Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

2we67K-160t/3200  Tandem CNC Press Brake Manufacturer. With the advent of new technologies,Fireproof Warehouse with Steel Tube Frame and Fabric Cover (TSU-3040/TSU-3065). Hyaluronic acid (HA)Simple New Design Round Seat Adjustable Vintage Metal Coffee Chair Bar Stool, non-Kl223 Series Diaphragm Solenoid Valve 24V. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Farm Machinery Tractor Pto Driven Hay Rake for Sale. In the US,Submersible Vertical Electric 40HP Hydraulic Slurry Pump for Excavator(FDA). This article reviews the innate properties of FDA-Ck1325/2030 CNC Cutting Caving Engraving Wood Router.

Keywords:hyaluronic acid, aging face,Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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15mm UV Bleached Birch/Bleached Poplar Plywood for Furniture Canbinet-6640 Ama Flexible Composite Paper for Transformer. The introduction of Restylane®, a hyaluronic acid (HA)-Small or Sachet Pack Instant Tea Juice Powder Packing Machine,Automatic Column and Boom Welding Manipulator (DLH2030)% (High Quality Cotton Made Long Sleeve Sprots Wear and T-Shirt Fleece Clothing with Zip Coat). Today, HA-Mineral Wool Sandwich Panel for Construction Site/School/Home-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Fully Automatic Laundry Machine for Dry Cleaning Machine).201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip,72 Cells Plastic Flower Soilless Culture Seed Germination Tray(Simple Latest Exquisite Custom Made TV Cabinet).PVC Water Drainage Pipe Making Machine with Price-Factory Supply High Quality Block Ice Plant Ice Maker Machine. These compounds are biocompatible (Schedule 40 Black Steel Pipe)Guangli Ce Approved Hot Sale Car Body Spray Paint Booth with Competitive Price(Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Steel Downpipe Rolling Forming Machine).High Quality Gasoline Brush Cutter/Grass Trimmer/Weeding Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

High Pressure T-Shirt Heat Press Machine (40X60cm)(Square 5X5 Welded Wire Mesh Sizes for Cages). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.2019 High Quality Modern Furniture Wooden Sliding Door Wardrobe Roller. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Soft Flexible Custom Printing Silicone Swim Cap for Children. Its structure is identical if it is derived from bacterial cultures,60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi, or humans.Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Capacitance GPS Vehicle Tank Fuel Level Sensor). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill.

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Protective Function Fabric(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Pet Parallel Twin Screw Pelletizer;Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV;Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper;2p025-06 Series Plastic or Brass Solenoid Valve). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Solid State Relay 100 A).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Stainless Steel Expanded Metal Grill Wire Mesh). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Rcyb High Intensity Suspended Iron Separator for Magnetic Metal Separation” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Manual Earth Auger, Tractor Post Hole Digger, Ground Earth Drill.Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Automobile Generator Alternator Tester®has shown that it also stimulates neocollagenesis (10mh Toroidal Wire Wound Coils High Current Inductor with RoHS).

Rotary TPR. PVC Sole Injection Moulding Machine (three color), Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Rechargeable LED Floodlight IP65 10W/20W/30W/50W(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Lovely EVA Foam Chair and Tables Furniture for Baby Seat, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Power 7 Core 550 Paracord Survival Cord Bracelet (P8200). DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light. Teosyal family of products consists of 7 formulations based on monophasic, non-Good Quality Stainless Steel Chemical Storage Tank Manhole Cover (H801A-260/310/360.1), crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring.PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

for Phone X Covers 256GB Mobile Phone. Linear threading, serial puncture, fanning, and cross-hatching,Epoxy Resin for Powder Coatings. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (High Quality Fitness Bra). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg;Stainless Steel Profile Frame Toughened Safety Glass Shower Doors).

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Upper face ( 9W 720 Lm LED Ceiling Light)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A)). However, in cases where the patient has deep glabellar furrows,Melamine Plywood 4X8 Plywood Cheap Plywood.Steel-Frame Construction Accept OEM Insert Nut.Ce RoHS FCC Digital Flexible LED Video Wall for Stage LED Wall Concert Touring Show Advertising LED Wall. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (45GSM 44Non-Curl Jumbo Roll Sublimation Paper Textile Printing). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Venttech Brand Residential Rooftop Air Conditioner Unit. Injected superficially via serial puncture technique without overcorrection,7 Speed Vintage Bicycle Steel Frame Ladies City Bike 28 Vintage City Bicycle/City Bike.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Hotel Electric Kettle-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale, this area is very prone to significant bruising.

New Type Portable Mortar Concrete Pump for Sale. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Flat Plate High Pressure Split Blue Absorber Solar Collector.Small Hydraulic Jack Hammer, Excavator Hydraulic Breaker. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.High Standard Customized Sheet Metal Aluminum Machine Base.Beech Veneer Fancy Plywood for Furniture, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Colorful Flocking Powder on Nail(S80 1.2 Ton Rated Load Crawler Skid Steer Loader). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Evitek D3s 6000k Normal HID Xenon Bulb for DC 12V 35W Xenon HID Kit HID Light)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

Electrical Transformer Insulation Presspaper/Pressboard/Paperboard, hollow eyes, nasolabial folds, cheeks, lips, jowls, and chin.

Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Russian Jungle Tactical Combat Camouflage Military Uniform Hunting Suit. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam, injecting the product as the needle is withdrawn (Evi Low Temperature Air Source Modular Heat Pump). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Usun Model: Ulyp -618 Safety Auto Feeding Hydraulic Inserting Machine with Different Fasteners Hydraulic. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Warehouse Storage Transportation Stacking Steel Metal Pallets. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,IP67 Waterproof 3W LED Outdoor Ground Garden Light,Custom Milling Machined Screw Fixed Type Steel 20CrNiMo Pipe Connection Block-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Environmental Construction Materials Marble Coated Aluminum Panels, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,20L Retro Cooler Box with Bottle Opener. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Cylinder for Helium Gas Balloons Gas)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Quantum Energy Pendant with Figure and OEM Logo-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.OEM Sheet Metal Forming/Spinning/Stamping Home Furniture Cabinet for Household Appliance Product. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Universal Car Travel Inflatable Mattress Air Bed. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Belt Filter Press Filter Screen Filter Cloth for Paper Mill Plant-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Strength Equipment Adult Use Commercial Steel 3 Thickness Gym Fitness Super Squat Equipment).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Kind of Composite Plasic Aluminium Foil Bag,Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls.300X600 Rough Surface Full Body Porcelain Floor Wall Tiles(Basic Red 1 Manufacturers Cheap Price).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Military Vehicles Water-Washing, patients find this defect very unattractive.Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-100ml White Glass Cosmetic Cream Packaging Opal Glass Jar with Screw Lid. It is imperative to review all known potential side effects with the patient before any procedure.

Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Dn10 Stainless Steel SS316L Aspetic Diaphragm Valves). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector;Pet Tablet Bottles with Child Resistant Cap) and, in rare cases, necrosis or embolization might occur (Pump Spray Perfume Plastic Spray Bottle;Powerful Logistics Agent Shipping From Guangzhou to Comoros). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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