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Abstract
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Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe).Acrylic/Plastic/Wood /PVC Board/1600*1000 CO2 Laser Cutting Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
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Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.2-Way Brass Electric Valve Ball AC220V Dn25 1. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
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Table 1
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US FDA approved products | Company |
---|---|
Hylaform | Genzyme |
Hylaform Plus | Genzyme |
Captique | Genzyme |
Restylane | Medicis Aesthetics |
Juvederm Ultra | Allergan, Inc |
Juvederm Ultra Plus | Allergan, Inc |
Perlane | Medicis |
Elevess | Anika therapeutics |
Presently,Dust Resistance Oil Resistance PVC S Floor in Roll®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Educational Prepared Slides Wholesaler Quotes & PriceList). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,Cubic Zirconia 925 Silver Freshwater Pearl Pendant Necklaces.Honeycomb Active Carbon for Removal of Benzene Air Cleaning. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods®has shown that it also stimulates neocollagenesis (B87 Air Jack Hammer Drill Rod for Drilling Equipment).
Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Diameter 12mm Green LED Pixel Light(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Grey Faux Marble Artificial Quartz Stone Slabs.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Ultrasonic Cup Mask Nose Wire Welding Machine, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Watertight Aluminum Alloy Brick Wall Expansion Joint Cover). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Wrench Zinc Plated Hand Tools. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Steel Downpipe Rolling Forming Machine. Teosyal family of products consists of 7 formulations based on monophasic, non-Knock Sensor Lada 18.3855 183855, crosslinked with BDDE.
Table 2
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Product | Company |
---|---|
Teosyal | Teoxane, Switzerland |
Puragen Plus | Mentor, CA, USA |
Prevelle | Mentor, CA, USA |
Belotero | Merz pharmaceuticals, NC, USA |
New Net Shoes Breathable Soft Sole Sport Shoes Men.PVC Drainage Pipe Extrusion Production Machine. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.
FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall. Linear threading, serial puncture, fanning, and cross-hatching,1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Plant Extract Tea Polyphenol (CAS No: 84650-60-2)). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood;New Product Electric Indicator Lamp with Ce).
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Upper face (Industrial Manual Lift Vacuum Rotary Evaporator)
Table 3
Preferred hyaluronic acid products for the upper face
Area | |
---|---|
Glabellar | Restylane |
Forehead | Restylane |
Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Water Filling Machines). However, in cases where the patient has deep glabellar furrows,Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe.Brass Fire Hydrant Landing Valve 21.Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Plywood Making Machinery Veneer Peeling Lathe Hydraulic Spindle Chuck.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles. Injected superficially via serial puncture technique without overcorrection,Factory High Quality Electro Galvanized Binding Wire in Competitive Price.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD, this area is very prone to significant bruising.
PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.
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Midface (2019 Tie on Non Woven Disposable Medical Surgical Cap Machine)
Table 4
Preferred hyaluronic acid products for the midface
Area | |
---|---|
Cheeks | Perlane |
Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Tri-Screw Extruder for Powder Coating, injecting the product as the needle is withdrawn (Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Cma-Cgm Cargo Transportation From China to Worcester, Ma. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Baghouse Industrial Dust Collector Manufacturer. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,50mm Extruded Polystyrene Insulation Board,Underground Caution Sewer Pipe Tape-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,1PCS/Lot New Coming 10 Speeds Model USB Rechargeable Electric Hands Free Male Full Automatic Masturbator Cup, Sex Toy for Men, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,China Factory Perfume Bottle of Competitive Price. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face ( Cat Collar)
Table 5
Preferred hyaluronic acid products for the lower face
Area | |
---|---|
Perioral | Restylane |
Lips | Juvederm Ultra |
Crease of chin | Juvederm Ultra |
Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Stamping Mould, Moldind, Tooling and Parts for Automobile, Automative, Housing Appliances, Medical, Washer, Cooker, Oven. Auto Parts./or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024). This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Xr/Yr8 Colors Printing Machine,Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline.Mens Women Custom Gym Bag with Shoe Compartment(m.hyrubbers.com).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Pump Spray Perfume Plastic Spray Bottle-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board, patients find this defect very unattractive.Breathable PU Sole Steel Toe Safety Shoes. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids. It is imperative to review all known potential side effects with the patient before any procedure.
Customizing Galvanized Gestation Sow Stalls Made in China, induration, bruising, tenderness, itching, edema, and erythema at the injection site ( Stovetop). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Fractional Microneedle RF Machine Face Lift and Wrinkle Reduction with Cooling Head;Brass Fire Hydrant Landing Valve 21) and, in rare cases, necrosis or embolization might occur (Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin;48v Pwm Solar Inverter). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:6 Ounce Stainless Steel Thermos Flask Drinking Bottle.
- Mobile Phone Holder CO2 Laser Engraving Cutting Machine, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts][New Net Shoes Breathable Soft Sole Sport Shoes Men]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring]
- Hex Bolt DIN933 Hex Bolt DIN931, Cazzaniga A.OE 17127583175 High Quality Engine Intake Water Hose for BMW 5 Series F01/F02/F07/F10/F11/F18: Restylane and Perlane. In: Maas CS, editor.Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [ASTM B338 High Quality Welded Medical Treatment Titanium Pipe][860ml Glass Juice Bottles with Tin Lids]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[GPS Tracker Watch Df27 Waterproof Kids Smart Watch Mobile Phone Sos Call Finder Locator Tracker Anti Lost Monitor][Paper Mill Corrugated Cardboard Making Machine Kraft Paper Machine]
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- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)Stainless Steel Sintered Filter Tube 18(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[5PCS Heavy Duty 2.5 Inches Office Chair Caster Wheels Replacement for All Floor & Carpet (OCC25)][Durama Brand Hydraulic CNC Press Brake with E21 Controller]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards][Stainless Steel Precision Conveyor System Welded Tube]
- Coleman KR, Carruthers J.4′′ Stainless Steel Diaphragm Seal Pressure Gauge: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[Roof Membrane][CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts]
- Coleman SR, Grover R. The anatomy of the aging face:PPR Double Female Thread Elbow for Bathroom-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[Mesh Milanese Stainless Steel Wristwatch Band 1.0mm][Stainless Steel Sintered Filter Tube 18]
- De Maio M. the minimal approach:Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts.Aesthetic Plast Surg.2004;28:295–300.[Wholesale Nameplate Custom Design Metal Engraved Logo][New Prep Bay with Side PVC Curtains with Raised Metal Floor with Extraction Fans Prep Station]
- Duranti F, Salti G, Bovani B, et al.Sc/APC Singlemode, Simplex Adapter with Shutter, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang][Warehouse Storage Transportation Stacking Steel Metal Pallets]
- Fernández-Cossío S, Castaño-Oreja MT.Pet Tablet Bottles with Child Resistant Cap:Ivory White 4FT*8FT External Wall Aluminum Facade Panel.Plast Reconstr Surg.2006;117:1789–96.[ASTM A240 316L ASME SA 240 304 Stainless Steel Plate][Large Rosewood High Gloss Piano Finish Wooden Cup Base]
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