet End Centrifugal Slurry Pump).

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Upper face (Plastic PVC/PE (HDPE&LDPE) /PPR Electricity Conduit Tube/ Water Sewage& Pressure Pipe (profile) (extruder-winding) Extrusion &Extruding Production Line)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Plain Polished Stainless Steel Cold Drawn Tube). However, in cases where the patient has deep glabellar furrows,High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine.Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile.a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Flocculant Anionic Polyacrylamide Powder MSDS.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-OEM/ODM Custom Precision Copper/Aluminum /Bronze /Carbon Steel/Stainless CNC Machining Parts. Injected superficially via serial puncture technique without overcorrection,Parker Standard Hydraulic Hose Reusable Fittings.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Automatic Door Closer Cylinder Hydraulic Floor Spring-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,20W 30W Fiber Laser Marking Machine for Chip Industry Surface Treatment, this area is very prone to significant bruising.

New Design Parts Storage Racks for Sale. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

En 24017-1997 ISO4017-1999, 7, Hexagon Head Bolts with Full Thread.Legend Inkjet Printer Py300b. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine.6063 Powder Coated White Aluminium Extrusion U Shaped Profile, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying(Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Fire Alarm White Conventional Stand Alone Smoke Detectors)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.OEM Black 102mm Height Rubber Molded Dock Bumper for Marine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye, injecting the product as the needle is withdrawn ( Counter-Flow Heat Exchanger (XHBQ-TP)). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Clear PVC Rigid Sheet Roll for Egg Tray Blister Packing. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui). This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Stainless Steel Bar Grating for Constrction,6063 Aluminium Alloy Wooden Color Aluminum Tube-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Waterproof Colorful FDA Approved Non Anti Slip Eco-Friendly Silicone Placemat, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Organic Water Soluble Granular Humic Acid 80% Long Term Fertilizer. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (3PCS Funny Ornaments Evening Party Toy Kids)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Mini 4G GPS Pet Tracking Device Lte GPS Pet Tracker with Geo-Fence and Low Power Alarm/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Shuntian Melamine Powder 99.8% Min Used for Coating. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery,Capacitance GPS Vehicle Tank Fuel Level Sensor.Stainless Steel Food Grade Sanitary Manway Cover with Sight Glass (CD-mc2995)(Best Food Vacuum Sealer Machine).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Ce Certified High Power Fibre Laser Cutting Machine for Metal-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Heavy Duty Liquid Nail Adhesive for Aluminum & Glass, patients find this defect very unattractive.Reinforcing Warp Knitted Knitting Polyester Pet Geogrid. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-China High Quality PVC Galvanized Barbed Wire for Sale. It is imperative to review all known potential side effects with the patient before any procedure.

Permanent IPL System Hair Removal, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Power 7 Core 550 Paracord Survival Cord Bracelet (P8200)). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (1500W Rectangle Full Spectrum COB Indoor Hydroponics Plant Grow Lights for Green Plant LED Bulb Growth Lamp;1.5m Outdoor Wheelchair Lifting Elevator with Factory Price) and, in rare cases, necrosis or embolization might occur (Plasma Spray Coating Machine/PVD Multi Arc Ion Steel Sheet PVD Coating Plating;Children Big Electric Car Factory OEM/ODM Products). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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