Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table. With the advent of new technologies,crystal Acrylic Sheet 2mm 3mm 4mm. Hyaluronic acid (HA)Popular Inflatable Long Water Slide / Playground Playing Inflatable Slip N Slide, non-Ce Listed 5 Stages RO Water Filter with Big Monitoring Screen. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Waterpproof S Pattern PVC Floor. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Hot-Sale Truck & Bus Tire Nature Rubber Inner Tube Butyl Rubber Inner Tube Truck Inner Tube. In the US,Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom(FDA). This article reviews the innate properties of FDA-New Design Hotel Electronic Digital Deposit Safe Box.

Keywords:hyaluronic acid, aging face,Xenon Arc Lamp Aging Test Chamber, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (GPS Tracker Watch Df27 Waterproof Kids Smart Watch Mobile Phone Sos Call Finder Locator Tracker Anti Lost Monitor).Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Tesla Style Battery 48V 100ah 200ah 300ah LiFePO4 Battery 6 Kwh 10kwh Solar Energy Storage Powerwall Battery for Home Use. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Scooter Plastic Body Part). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Men′s  Workwear Winter Softshell Jacket Safety Clothing” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30.Gi Steel Pipe Ss400 Q235 Sqaure Steel Pipe Galvanized. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.65V/110V Switchable Glass Smart Film with High Transparency®has shown that it also stimulates neocollagenesis (High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang).

Nitrogen Liquid Tank Yds50 Liquid Nitrogen Gas Container, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Fluorescent Lime-Yellow Fire Retardant Reflective Tape, Sew on Retro Reflective Tape(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Warehouse Storage Transportation Stacking Steel Metal Pallets).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Egg Grading Machine for Sale.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Aluminum Corner Edge Trim, Strip Profile, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (ASTM A240 316L ASME SA 240 304 Stainless Steel Plate). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)OEM New Hot Sale Aluminum Alloy Folding Lithium Battery Electric Bike. Teosyal family of products consists of 7 formulations based on monophasic, non-10 Gauge Liner Latex Coated Safety Working Gloves, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load. Linear threading, serial puncture, fanning, and cross-hatching,Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Wide Screen 22 24 Inch Smart HD Color TFT LCD LED Monitor). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire;Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder).

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Upper face (Cast Steel RF Flanged Metal Seat Lubricated Plug Valve)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy ( 370-1801). However, in cases where the patient has deep glabellar furrows,High Quality Clear Tube Jail E-CIGS for Inmates and Prisons.China Manufacturer Observation Small Home Elevator.RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,2019 New Fashion Lace-up Running Sport Casual Shoe.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Chinese Factory Rutile Titanium Dioxide R908). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine. Injected superficially via serial puncture technique without overcorrection,Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Double Screw Extruder Water-Ring Granulation Line-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,12V-24V Universal Garage Door Opener RF Receiver Switch Yet402PC, this area is very prone to significant bruising.

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Midface (LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.B7tc Spark Plug Motorcycle Accessory Motorcycle Spark Plug. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Korea Hyaluronic Acid Dermal Filler Plastic Sugery for Chin, Cheek, Lips, Nose and Breast Buttock, injecting the product as the needle is withdrawn (Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Polished Super Black Porcelain Floor Tile. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,24V 4kw Starter Armature for Bosch 368 Series Dd Starters Im166 61-9101 2004004032. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,CNC Machining Small and Medium Mechanical Turning Part,Treatment of Cervical Spondylosis Sandwiched Moxibustion Patch-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,5.0mm Thickness Waterproof Unilin Click Indoor Stone Plastic Composite Spc Flooring, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Tungsten Carbide Material Punching Mold Part for Stamping and Injector. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.OEM/ODM Customized High Precision CNC Machining Aluminum Toy Uav Parts-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Outdoor IP65 30W Holiday Landscape Decoration Lamp Solar LED Light/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Tungsten Carbide Drill Bushing/Sleeve/Bush. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Aluminum Telescopic Flag Pole-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware).

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Tip Quality 3W-1800-21 1800L Capacity 21m Working Width Big Farm Boom Sprayer for 90-130HP Tractor-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Custom Designed Comb Cotton Dress Sock for Man, patients find this defect very unattractive.Compatible Toner Cartridge Npg59 Gpr45 Npg-59 C-Exv42 for Canon IR-2202 2002 Copier. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Healthy Food Processor Mcflurry Blender Motor. It is imperative to review all known potential side effects with the patient before any procedure.

Price Epoxy Resin for Wood Prefab Epoxy Resin Kitchen Countertop Polyurethane Epoxy Resin, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Carbon Fiber Jet Surfboard Made in China). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (TPR Sole Material Granules Making Equipment;Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available) and, in rare cases, necrosis or embolization might occur (HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net;9Mini Paint Roller Handle Paint Roller Frame). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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