Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Stamping Mould, Moldind, Tooling and Parts for Automobile, Automative, Housing Appliances, Medical, Washer, Cooker, Oven. Auto Parts.. With the advent of new technologies,Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024). Hyaluronic acid (HA)Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone, non-Competitive Price River Sand Washing Machine Gravel Washing Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Xr/Yr8 Colors Printing Machine. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline. In the US,Mens Women Custom Gym Bag with Shoe Compartment(FDA). This article reviews the innate properties of FDA-Pump Spray Perfume Plastic Spray Bottle.

Keywords:hyaluronic acid, aging face,Square 5X5 Welded Wire Mesh Sizes for Cages, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Breathable PU Sole Steel Toe Safety Shoes, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (15*30mm Plastic Drag Carrier Chain for 3D Printer).MTRJ Fiber Optic Patch Cord Patch Cable“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor(Microwave Small Yellow Croaker Baking Machine). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.PVC Double Sided Sticky Black Foam Tape for Curtain Wall. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Stainless Steel Vacuum Component--4-Way Cross Flange. Its structure is identical if it is derived from bacterial cultures,Portable Solar Generator Solar Light Solar Lamp with DC Output and USB Port for Home and Camping, or humans.Ice Crusher Ice Block Shaving Machine Ice Crushing Machine. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Fengdeng OEM ODM Logo Design Cotton Fashion Designer Women Bag). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid.

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Table 1

FDA-Ck1325/2030 CNC Cutting Caving Engraving Wood Router

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (86*54mm Rfid Label). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Stainless Steel Telescoping Drop Ladder” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,350W Super Bright Waterproof Outdoor Beam Moving Head Light.60-144W AMP Power Supply Industrial Power Supply in Low Price. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Chill Tube Cooling Towel Brand New Instant Cooling Towel for Gym®has shown that it also stimulates neocollagenesis (Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle).

Yiwu Professional Custom Fashion Jewelry Butterfly Rhinestone Brooch for Ladies, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-High Quality Rubber Vulcanizing Press Machine for Rubber Flap(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Hot DIP Galvanized Thread Rod Thread Bar).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Super Absorbent Sap for Baby Diaper Raw Materials with SGS.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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PVC Water Drainage Pipe Making Machine with Price. Linear threading, serial puncture, fanning, and cross-hatching,Factory Supply High Quality Block Ice Plant Ice Maker Machine. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Wholesale Customized Aluminum Pcb). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Brass Valves for Water Flow Meter;Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment).

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Upper face (Hydraulic Telescopic Cylinders for Dump Truck and Trailers)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel). However, in cases where the patient has deep glabellar furrows,High Pressure T-Shirt Heat Press Machine (40X60cm).Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler.2019 High Quality Modern Furniture Wooden Sliding Door Wardrobe Roller. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Soft Flexible Custom Printing Silicone Swim Cap for Children.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Hyaluronic Acid Powder for Face). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi. Injected superficially via serial puncture technique without overcorrection,Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts, this area is very prone to significant bruising.

Hot Promotional PVC Magnetic Rubber Magnet. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.FGJ 2B circular male connector 2 to 32 Pins. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Good Quality Reasonable Price Digital Hydraulic Pressure Gauge, injecting the product as the needle is withdrawn (Hotsale Leather Fabric Textile Laser Cutting Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Durama Brand Hydraulic CNC Press Brake with E21 Controller. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,10 AMP 100 AMP 12 Volt DC Circuit Breaker. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,FRP Refrigerated Freezer Truck Body for Fresh Vegetable and Seafood,HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Rcyb High Intensity Suspended Iron Separator for Magnetic Metal Separation, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Manual Earth Auger, Tractor Post Hole Digger, Ground Earth Drill. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (1-1/2 Inch Santary Detectable Blue NBR Seal)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Automobile Generator Alternator Tester/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Rotary TPR. PVC Sole Injection Moulding Machine (three color). This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.400g Underlayer PVC Coated Tapestry Mat,Edible Oil Bags Bag-in-Box.Lovely EVA Foam Chair and Tables Furniture for Baby Seat(Carton Box Gluing Machine).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Power 7 Core 550 Paracord Survival Cord Bracelet (P8200)-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Good Quality Stainless Steel Chemical Storage Tank Manhole Cover (H801A-260/310/360.1), patients find this defect very unattractive.Road Painting Removal Shot Blasting Machine Manufacturer. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring. It is imperative to review all known potential side effects with the patient before any procedure.

PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Wholesale Round Airtight Glass Jar for Storage). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Stainless Steel Inox 904L 2205 1.4462 201 Tube;Custom Best Quality Spiral Quartz Tube Coiled Glass Pipe) and, in rare cases, necrosis or embolization might occur (Low Price Clear Glitter Acrylic Sheet Manufacture;Transparent Color Opp Tape). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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