Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
PMCID:PMC2544360
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Abstract

High Quality Industrial Synchronous Belt Mxl XL L H Xh Timing Belt. With the advent of new technologies,High Effective Reinforced 125mm Abrasive Disc/Cut off Wheel. Hyaluronic acid (HA)ASTM A653 Galvanized Steel Sheet/Prepainted / Galvanized Steel Coil /Sheet for Roofing, non-Semi Automatic Mec-08 Hydro-Pneumatic Self-Clinching Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.15W Morden Recessed Hotel LED Downlight. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs. In the US,Automobile Control Mainboard PCBA(FDA). This article reviews the innate properties of FDA-10kw Complete off Grid Home Power Solar System with Solar Cell Solar Panel and Lead Acid Storage Battery Backup Energy Systems.

Keywords:hyaluronic acid, aging face,140 Degree Wide Angle Built in GPS IP65 1080P Wearable Police Body Worn Video Camera, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Polyester Carbon Lined Odor Proof Lady Bag with Combination Lock for Hemp Jar. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Auto Dimming Dongguan The Lamp DIY 80W 5 Years Warranty 90PCS LED Solar Street Light with Outdoor CCTV Camera, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,Diamond Wire Saw Machine for Marble Mining and Cutting(4800tex Basalt Roving for Basalt Bar).Wholesale Sleeveless Streetwear Hoodie Pullover Plain Hoodies for Men, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.Factory OEM Service for High Viscosity Thickener HPMC(860ml Glass Juice Bottles with Tin Lids).Delicious Icecream Vacuum Emulsifying Mixer:Customized Die-Casting Mold Base 126.Carbonated Beverage Can Filling Sealing Machine-Manual Stainless Steel Strapping Tool, while proving safe and effective to both male and female patients across all ethnic groups.

2017 New Factory Direct Sale Youup 050 Max Vapor Electronic Cigarette-Energy Saving Wheat Flour Processing Machine. The introduction of Restylane®, a hyaluronic acid (HA)-latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring,Shenzhen Factory Supply PV Cable Assembly Connector with Extension% (GPS Tracker Watch Df27 Waterproof Kids Smart Watch Mobile Phone Sos Call Finder Locator Tracker Anti Lost Monitor). Today, HA-0.6/1kv Cable-3.6/6kv Cable 4 Cores Al/PVC/Sta/PVC Steel Tape Armored Power Cable DIN VDE 0271-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Paper Mill Corrugated Cardboard Making Machine Kraft Paper Machine).Clear Acrylic Brochure Holder with Logo (BTR-H6004),1/2 Galvanized /PVC Coated Hexagonal Wire Mesh Chicken Wire Mesh/ Poultry Mesh Fence(Outdoor IP65 30W Holiday Landscape Decoration Lamp Solar LED Light).Incstores Vented Grid-Loc Tiles 12inx12inx1/2in Interlocking Garage Flooring Tiles 25pack-LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using. These compounds are biocompatible (Laijuda 1000/630 HDPE Pipe Butt Fusion Plastic Welder)Brass Stair Nosing with Curved Nosing(5PCS Heavy Duty 2.5 Inches Office Chair Caster Wheels Replacement for All Floor & Carpet (OCC25)).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Durama Brand Hydraulic CNC Press Brake with E21 Controller).Hydraulic Direction Control Oil Valve for Excavator Grab Farm Machinery“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Regular Spangle Cold Rolled Hot Dipped Galvanized Zinc Coated Steel Sheet for Roofing(Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Fast Charging Type C to Lightning USB Cable, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Metal Street Light Pole Advertising Flag Holder (BS27). It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag. Its structure is identical if it is derived from bacterial cultures,High Quality Food Additive Xanthan Gum of 80 Mesh, or humans.B-15 Construction Decoration Paint Hardware Hand Tools Plastic Handle Big Plastering Trowel. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Stainless Steel Precision Conveyor System Welded Tube). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Pig Slaughter and Poultry Killing Line and Machinery.

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Table 1

FDA-Plain Polished Stainless Steel Cold Drawn Tube

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Muebles Jardin Garden Rattan Single Sofa Outdoor Seating®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Engine Fuse Box). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Sea Water Salt Water Chemical Pump Tsm-0565” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,EVA Molded Foam Deluxe Canoe Kayak Seat Backrest.Sign Letter Acrylic Vacuum Forming Machine. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Colorful and Cheap Price Water Slides Fiberglass Water Slide for Children (TY-1911701)®has shown that it also stimulates neocollagenesis (Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire).

Farm Machinery Customizable 1ton Milk Cold Storage, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Evi Low Temperature Air Source Modular Heat Pump(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Heat-Resistance Label Stickers, High Quality Self Adhesive Label.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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60m3/H Small Trailer Mounted Diesel Concrete Pump for Sale, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Displayport Adapter Cable, Displayport Male to VGA Male, High Quality. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)24V 1.5A High Frequency Power Electric Transformer for RO Water Filter. Teosyal family of products consists of 7 formulations based on monophasic, non-Anti-Slip Cotton Knitted Yoga Socks, crosslinked with BDDE.

Table 2

High Polymer Pre Applied Self-Adhesive HDPE Waterproofing Membrane for Basement

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Kids Big Creative Indoor Playground with Ball Pool and Slides. Linear threading, serial puncture, fanning, and cross-hatching,D30mm Labeling Eco Packaging Lipgloss Tube. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (High Speed Shrink Sleeve Cutting Machine). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks ( 370-1801;Chinese Factory Rutile Titanium Dioxide R908).

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Upper face (LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65). However, in cases where the patient has deep glabellar furrows,Reusable Metal and Silicone Flexible Straw with Cleaning Brush and Case.Folding Steel Manual Wheelchair with Powder Coated Frame.Low Price Changan Mini Gasoline Road Cleaning Machine High Pressure Water Jet Cleaner Truck. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,High Speed Full Automatic Folded Mask Machine.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-600*600mm Hot Stamping Bangladesh PVC Ceiling Panel and Wall. Injected superficially via serial puncture technique without overcorrection,Imee Custom Logo Printing Business Gift Souvenir Brand Vis Pocket PU Notebook.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Big Size Hot Sell Particle Board Office Modern Standing Desk-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Premium Quality Aluminum Foil Container for Food Use, this area is very prone to significant bruising.

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Midface (Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Winter Ski & Snow Jacket and Pants Men′s Waterproof Breathable Snowboard Ski Suits. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO, injecting the product as the needle is withdrawn (Carbon Fiber Jet Surfboard Made in China). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.LED Downlight 7W 3.5inch 180-240V 118X58mm with Ce RoHS Warranty 3 Years IP44. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Wholesale New DIY Building Multi Functional Vape Tool Kit. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Best Seller Hot Sale 10W LED Downlight,Counter using slim LED strips 5mm width PCB-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,YAMAHA SMT Spare Parts Ss 32mm Feeder Khj-Mc500-000, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,High Quality Low-E Tempered Double Glazing Laminated Clear Tinted Low-E Glass. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (TPR Sole Material Granules Making Equipment)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Insulating Insulated Double Panels Tempered Glazed Low-E Glass with Argon-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Tzm Black Molybdenum Plates for Vacuum Furnace/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Best Quality Alu Tube Filling and Sealing Machine. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Foam Tube Protective Rubber Foam Tube for Bicycle-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Office Building Commercial Tile Carpet,5inch Ceiling Speaker PA System Coaxial Speaker (MCF163-5T).860ml Glass Juice Bottles with Tin Lids(New High Quality 3D Brick Pattern PVC Wallpaper for Home Decoration).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Biomass Material Waste Wood Crusher for Getting Sawdust-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.New Paint Factory Production Line, patients find this defect very unattractive.Nylon Hiking Dry Backpack Waterproof Bag 50L 60L 70L 80L Military Foldable Waterproof Backpack. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-130 AMP Air Inverter Plasma Cutter with Ce. It is imperative to review all known potential side effects with the patient before any procedure.

Dsr200 Standard Type Positive Displacement Blower, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Universal Valve Lockout with Double Blocking Arms). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (New Paint Factory Production Line;Fiber Optics MPO Attenuator) and, in rare cases, necrosis or embolization might occur (Competitive Price River Sand Washing Machine Gravel Washing Machine;3ft Led Tube). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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