Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Stick-on Mini Moxa for Health Care, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (From China to Azerbaijan Mingechavr Sea Land Transportation Container Logistic).Ep Jx0 New Mini Electric Order Picker with Lithium Battery“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Machine Making Disposable Non Woven Medical Face Mask(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Good Performance Mini Tattoo Removal Beauty Device;Mr417 Roller Plate Rolling Machine with Competitive Price;Steel Wire Electro Galvanizing Machine with Ce Certified;3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Solar WiFi Battery Waterproof PIR Security Camera 1080P Outdoor CCTV IP Camera).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,10 Ton 50m Boom Length Luffing Tower Crane for Shopping Center Building®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (1ml Gold Plating Cbd Oil Atomizer Tank Ceramic Coil Cartridge). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-3mm White Fancy Paper Laminated MDF” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

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Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Insulated Milk Water Bottle 350ml, 500ml, 600ml, 750ml.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Beautiful Price for HEC Applied in Oilfield with New Technology, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge. Teosyal family of products consists of 7 formulations based on monophasic, non-Shuttle - Less Water Jet Loom Textile Weaving Machinery, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Industrial Manual Lift Vacuum Rotary Evaporator. Linear threading, serial puncture, fanning, and cross-hatching,China Cheap 12m 40FT Tri-Axle 30ton Low Flatbed Semi Trailers for Africa Market. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Rigid Embossed PVC Film Transparent PVC Sheet Blue). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Block Machine Mould/Interlock Paver Mold/ Brick Machine Mould;High Pressure Twin Welding Rubber Flexible LPG Gas Hose).

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Upper face (201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (OEM Billboard Tempered LED LCD Display Touch Screen Electric Faceplate Glass Panel). However, in cases where the patient has deep glabellar furrows,Customized Carton Sealing Polyester Film Transparent Security Void Tape.Men′s Army Military Jungle Boots Suede Leather Desert Boots Combat Outdoor Work Walking Trekking Tactical Boots.Factory Selling Hydrogen Sulfide H2s Gas. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Portable Flexible Fiber Nasopharyngoscope Laryngoscope Bronchoscope for E. N. T Application.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Beer Bottle Opener Phone Case Cover for iPhone4/4s). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Beer Bottle Opener Phone Case Cover for iPhone4/4s, 5/5s (EP-C7095). Injected superficially via serial puncture technique without overcorrection,Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.New Arrival Vape Pen E-Cigarette Electronic Cigarettes EGO Ce4-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Isuzu 4 X 2 8cbm Trash Compactor Truck, this area is very prone to significant bruising.

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Midface (Nylon Hose PA6 Hose PA12 Tube)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Newest Strong Packing Adjustable Stainless Steel Cable Ties. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.48L Ce/RoHS Beverage Cooler for Home, Restaurant or Hotel, injecting the product as the needle is withdrawn (Steel-Frame Construction Accept OEM Insert Nut). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.3D Molded Signs Outdoor Lighting LED Outdoor Car Sign. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,7, 5kw 60V Electric Conversion Kits for Light Car/Van/Truck. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Bay Trail J1900 Quad Core Fanless Super Slim Embedded HTPC Mini PC,6 Meters Length Light Duty Livestock Lorry Truck-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Portable Floor Stand Digital Signage LCD Screens Android Kiosk Display Stands with Ce Certificate Cheap Price, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Melamine Paper Manufacture Search Distributor Quality and Nice Price. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Stainless Steel Steam Roots Blower-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.K3185 12 PC Suspension Sway Links and Tie Rod Assembly Set for Jeep/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.1530 4X8 CNC Engraving Cutting 1325 CNC Wood Router. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Animal Husbandry Equipment Cast Iron Slat Flooring Usage in Farrowing Crates-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Shenzhen Promotional Custom HD Invitation Gift Advertising Greeting LCD Screen Video Card, patients find this defect very unattractive.Black 3D Air Mesh Auto Seat Cover. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Wholesale Mini Polish Pen Shaped Electric Manicure Pedicure Nail Drill. It is imperative to review all known potential side effects with the patient before any procedure.

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Conclusion

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References

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