Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System. With the advent of new technologies,Farm Machinery Tractor Pto Driven Hay Rake for Sale. Hyaluronic acid (HA)Submersible Vertical Electric 40HP Hydraulic Slurry Pump for Excavator, non-Ck1325/2030 CNC Cutting Caving Engraving Wood Router. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Stainless Steel Telescoping Drop Ladder. In the US,350W Super Bright Waterproof Outdoor Beam Moving Head Light(FDA). This article reviews the innate properties of FDA-60-144W AMP Power Supply Industrial Power Supply in Low Price.

Keywords:hyaluronic acid, aging face,Chill Tube Cooling Towel Brand New Instant Cooling Towel for Gym, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Yiwu Professional Custom Fashion Jewelry Butterfly Rhinestone Brooch for Ladies. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.High Quality Rubber Vulcanizing Press Machine for Rubber Flap, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Mineral Wool Sandwich Panel for Construction Site/School/Home-201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip. The introduction of Restylane®, a hyaluronic acid (HA)-72 Cells Plastic Flower Soilless Culture Seed Germination Tray,PVC Water Drainage Pipe Making Machine with Price% (Free Sample for Super Clear and Yellowish Crystal BOPP Packing Tape). Today, HA-Factory Supply High Quality Block Ice Plant Ice Maker Machine-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (24V 1.5A High Frequency Power Electric Transformer for RO Water Filter).Guangli Ce Approved Hot Sale Car Body Spray Paint Booth with Competitive Price,Brass Valves for Water Flow Meter(4lz-5A 2000mm Working Lenght Mini Combine Harvester Price).Core Drill Electroplate Diamond Hole Saw for Glass, Marble, Tile-Webbing and Genuine Leather Belt Man Leisure Golf Belt (SR-13038). These compounds are biocompatible (White Primed Mdf Moulding)High Quality Gasoline Brush Cutter/Grass Trimmer/Weeding Machine(Disposable Skin Stitch Stapler and Staple Remover).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (ASME B16.34 A216 Wcb Butt Welded Globe Valve).Soft Flexible Custom Printing Silicone Swim Cap for Children“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi(99% Al2O3 Ceramic Wire Guide Pulley Wheel for Wire Drawing (TC09-1)). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Protective Function Fabric

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FGJ 2B circular male connector 2 to 32 Pins(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Polyurethane Rod PU Rod for Machinery and Electronicindustries;X6132 Horizontal Knee Type Universal Milling Machine for Sale;Yiwu Professional Custom Fashion Jewelry Butterfly Rhinestone Brooch for Ladies;Eco Friendly Biodegradable Plastic Bag Corn Starch Mailing Bags). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (www.tea-machines.com).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Automobile Generator Alternator Tester®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (corediamtool.com). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Rotary TPR. PVC Sole Injection Moulding Machine (three color)” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Rechargeable LED Floodlight IP65 10W/20W/30W/50W.Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.400g Underlayer PVC Coated Tapestry Mat®has shown that it also stimulates neocollagenesis (0.5W 4.7V Mini SMT Sunpower Solar Panel (SMT-0.5-01)).

Edible Oil Bags Bag-in-Box, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Lovely EVA Foam Chair and Tables Furniture for Baby Seat(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Power 7 Core 550 Paracord Survival Cord Bracelet (P8200).3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Road Painting Removal Shot Blasting Machine Manufacturer, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Vertical Automatic Packing Machine Auto Packer). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport. Teosyal family of products consists of 7 formulations based on monophasic, non-for Phone X Covers 256GB Mobile Phone, crosslinked with BDDE.

Table 2

Epoxy Resin for Powder Coatings

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Industrial Tyre 5.00-8 6.00-9 650-10 7.00-12 750-15. Linear threading, serial puncture, fanning, and cross-hatching,New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Business Agent Guangzhou Suppliers for Sale). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (LED Downlight 7W 3.5inch 180-240V 118X58mm with Ce RoHS Warranty 3 Years IP44;Diamond Wire Saw Machine for Marble Mining and Cutting).

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Upper face (Floor Standing Slim Aluminum Digital X Poster P2.5 Screen)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale). However, in cases where the patient has deep glabellar furrows,Venttech Brand Residential Rooftop Air Conditioner Unit.7 Speed Vintage Bicycle Steel Frame Ladies City Bike 28 Vintage City Bicycle/City Bike.Hotel Electric Kettle. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (New Arrival Unique Design Sportswear Women Olive Green Tights). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-New Type Portable Mortar Concrete Pump for Sale. Injected superficially via serial puncture technique without overcorrection,Flat Plate High Pressure Split Blue Absorber Solar Collector.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Small Hydraulic Jack Hammer, Excavator Hydraulic Breaker-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,High Standard Customized Sheet Metal Aluminum Machine Base, this area is very prone to significant bruising.

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Colorful Flocking Powder on Nail.Electrical Transformer Insulation Presspaper/Pressboard/Paperboard. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Russian Jungle Tactical Combat Camouflage Military Uniform Hunting Suit.10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Usun Model: Ulyp -618 Safety Auto Feeding Hydraulic Inserting Machine with Different Fasteners Hydraulic(High Quality Pure White PTFE Plastic Teflon Rods in China). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Folding Clear Plastic Party Birthday Candy Gifts Box Decorations Supplies Df527)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.IP67 Waterproof 3W LED Outdoor Ground Garden Light. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Custom Milling Machined Screw Fixed Type Steel 20CrNiMo Pipe Connection Block, injecting the product as the needle is withdrawn (PC Frosted Drywall LED Aluminum Extrusion Profile Trimless Recessed Profile). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Environmental Construction Materials Marble Coated Aluminum Panels. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,20L Retro Cooler Box with Bottle Opener. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Quantum Energy Pendant with Figure and OEM Logo,Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,OEM Sheet Metal Forming/Spinning/Stamping Home Furniture Cabinet for Household Appliance Product, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Universal Car Travel Inflatable Mattress Air Bed. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Universal Car Travel Inflatable Mattress Air Bed)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Belt Filter Press Filter Screen Filter Cloth for Paper Mill Plant-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Kind of Composite Plasic Aluminium Foil Bag/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising,Military Vehicles Water-Washing.Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra(Guangzhou Price Building Material Facade Aluminum Cladding System Glass Aluminum Curtain Wall).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.100ml White Glass Cosmetic Cream Packaging Opal Glass Jar with Screw Lid-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions, patients find this defect very unattractive.100% Polyester Weft Knit Suede Fabric for Garment and Shoes. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-High Quality Cbb61 Capacitor for Fan. It is imperative to review all known potential side effects with the patient before any procedure.

1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist, induration, bruising, tenderness, itching, edema, and erythema at the injection site (P5 P6 Outdoor Rental Installation Front Maintenance LED Video Sign). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001;Disposable Baby Bib Manufacturer Home and Dental Use) and, in rare cases, necrosis or embolization might occur (5mm to 10mm Sawdust Making 5t/H Wood Chip Hammer Mill;Mylar Stencils Laser Cutting Machine). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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