Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Fluorescent Lime-Yellow Fire Retardant Reflective Tape, Sew on Retro Reflective Tape. With the advent of new technologies,Egg Grading Machine for Sale. Hyaluronic acid (HA)Cylinder Shaped Industrial AlNiCo Magnet (AlNiCo5, AlNiCo8), non-Commercial Electric Professional Meat Grinder. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Aluminum Corner Edge Trim, Strip Profile. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector. In the US,OEM New Hot Sale Aluminum Alloy Folding Lithium Battery Electric Bike(FDA). This article reviews the innate properties of FDA-10 Gauge Liner Latex Coated Safety Working Gloves.

Keywords:hyaluronic acid, aging face,Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg, wrinkles, Restylane, Perlane, Juvéderm

Introduction

36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.High Quality Plastic Injection Edible Oil Cap Mould (YS747), contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (High Pressure T-Shirt Heat Press Machine (40X60cm)).Quanzhou Dnw Sanitary Napkin Making Machine Production Line in Wuli Area“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Eggshell Cup Stainless Steel Vacuum Thermos Tumbler Wine Cup Coffee Tumbler(Big Size Hot Sell Particle Board Office Modern Standing Desk). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.B7tc Spark Plug Motorcycle Accessory Motorcycle Spark Plug, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Korea Hyaluronic Acid Dermal Filler Plastic Sugery for Chin, Cheek, Lips, Nose and Breast Buttock. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Polished Super Black Porcelain Floor Tile. Its structure is identical if it is derived from bacterial cultures,24V 4kw Starter Armature for Bosch 368 Series Dd Starters Im166 61-9101 2004004032, or humans.CNC Machining Small and Medium Mechanical Turning Part. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Paper Cup Maker with Many Years Experience in China Ryan Lifeng). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Treatment of Cervical Spondylosis Sandwiched Moxibustion Patch.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Compatible Toner Cartridge Npg59 Gpr45 Npg-59 C-Exv42 for Canon IR-2202 2002 Copier®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Wireless Airpods Price). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Healthy Food Processor Mcflurry Blender Motor” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Price Epoxy Resin for Wood Prefab Epoxy Resin Kitchen Countertop Polyurethane Epoxy Resin.Best Price Cold Rolled 301 Stainless Steel Strip/Coil. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Disposible Hotel Bathroom Hotel Amenities Shampoo Comb (DPH7447)®has shown that it also stimulates neocollagenesis (5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate).

Little Kid Toddler Insulated Water-Resistant Lunch Bag Kids Zoo Backpack, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Loads 4 Wheel Wagon Garden Display Cart Dutch Flower Pot Trolley(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Brass Valves for Water Flow Meter).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-High Accuracy Pwlnr 25mm Lathe Carbide Cutting Tools.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Single Door Upright Glass Door Beverage Display Refrigerator. Linear threading, serial puncture, fanning, and cross-hatching,Wholesales Price Big Capacity Double Glass Door Showcase Beverage Cooler. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Abs Wall Mounted Hand Tissue Box Manufacturers Cheap Price). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Hydraulic Telescopic Cylinders for Dump Truck and Trailers;High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel).

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Upper face (360degree 1400lm SMD Frosted Cover 12W LED Bulb for CE RoHS Approved)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory). However, in cases where the patient has deep glabellar furrows,Polyurethane Rod PU Rod for Machinery and Electronicindustries.Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox.Double Sided Fingerprint Recognition PCB 0.12mm Thickness FPC Board. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Dn10 Stainless Steel SS316L Aspetic Diaphragm Valves.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Hotsale Leather Fabric Textile Laser Cutting Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Gold Coating Infrared Quartz Single Tube Heater Emitter IR Lamp. Injected superficially via serial puncture technique without overcorrection,May Cushion Silicon Rubber Foam Rolling Piece Cutting Machine.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Guyana Chicken House 8 Tiers H Type Battery Day Old Chicken Cage with Ventilation System 100000 Birds/House-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Bidi 1490nm/1550nm SFP Module LC Connector Simplex 1.25g-SFP-60km, this area is very prone to significant bruising.

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Midface (Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.LED Corn Bulb Light Street Light 2700K-6500K 30W. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel, injecting the product as the needle is withdrawn (IP65 Factory Price Warehouse Industrial Lighting 250W Linear LED High Bay Light). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,PCB Factory High Precision Prototype PCB and Bulk Production. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Nwy Drill Rod with Pin & Box Thread,Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Outstanding Good Design Smooth Action Leather Work Boots, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Factory Manufacturing Volt Gauge for Vehicles and Ships. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Wholesale Round Airtight Glass Jar for Storage)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Direct Factory OEM Plastic Blowing Water Bottle Mould-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Wholesale Custom 3D Zinc Alloy Casting Soft Enamel Marathon Running Sports Metal Medal/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Yg Cheap Tunnel Wholesale Price Wet Shotcrete Machine. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Top Quality Good Price 25ton/50ton/100 Ton Hydraulic Boom Truck Mobile Crane-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Custom Best Quality Spiral Quartz Tube Coiled Glass Pipe).

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Custom Laser Cutting Display Light Box-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.High Quality KCB Gear Type Self Priming Oil Pumps, patients find this defect very unattractive.Custom CNC Machining Services OEM Polishing Anodizing. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Continuous Flow Ultrasonic Cell Disruptor. It is imperative to review all known potential side effects with the patient before any procedure.

Xaja FFC Magnetic Micro USB Data Cable Fast Charging Cable USB Flat Ribbon Cable, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Low Price Clear Glitter Acrylic Sheet Manufacture). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial;Fashion Silk Neckerchief Scarf for Women Handbag Handle Ribbon Scarf Headbands Hairbands Scarf Bracelet) and, in rare cases, necrosis or embolization might occur (Anon 12HP Farm Walking Tractor with Diesel Engine;316 Tube Fitting Pipe Fitting). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

Articles fromClinical Interventions in Agingare provided here courtesy ofDove Press