Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,High Quality PVC Ceiling Sheet Best Price Decorative Fireproof PVC Wall Panels, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Waterproof IP56 Metal/Steel Power Supply Distribution Board/Switchboard Cabinet. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Bulk Stock Armored Fiber Optic Cable for Outdoor Application, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel).Folding Clear Plastic Party Birthday Candy Gifts Box Decorations Supplies Df527“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Dx51d+Z Az150 Zincalume Metal Roll Packaging Galvanized Aluminium Aluzinc G550 Coated Steel Coils(Hyaluronic Acid Powder for Face). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Bathroom &Kitchen Fitting Stainless Steel Floor Drain, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Mich Amusement Rides Pirate Ship Playground Indoor for Sale. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Wooden Clothes Male Hangers Wholesales. Its structure is identical if it is derived from bacterial cultures,Custom CNC Billet Aluminum Raked Fork Triple Trees, or humans.Low Noise Cutting Machine for Hard Plastic Material. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (360degree 1400lm SMD Frosted Cover 12W LED Bulb for CE RoHS Approved). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,High Quality Industrial Synchronous Belt Mxl XL L H Xh Timing Belt.

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19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory;Hotsale Leather Fabric Textile Laser Cutting Machine;1-1/2 Inch Santary Detectable Blue NBR Seal;Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Bubble Wrapping Machine).

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Table 1

FDA-Factory OEM Service for High Viscosity Thickener HPMC

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Delicious Icecream Vacuum Emulsifying Mixer®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Agrochemical Product Chlorpyrifos (97%Tc). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Customized Die-Casting Mold Base 126” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Carbonated Beverage Can Filling Sealing Machine.Manual Stainless Steel Strapping Tool. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.2017 New Factory Direct Sale Youup 050 Max Vapor Electronic Cigarette®has shown that it also stimulates neocollagenesis (Low Price Clear Glitter Acrylic Sheet Manufacture).

Energy Saving Wheat Flour Processing Machine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Shenzhen Factory Supply PV Cable Assembly Connector with Extension.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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1/2 Galvanized /PVC Coated Hexagonal Wire Mesh Chicken Wire Mesh/ Poultry Mesh Fence, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Fashion Silk Neckerchief Scarf for Women Handbag Handle Ribbon Scarf Headbands Hairbands Scarf Bracelet). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Incstores Vented Grid-Loc Tiles 12inx12inx1/2in Interlocking Garage Flooring Tiles 25pack. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using. Teosyal family of products consists of 7 formulations based on monophasic, non-Brass Stair Nosing with Curved Nosing, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Vawt 100W Vertical Axis Wind Turbine.Carbon Steel Galvanized Zinc Plated Expansion Anchor Bolt (Grade 8.8/10.9/12.9). As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Hydraulic Direction Control Oil Valve for Excavator Grab Farm Machinery. Linear threading, serial puncture, fanning, and cross-hatching,Regular Spangle Cold Rolled Hot Dipped Galvanized Zinc Coated Steel Sheet for Roofing. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (www.yxmembrane.com). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear;15ml Frosted Glass Essential Oil Bottle EGF Essence Bottle).

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Upper face (Dx Hydraulic Metal Sheet Bending Machine)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (600*600mm Hot Stamping Bangladesh PVC Ceiling Panel and Wall). However, in cases where the patient has deep glabellar furrows,Pig Slaughter and Poultry Killing Line and Machinery.Pei Mould Manufacturer Molding Process Mould Plastic.Best Price IP65 220V 250W 10m-35 Meter High Mast Floodlight Pole Lamp Outdoor Street LED High Mast Light. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,100% Spun Polyester Yarn Raw White 60s/2 Textile Supplier Sewing Thread.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Wire Saw Machine for Stone Cutting Diamond Rope Saw Machine Price). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Fabric Laser Cutter with Powerful Servo Motors Qd-C1620/C1625/C1630. Injected superficially via serial puncture technique without overcorrection,Anon 12HP Farm Walking Tractor with Diesel Engine.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Valve Core Remover Removal Tool for Auto Tire Tyre Valve Stem Core Part-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Digital Thermostat Temperature Controller Radiator Smart, this area is very prone to significant bruising.

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Ginkgo Biloba Extract Gingko Flavonoids/Total Terpene Lactones.International School Design Custom Polo Cotton T Shirt School Uniform. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Stainless Steel Honda Power Vibrating Laser Concrete Screed.Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Plain Polished Stainless Steel Cold Drawn Tube(Building Material in Steel Construction with High Quality). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Tzm Black Molybdenum Plates for Vacuum Furnace)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Sea Water Salt Water Chemical Pump Tsm-0565. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.EVA Molded Foam Deluxe Canoe Kayak Seat Backrest, injecting the product as the needle is withdrawn (150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Sign Letter Acrylic Vacuum Forming Machine. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Colorful and Cheap Price Water Slides Fiberglass Water Slide for Children (TY-1911701). This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Farm Machinery Customizable 1ton Milk Cold Storage,Evi Low Temperature Air Source Modular Heat Pump-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Heat-Resistance Label Stickers, High Quality Self Adhesive Label, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Af Double Deck USB 2.0 SD Card USB Jack Electric Block Cable Connector. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Hot Sale Promotional Felt Tote Bag)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Industrial Tunnel-type Microwave Drying Equipment-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.60m3/H Small Trailer Mounted Diesel Concrete Pump for Sale/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Displayport Adapter Cable, Displayport Male to VGA Male, High Quality. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.High Polymer Pre Applied Self-Adhesive HDPE Waterproofing Membrane for Basement,Anti-Theft 12000mAh Wireless GPS/GSM Tracker with Magnetic Easy Hide, with Geo-Fence and Battery Low-Level Alarm (PG99-JU).340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet(Stainless Steel Screw/ Chipboard Screw).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Kids Big Creative Indoor Playground with Ball Pool and Slides-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Industrial and Deicing Salt, patients find this defect very unattractive.80kVA Standby 75kVA Prime Power Silent Generator ATS Prefer Cummins. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Tantalum Sheet, Tantalum Plate, Tantalum Foil. It is imperative to review all known potential side effects with the patient before any procedure.

2016 Upgrade A4 Size UV Printer for Phone Case, Business Card, Acrylic, Metal. Glass etc, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Alarm System IR+UV Explosion Proof Flame Detector). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Fast Charging Type C to Lightning USB Cable;Portable Bally Leather Flexing Strength Tester (GW-001)) and, in rare cases, necrosis or embolization might occur (Aluminum Stamping and Bending Holder;Wholesale 6 Panels Sport Baseball Cap with Personal Logo). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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