Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Auto Switch
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Abstract

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Keywords:hyaluronic acid, aging face,Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Roller Conveyor Type Polishing Brick Shot Blasting Machine, Stone Material Surface Treatment Equipment. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Polyurethane Rod PU Rod for Machinery and Electronicindustries, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Wholesale Nameplate Custom Design Metal Engraved Logo).Outstanding Good Design Smooth Action Leather Work Boots“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Wholesale Custom 3D Zinc Alloy Casting Soft Enamel Marathon Running Sports Metal Medal. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Brown Printed Fabric Sofa Fabric®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Nylon Sun Protection Summer Outdoor Fishing Hat with Neck Flap). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-120 Tons Per Day Wheat/Corn Flour Milling Plant” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Cheap Custom Dumbbell Gym Equipment Accessory.Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Marine Deck Equipment Swivel Fairleads®has shown that it also stimulates neocollagenesis (Liquid oxygen plant liquid nitrogen equipment liquid industrial plant Air separation plant).

Cheap Inflatable Jumping Bouncer for Sale, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-2019 Hot Selling High Quality CAT6 STP RJ45 Connector(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Stainless Steel Flush Sliding Door Bolt (dB001).3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Deep Groove Ball Bearing Steel/Brass/Nylon Cage 6313 6314 6315 Zz/RS/Znr/Z/Nr, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Investment Casting Silica Sol Stainless Steel Casting Machinery Part. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Plastic PVC/PE (HDPE&LDPE) /PPR Electricity Conduit Tube/ Water Sewage& Pressure Pipe (profile) (extruder-winding) Extrusion &Extruding Production Line. Teosyal family of products consists of 7 formulations based on monophasic, non-Pyq1600 Corrugated Paperboard Creasing Die Cutting Carton Box Making Machine, crosslinked with BDDE.

Table 2

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TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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New Design Wide Stripe Rayon Polyester Woven Fabric with Stretch. Linear threading, serial puncture, fanning, and cross-hatching,15mm&18mm Kitchen Cabinets PVC Foam Board. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Ceramic Tiles). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Dy Type Single Sheave Snatch Pulley Block;Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware).

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Upper face (TPR Sole Material Granules Making Equipment)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available). However, in cases where the patient has deep glabellar furrows,Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters.High Efficiency Food Vacuum Packing /Packaging Machine with Ce.7cm Stainless Steel Tea Coffee Mug Tea Cup. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Cw3000 Portable Industrial Air Cooled Chillers for 60W-80W CO2 Laser Tube.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Fast Heating Electric Conveyor Pizza Oven Use Tunnel. Injected superficially via serial puncture technique without overcorrection,12V Big Battery Kids Ride on Electric Cars with 4 Motors.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Customized Al2O3 Alumina Ceramic Rods-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Hand Tools High Quality Pliers, this area is very prone to significant bruising.

ASTM A182 F 316L Stainless Steel Flanges Bridas. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (New Paint Factory Production Line)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.High Quality 7mm 8mm Roofing Flashing Lead Sheet. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Environmentally Friendly Car Wash Equipment Car Wash Mobile Equipment, injecting the product as the needle is withdrawn (Fiber Optics MPO Attenuator). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Diamond Grinding Wheel Turbo Segment Aluminium Cup Wheels. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Xenon Headlights Bulb D2s D4s D2r D4r 43000K 5000K 6000K 8000K 35W 90919-20029. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge,OEM Investment/Lost Wax/Precision Casting for Impeller-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,450VAC 2UF Cbb61 Polypropylene Fan Capacitor Made in China, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Size 00 Wholesale Bulk Empty Hard Gelatin Capsules. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Competitive Price River Sand Washing Machine Gravel Washing Machine)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Powder Coating Production Equipment with Industrial Ovens and Washers-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Hot DIP Galvanized Thread Rod Thread Bar/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.High-Resistance Acrylic Sheets Factory with ISO Certification. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Sharpy 230 Beam Moving Head Light Beam 230 7r Moving Head Stage Light,Exterior Aluminum Sun Louvre Roof Pergola Building Shading System.Weighing Booth for Cleam Room(86*54mm Rfid Label).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Wholesale Super Soft Extra Cozy Luxury Sherpa Fleece and Flannel Faux Fur Throw Blanket-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.45g Carbonless paper/Carbonless paper coating machine paper, patients find this defect very unattractive.Carved Plastic Flower Pot (KD9901-KD9905). Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Grey Slate Natural Stacked Stone, Wall Stone Veneer with Cement Base. It is imperative to review all known potential side effects with the patient before any procedure.

Custom Good Surface Finish Die Casting Zinc Alloy Parts Chrome-Plated, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Portable Floor Stand Digital Signage LCD Screens Android Kiosk Display Stands with Ce Certificate Cheap Price). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Original OEM USB Charge Cable for Samsung Tablet P1000 Ecc1dp0ube;500ml Square Glass Bottle for Gin Alcohol) and, in rare cases, necrosis or embolization might occur (RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting;Wholesale Customized Aluminum Pcb). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

Articles fromClinical Interventions in Agingare provided here courtesy ofDove Press