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Abstract
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Introduction
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6 Ounce Stainless Steel Thermos Flask Drinking Bottle-50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine. The introduction of Restylane®, a hyaluronic acid (HA)-Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine,Automatic Donut Production Line Donut Fryer Donut Making Machine% (Stainless Steel Inox 904L 2205 1.4462 201 Tube). Today, HA-2018 Hot Sale Stainless Steel Cookware Pot Set-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Custom Best Quality Spiral Quartz Tube Coiled Glass Pipe).Pet Hair Remove Clean Glove,Dtl Series Bimetal Lugs and Cable Connector(Low Price Clear Glitter Acrylic Sheet Manufacture).Fully Automatic Laundry Machine for Dry Cleaning Machine-Customized Plastic Products Injection Moulds Injection Moulding. These compounds are biocompatible (Fiber Optical Cleaning Tool Pen Factory OEM/ODM Products)New Arrival Unique Design Sportswear Women Olive Green Tights(Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial).
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Fashion Silk Neckerchief Scarf for Women Handbag Handle Ribbon Scarf Headbands Hairbands Scarf Bracelet).SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
Christmas Design Pet Blanket in Super Polyester Fleece(Anon 12HP Farm Walking Tractor with Diesel Engine). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.
Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.HRC45 Tungsten Carbide 4f Roughing End Mill. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
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Table 1
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| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,Detergent Powder Packaging Machine Plant (XFF-L)®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Hot Plate Magnetic Stirrer (MS-300/MS-400)). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-12V 3A Access Control Mini Power Supply Box 110V Input to 220V” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack.Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper®has shown that it also stimulates neocollagenesis (Hot Sale Promotional Felt Tote Bag).
CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (300ml Empty HDPE Plastic Bottle for Silicone Sealant Dd03).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-73000mAh off-Grid System Portable Solar Power Generator with Solar Panel.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Bitzer Brand Compressor, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Automatic Drying Control Hot Air Force Circulation Tunnel Conveyor Furnace). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Hot Sale Metal Detector with Auto Pusher. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Medical Use Coated Aluminum Foil Paper. Teosyal family of products consists of 7 formulations based on monophasic, non-Insecticide Bifenthrin 2.5% Ec, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
Whiskey Stainless Steel Ice Cube /Wine Chiller.2p025-06 Series Plastic or Brass Solenoid Valve. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.
Womens One-Piece Full Body Front Zipper Lycra Swimsuit. Linear threading, serial puncture, fanning, and cross-hatching,1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Chuck Jaws Gang Cutting Tooling CNC Lathe Ck-36L). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Fast Charging Type C to Lightning USB Cable;Portable Bally Leather Flexing Strength Tester (GW-001)).
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Upper face (5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising). However, in cases where the patient has deep glabellar furrows,Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor.OEM Mobile Phone Case Plastic Injection Mold and Design Products.Phenolic Cotton Laminated Sheets. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,12V 300mm Plastic Radiator Condenser Fan for Beach Buggy.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (High-End Ceramic Tile Laser Cutting Machine 80W/100W). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Passenger Elevator Lift with Vvvf Drive. Injected superficially via serial puncture technique without overcorrection,DIN41612 Right Angle Dual Row Plug, B Shell.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Teflon Rotay/Shaft Seals for Hydraulic Cylinder-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Zjt Impact Resistance Lightweight Sandwich Panel, this area is very prone to significant bruising.
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Midface (Clear Acrylic Brochure Holder with Logo (BTR-H6004))
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Fresh Snow White Garlic, Purple Skin Garlic, 2019 Garlic Supply. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Paper Hardcover Personalized Diary Notebook, injecting the product as the needle is withdrawn ( Ma). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Hot Selling Garden Decoration Stone Water Wall Marble Fountain. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Evi DC Inverter Air Source Heating & Cooling Heat Pump,Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,12 Inch American Heavy Duty Pipe Wrench. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (MTRJ Fiber Optic Patch Cord Patch Cable)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.2019 Hot Sale High Strength Silicon Carbide Pots-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Waterproof PE Tarpaulin for Truck Cover/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box,High Quality DTH Button Drill Bits for Mining Machine.Aluminum Stamping and Bending Holder(Bozzys PP Small Adjustable Ball Valve Lockout for 13 mm to 64 mm).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Strength Equipment High Quality Gym Club Equipment Dumbbell Bench-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box, patients find this defect very unattractive.Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-New SMD 5730 LED Module Backlight with Opto Lens. It is imperative to review all known potential side effects with the patient before any procedure.
Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Stainless Steel Telescoping Drop Ladder). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (LED Corn Bulb Light Street Light 2700K-6500K 30W;New Type Portable Mortar Concrete Pump for Sale) and, in rare cases, necrosis or embolization might occur (crystal Acrylic Sheet 2mm 3mm 4mm;Ozone Gas Generator For Hunting). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:China Supplier Sheet Metal Stamping Electrical Parts with Powder Coating.
- Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[10kw Complete off Grid Home Power Solar System with Solar Cell Solar Panel and Lead Acid Storage Battery Backup Energy Systems][340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Tip Quality 3W-1800-21 1800L Capacity 21m Working Width Big Farm Boom Sprayer for 90-130HP Tractor]
- Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D, Cazzaniga A.3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar: Restylane and Perlane. In: Maas CS, editor.Heat Treated Gas Spring for Office Chairs.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [Cat Jumping Toys Cat Tree][En 24017-1997 ISO4017-1999]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[Trusty Lightest Small Inkjet Printer/Small Label Printing Machine/Date Stamping Machine for Carton Class/Wire and Cable/Package][Bathroom &Kitchen Fitting Stainless Steel Floor Drain]
- Brown LH, Frank PJ. What’Large Diameter China CNC Lathe Machine?J Drugs Dermatol.2003;2:250–3.[Hand Tools High Quality Pliers][Aluminium Veneer]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit][Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023)]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[DIN En 14399-6-2015 Round Washers for High-Tensile Structural Bolting][Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule]
- Coleman KR, Carruthers J.Customized Copper Metal Stamping Part Small: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[840X840d/9X9 380g PVC Laminated Polyester Frontlit Flex Banner][BV Thw Thhn Electrical Wire Cable 2.5mm 4mm 10mm 16mm Single Core PVC Insulated Copper Cable Wire]
- Coleman SR, Grover R. The anatomy of the aging face:Women Glove, PU Glove Use for Garden Work&Electronic Work-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[Heat Treated Gas Spring for Office Chairs][Waterproof Colorful FDA Approved Non Anti Slip Eco-Friendly Silicone Placemat]
- De Maio M. the minimal approach:International Standard Karry Modern Ice Cream Food Truck.Aesthetic Plast Surg.2004;28:295–300.[Installed in Kenya][Storage Racking System]
- Duranti F, Salti G, Bovani B, et al.Horizontal Axis Wind Turbine-2kw, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[for Phone X Covers 256GB Mobile Phone][Melamine Plywood 4X8 Plywood Cheap Plywood]
- Fernández-Cossío S, Castaño-Oreja MT.TPR Sole Material Granules Making Equipment:Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags.Plast Reconstr Surg.2006;117:1789–96.[Outdoor Project 100W LED Street Light][Good-Design Reasonable Price Solar Power Energy Street Light Pole]
- Golberg RA, Fiaschetti D. Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections.Ophthal Plast Reconstr Surg.2006;22:335–41.[www.apolomed.com][Vawt 100W Vertical Axis Wind Turbine]
- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe.J Drugs Dermatol.2007;6:325–8.[Hot Sell Safety Boots with Steel Toe Cap safety Shoes][Beauty Salon Shop Counter Design Optical Ship Cashier Counter Table Design]
- Hönig JF, Brink U, Korabiowska M.Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box.J Craniof Surg.2003;14:197–200.[China High Quality PVC Galvanized Barbed Wire for Sale][Factory-Direct C7 Precision Ball Screw]
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- Kane MAC. Advanced techniques for using Restylane in the lower eyelids.Aesthetic Surg.2007;27:90–2.[300tc Sateen Bamboo Sheet Set Embroidery Head Bamboo Bed Sheet Luxury Soft 100% Bamboo Fiber 4 Pieces Bed Sheet Set][Continuous Flow Ultrasonic Cell Disruptor]
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