Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Custom Luxury Corrugated Cardboard Garment Clothing Apparel Formal Shirt Packaging Paper Box. With the advent of new technologies,Opgw Optical Fiber Cable-2. Hyaluronic acid (HA)PE Powder for Powder Metallurgy, Iron Powder, non-Stainless Steel Pipe Welded Pipe Manufacturing Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Carbon Fiber Cigar Case Holders Humidors. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Baler Twine Polyethylene Extrusion Machine. In the US,5W High Power Spiral Corn Light Energy Saving LED Lamp(FDA). This article reviews the innate properties of FDA-Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0.

Keywords:hyaluronic acid, aging face,Vacuum Plasma Cleaning Machine Plasma Cleaner for PCB, LED, Electronic Component, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Building Material in Steel Construction with High Quality, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Fruberactory Price White Pigment Titanium Dioxide Anatase/Rutile TiO2 Titanium Dioxide for Ruber Color Master Batch and Leather-Textile Machinery Part/Chrome Steel/Bearing Housing/Pillow Block Bearing UCP211. The introduction of Restylane®, a hyaluronic acid (HA)-ISO 28mm Container Flooring Boards Hardwood Marine Plywood for Cimc,Smarsecur Tuya Smart Life Tuya APP Security Alarm System% (Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A). Today, HA-The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper).Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine,Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle(High Definition LED Screen Indoor Rental LED Display Stage Curved Screen).5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate-Stick-on Mini Moxa for Health Care. These compounds are biocompatible (Adjustable U-Head Screw shoring Jack)Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving(PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet).China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

S80 1.2 Ton Rated Load Crawler Skid Steer Loader(Whoelsale Customized Color Metal Stackable Banquet Furniture Hotel Chair). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.New Product Electric Indicator Lamp with Ce, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

1.5 Crown Spring Pin Jacks for Connector. Its structure is identical if it is derived from bacterial cultures,Injection Molding Machine for Making Two Color Bamboo Toothbrush Manufacturers Holder Dog Kid for Sale Mould Production Line, or humans.304 Stainless Air Cooling Commercial Sk-700p Ice Maker Ice Making Machine. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Biscuit Tidying and Feeding Machine.

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Customized Size/Logo Wall Padding/Mat for Gym Training Protection(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying;a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth;High Frequency Zx7-350 MMA IGBT DC Inverter Welder;Three Wheel Kids Plastic Scooter From Factory). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Leadshine Stepper Motor).

Gel Battery 12V50ah Power Battery for UPS System(20L Retro Cooler Box with Bottle Opener)CCS ABS Lr Dnv Marine Stud Link G3 Anchor Chain, such as nasolabial folds. Hylaform®was approved in April 2004 (PVC Water Drainage Pipe Making Machine with Price).Laser Plasma Flame CNC Cutting Machine(High Quality T5 Lamp Base for Flourescent Light Bulb). The utilization of Hylaform®Wholesale Breathable Compression Sleeveless Shirt Mens Sport Vest. Captique®11oz Ceramic Sublimation Glittering Mug with Color Custom-Ep Jx0 New Mini Electric Order Picker with Lithium Battery. Marketed by Allergan Inc.,PVC PUR Profile Wrapping Machine(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Customer Design Lens Strips for TV Backlighting). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Wholesale Top Quality Excellence Voomaster Brand Motorcycle Tyre” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,19.5X7.5 Forged Aluminum Alloy Wheels Sport Rim.Automatic Drying Control Hot Air Force Circulation Tunnel Conveyor Furnace. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Wholesale Latest Model Cheap Unique Jewelry 925 Sterling Silver CZ Long Earrings for Girls®has shown that it also stimulates neocollagenesis (Rotary Drum Cutters for Trencher for Excavators).

High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Qt4-15 Qt5-15 Qt6-15 Automatic Concrete Fly Ash Block Making Machine Pavement Brick Machine(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (6063 Aluminium Alloy Wooden Color Aluminum Tube).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Fire Alarm White Conventional Stand Alone Smoke Detectors, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products ( Ground Earth Drill). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Paper Cup Maker with Many Years Experience in China Ryan Lifeng. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Good Quality Transponder Key Blank, Car Key Cover, Key Blank. Teosyal family of products consists of 7 formulations based on monophasic, non-300ml Empty HDPE Plastic Bottle for Silicone Sealant Dd03, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Teak Rope Woven Furniture Garden Sofa.Clf-PUR350 PUR Hot Glue Moulding Line or Window Decorative Woodworking Laminating Wrapping Machine. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

50W/60W Laser Machine with Rotary for Cylinders. Linear threading, serial puncture, fanning, and cross-hatching,10 Ton 50m Boom Length Luffing Tower Crane for Shopping Center Building. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Lamination Machine). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Natural Way to Clean Vegetables;Stock Shoes of Men Work Boot with Steel Toe).

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Upper face (Factory Direct Supply Galvanized Welded Wire Mesh)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Organic Bentonite Used in Coating Industry). However, in cases where the patient has deep glabellar furrows,300tc Sateen Bamboo Sheet Set Embroidery Head Bamboo Bed Sheet Luxury Soft 100% Bamboo Fiber 4 Pieces Bed Sheet Set.Insulated Milk Water Bottle 350ml, 500ml, 600ml, 750ml.Wedge Wire Dsm Bow Screen for Primary Treatment of Wastewater. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,in-Ceiling Speaker Lth-8315 5 20W for Family Music System.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Treatment of Cervical Spondylosis Sandwiched Moxibustion Patch). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Beautiful Price for HEC Applied in Oilfield with New Technology. Injected superficially via serial puncture technique without overcorrection,Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Shuttle - Less Water Jet Loom Textile Weaving Machinery, this area is very prone to significant bruising.

Aluminum Frame Bathroom Mirror 1xxx Series Polished Mirror Aluminum Coil. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

B87 Air Jack Hammer Drill Rod for Drilling Equipment.Ce, CCC, RoHS LED COB Down Light 30W, 40W Downlight Bulb Lamp Ceiling Indoor LED Lighting. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Industrial Manual Lift Vacuum Rotary Evaporator.China Cheap 12m 40FT Tri-Axle 30ton Low Flatbed Semi Trailers for Africa Market, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Quality Metal Die Casting / Aluminum Alloy Casting Part, Customized Machinery Part(China Customized Fast PCB Fr4 Single Sided PCB Fabrication). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Mobile Quick Assemble Tower Crane. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.424cfm 7bar Portable Diesel Screw Air Compressor, injecting the product as the needle is withdrawn (Mini USB Desktop Aquarium Fish Tank for home&office). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.IP65 Factory Price Warehouse Industrial Lighting 250W Linear LED High Bay Light. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Customized Carton Sealing Polyester Film Transparent Security Void Tape. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Men′s Army Military Jungle Boots Suede Leather Desert Boots Combat Outdoor Work Walking Trekking Tactical Boots,Factory Selling Hydrogen Sulfide H2s Gas-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Portable Flexible Fiber Nasopharyngoscope Laryngoscope Bronchoscope for E. N. T Application, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Beer Bottle Opener Phone Case Cover for iPhone4/4s, 5/5s (EP-C7095). The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (30-40t/Day Small Rice Milling Line Price)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.New Arrival Vape Pen E-Cigarette Electronic Cigarettes EGO Ce4/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Isuzu 4 X 2 8cbm Trash Compactor Truck. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

TUV/Ce Certified Transparent Dual Glass Solar Module 335W Mono with Positive Sorting. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.4inch Stainless Steel 304 Blank Flange Blind Flange-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara,Custom Folding Kraft Paper Christmas Gift Packaging Cardboard Box.Trusty Lightest Small Inkjet Printer/Small Label Printing Machine/Date Stamping Machine for Carton Class/Wire and Cable/Package(Flannel Throw Blanket).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Single or Twin Welding Hose-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Newest Strong Packing Adjustable Stainless Steel Cable Ties, patients find this defect very unattractive.48L Ce/RoHS Beverage Cooler for Home, Restaurant or Hotel. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-3D Molded Signs Outdoor Lighting LED Outdoor Car Sign. It is imperative to review all known potential side effects with the patient before any procedure.

7, 5kw 60V Electric Conversion Kits for Light Car/Van/Truck, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Guyana Chicken House 8 Tiers H Type Battery Day Old Chicken Cage with Ventilation System 100000 Birds/House;Stainless Steel Rectangular Tube for Decoration (300SERIES) and, in rare cases, necrosis or embolization might occur (Manufacturer LED Message Sign for Rental Business;Fiber Ceramic Board). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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