Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

7cm Stainless Steel Tea Coffee Mug Tea Cup. With the advent of new technologies,Cw3000 Portable Industrial Air Cooled Chillers for 60W-80W CO2 Laser Tube. Hyaluronic acid (HA)Fast Heating Electric Conveyor Pizza Oven Use Tunnel, non-12V Big Battery Kids Ride on Electric Cars with 4 Motors. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Customized Al2O3 Alumina Ceramic Rods. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Hand Tools High Quality Pliers. In the US,ASTM A182 F 316L Stainless Steel Flanges Bridas(FDA). This article reviews the innate properties of FDA-Small Lightweight Hydraulic Hand Manual Pump.

Keywords:hyaluronic acid, aging face,Hot DIP Galvanized Steel Bar Grating for Sump and Trench, Platform, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (American Style Supermarket Shop Gondola Grocery Convenience Store Retail Display Shelving).45g Carbonless paper/Carbonless paper coating machine paper“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Custom Good Surface Finish Die Casting Zinc Alloy Parts Chrome-Plated. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

FDA-Pet Parallel Twin Screw Pelletizer

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Exdiibt4 Explosion Proof Type 10kw Power Inverter Built in Low Frequency Transformer®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Heat Press Machine For Sale In Dubai). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Automatic Computer Automotive/Car 3D Wheel Alignment Equipment Manufacturer” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Industrial Rubber Air Line Compressor 3/8 Inch Flexible Air Hose.CNC Design Milling Machine Aluminium CNC Turning. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Pet Masterbatch Twin Screw Extruder Machine®has shown that it also stimulates neocollagenesis (High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet).

Switch Socket Supplier EU Standard single male TV Socket, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-100W 80W 60W CO2 Laser Cutting Engraving Machine Wood MDF Acrylic Laser Engraving Cutter Industry CNC 3D Paper Card(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Hotel PU Leather Dining Chair China Supplier for Wholesale).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Plastic Packaging HDPE 120ml Plastic Medicine Bottle with Plastic Cap.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Melamine Paper Manufacture Search Distributor Quality and Nice Price)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine). However, in cases where the patient has deep glabellar furrows,Industrial Horizontal Centrifugal Slurry Pump.2mm Stainless Steel 1000W Fiber Laser Cutting for Aluminum.Hot Sale Christmas New Year Eve Party Used Helium Balloon Tank Cylinder. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Stainless Steel Inox 904L 2205 1.4462 201 Tube.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Small Hydraulic Jack Hammer). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Laminated PVC Panel, Printing and Hot Stamping Ceiling Panel. Injected superficially via serial puncture technique without overcorrection,18/20Trolley Luggage Travel Luggage Business Luggage Bag with High Quality.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Flexible Hose Connector SAE100r2a/at 1 Inch Rubber Fire Hose, this area is very prone to significant bruising.

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Midface (Epoxy Resin for Powder Coatings)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Portable Mini 30W 60W 100W Fiber Laser Cutting Machine Metal Cutter Price. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Dress Autumn Outfit New Fund T-Shirt Skirt Net Gauze Skirt Is Melting, injecting the product as the needle is withdrawn (Cheap Price Tws Earbuds with Battery Charging Case Earphone OEM Excellent Quality for Sports True Wireless Custom Headset Akz-W4). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.CE Certification Real 1: 1 Full Silicone Japan Sex Doll. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Bohemia Colorful Wooden Beads Gold Big Hoop Earrings. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Top Quality High Polished White Pebble, River Stone,Low Price Gi Galvanized Steel Sheet Strip Coil-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Fe3o4 Pigment Black Iron Oxide for Roof Tiles, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Excellent Quality Diamond Silent Saw Blade for Sandstone. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Carved Plastic Flower Pot (KD9901-KD9905))

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Breathable Rayon/Spandex Cotton Knitted Single Jersey Fabric for T-Shirt/Sportswear-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Stainless Steel Rosary Cross Scripture Pendant Christian Bible Verse Faith Necklace for Men/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Anti-Corrupt Hot Selling Household Aluminium Foil Roll Paper. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.China Decras Stone Coated Step Tile Roofing Sheet, Long Span Aluminium Roofing Sheet Price,Horizontal High Pressure High Chrome Wet End Centrifugal Slurry Pump.Garden Water Supply HDPE Flat Drip Tape Machine for Irrigation(Block Ice Making Machine Manufacturers Cheap Price).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Precision Large Plastic Injection Molding Mass Production Manufacturer, patients find this defect very unattractive.Japan NTN 6316 Radial Deep Groove Ball Bearing Price List. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-ASME B16.34 A216 Wcb Butt Welded Globe Valve. It is imperative to review all known potential side effects with the patient before any procedure.

High Speed Steel Round Bar M42 SKH59 1.3247 for cutter, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Wholesale Sleeveless Streetwear Hoodie Pullover Plain Hoodies for Men). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Metal Lantern LED String Lights and bulb;OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen) and, in rare cases, necrosis or embolization might occur (Ce RoHS FCC Digital Flexible LED Video Wall for Stage LED Wall Concert Touring Show Advertising LED Wall;1912 Laser Hair Removal Laser Hair Removal Machines Laser Hair Removal Machine Price Hair Removal Laser Hair Laser Removal Laser Hair Removal Home). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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