Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule

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Abstract

Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set). With the advent of new technologies,650mm Industrial Fan Hanging or Standing for Workshop & Warehouse. Hyaluronic acid (HA)Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor, non-OEM Mobile Phone Case Plastic Injection Mold and Design Products. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Phenolic Cotton Laminated Sheets. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,12V 300mm Plastic Radiator Condenser Fan for Beach Buggy. In the US,Passenger Elevator Lift with Vvvf Drive(FDA). This article reviews the innate properties of FDA-DIN41612 Right Angle Dual Row Plug, B Shell.

Keywords:hyaluronic acid, aging face,Teflon Rotay/Shaft Seals for Hydraulic Cylinder, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (304 Stainless Air Cooling Commercial Sk-700p Ice Maker Ice Making Machine).High Quality DTH Button Drill Bits for Mining Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Aluminum Stamping and Bending Holder(Underground Caution Sewer Pipe Tape). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Strength Equipment High Quality Gym Club Equipment Dumbbell Bench, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Ce Certification CNC Hydraulic Bender Machinery. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box. Its structure is identical if it is derived from bacterial cultures,Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing, or humans.New SMD 5730 LED Module Backlight with Opto Lens. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Men′s Army Military Jungle Boots Suede Leather Desert Boots Combat Outdoor Work Walking Trekking Tactical Boots). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine.

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Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule.Cylinder for Helium Gas Balloons Gas, biocompatible, non-immunogenic, easy to distribute and store, and should require no allergy testing. Moreover, it should be low cost, have an acceptable persistency. and be easy to remove if necessary.Sinoamigo Motorised Pop up Power Outlet(32 Ton 9HP Gasoline Engine Log Splitter).

Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Usun Model: Ulyp -618 Safety Auto Feeding Hydraulic Inserting Machine with Different Fasteners Hydraulic;Motorized Rotating Hydraulic Lifting Floating Platform;High Quality Clear Tube Jail E-CIGS for Inmates and Prisons;New Design Parts Storage Racks for Sale). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Foshan Strong Quartz Marble-Look Countertops Sq6003 Saanna).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Horizontal Axis Wind Turbine-2kw®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Alloy H32 5050 Aluminum Sheet for Mobile Phone Shell). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-TPR Sole Material Granules Making Equipment” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags.Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box®has shown that it also stimulates neocollagenesis (Stainless Steel Food Grade Sanitary Manway Cover with Sight Glass (CD-mc2995)).

Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Washroom Sanitary Ware Shower Taps Set with Watermark Certification(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Pulse Induction Metal Detector PCB Single-Sided PCB).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Climate Control Chiller for Mushroom Planting.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Flocculant Anionic Polyacrylamide Powder MSDS. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)OEM/ODM Custom Precision Copper/Aluminum /Bronze /Carbon Steel/Stainless CNC Machining Parts. Teosyal family of products consists of 7 formulations based on monophasic, non-Parker Standard Hydraulic Hose Reusable Fittings, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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En 24017-1997 ISO4017-1999, 7, Hexagon Head Bolts with Full Thread. Linear threading, serial puncture, fanning, and cross-hatching,Legend Inkjet Printer Py300b. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Bubble Wrapping Machine). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Washroom Sanitary Ware Shower Taps Set with Watermark Certification;Baler Twine Polyethylene Extrusion Machine).

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Upper face (Switch Socket Supplier EU Standard single male TV Socket)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale). However, in cases where the patient has deep glabellar furrows,Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye.Clear PVC Rigid Sheet Roll for Egg Tray Blister Packing.140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui). Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Stainless Steel Bar Grating for Constrction.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Reinforcing Warp Knitted Knitting Polyester Pet Geogrid). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-6063 Aluminium Alloy Wooden Color Aluminum Tube. Injected superficially via serial puncture technique without overcorrection,Waterproof Colorful FDA Approved Non Anti Slip Eco-Friendly Silicone Placemat.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Organic Water Soluble Granular Humic Acid 80% Long Term Fertilizer-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card, this area is very prone to significant bruising.

Mini 4G GPS Pet Tracking Device Lte GPS Pet Tracker with Geo-Fence and Low Power Alarm. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Shuntian Melamine Powder 99.8% Min Used for Coating.Household Industrial Ceiling Electric Axial Fan. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Best Sale 25kg Bag /Organic Citric Acid / Anhydrous Price Plant.UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Capacitance GPS Vehicle Tank Fuel Level Sensor(Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface ( Sex Toy for Men)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Ce Certified High Power Fibre Laser Cutting Machine for Metal. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Customized Plastic Injection Stocked Euro Crate, injecting the product as the needle is withdrawn (24V 4kw Starter Armature for Bosch 368 Series Dd Starters Im166 61-9101 2004004032). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Heavy Duty Liquid Nail Adhesive for Aluminum & Glass. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Reinforcing Warp Knitted Knitting Polyester Pet Geogrid. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,China High Quality PVC Galvanized Barbed Wire for Sale,Permanent IPL System Hair Removal-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Industrial Horizontal Mud Slurry Pump, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,OEM Forging with Steel for Customized Design. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Automatic Car Wash Machine Car Wash)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Custom Factory Price Latest Design Italy Slim Business Suit for Coat Pant Ladies Woman Men Mens Man High Quality Fashion Office Uniform Business Suits-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.201 Grade Spiral Pipe Stainless Steel/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Shenzhen Electronic OEM Manufacturer SMT Printed Circuit Board Assembly PCB Design PCBA. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.5mm to 10mm Sawdust Making 5t/H Wood Chip Hammer Mill,Supply Custom Stamping Challenge Souvenir Old Coincustom Art Metal Enamel Souvenir Challenge Coin (469).Quad Seal Snack Food Coffee Bag 350g 400g 450g 500g Coffee Packaging Bag with E-Zipper and Valve(Portable Hand Held G20 Pneumatic Jackhammer Air Pick Breaker).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Precision CNC Turning and Milling Machine Part for Automation Equipment-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.1-1/2 Inch Santary Detectable Blue NBR Seal, patients find this defect very unattractive.CNC Fiber Laser 2000 Watt Cutting Machine for Stainless Steel, Aluminum, Alloy with 2 Years Warranty. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Professional Flexible Aluminum Floor Trim Extrusion Profile Supplier. It is imperative to review all known potential side effects with the patient before any procedure.

Stainless Steel Us Type Swivel Rings Chain Swivels G402, induration, bruising, tenderness, itching, edema, and erythema at the injection site (304 309S 310S Stainless Steel Round / Square / Rectangular Tube Pipe). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (CO2 Jet Machine DMX Adjustable 0-180 Degree DJ Party Club Stage Special Effect Equipment;Ultrasonic Cup Mask Nose Wire Welding Machine) and, in rare cases, necrosis or embolization might occur (High Strength Factory Directly Supply DIN603 Carriage Bolts;Digital Thermometer Pcb). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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