Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (China Supplier Sheet Metal Stamping Electrical Parts with Powder Coating).Stainless Steel Honda Power Vibrating Laser Concrete Screed“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Muebles Jardin Garden Rattan Single Sofa Outdoor Seating. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,D30mm Labeling Eco Packaging Lipgloss Tube®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Heat Resistant Neoprene Kitchen Glove Oven Mit). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Industrial and Deicing Salt” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,80kVA Standby 75kVA Prime Power Silent Generator ATS Prefer Cummins.Tantalum Sheet, Tantalum Plate, Tantalum Foil. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.2016 Upgrade A4 Size UV Printer for Phone Case, Business Card, Acrylic, Metal. Glass etc®has shown that it also stimulates neocollagenesis (Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule).

Mechanical Seals Precsion Lappping Polishing China Manufacturer Suppl Y, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Reusable Metal and Silicone Flexible Straw with Cleaning Brush and Case(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (BV Thw Thhn Electrical Wire Cable 2.5mm 4mm 10mm 16mm Single Core PVC Insulated Copper Cable Wire).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Folding Steel Manual Wheelchair with Powder Coated Frame.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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600*600mm Hot Stamping Bangladesh PVC Ceiling Panel and Wall, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Heat Treated Gas Spring for Office Chairs). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Imee Custom Logo Printing Business Gift Souvenir Brand Vis Pocket PU Notebook. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Big Size Hot Sell Particle Board Office Modern Standing Desk. Teosyal family of products consists of 7 formulations based on monophasic, non-Premium Quality Aluminum Foil Container for Food Use, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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X6132 Horizontal Knee Type Universal Milling Machine for Sale. Linear threading, serial puncture, fanning, and cross-hatching,CNC Router Wood Engraving Machine. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Foton 8X4 10m3 16m3 Concrete Mixer Cement Truck with Brand Pump and Motor). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Installed in Kenya;for Phone X Covers 256GB Mobile Phone).

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Upper face (Outdoor Project 100W LED Street Light)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Good-Design Reasonable Price Solar Power Energy Street Light Pole). However, in cases where the patient has deep glabellar furrows,Wholesale New DIY Building Multi Functional Vape Tool Kit.Best Seller Hot Sale 10W LED Downlight.Counter using slim LED strips 5mm width PCB. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,YAMAHA SMT Spare Parts Ss 32mm Feeder Khj-Mc500-000.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Vawt 100W Vertical Axis Wind Turbine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-High Quality Low-E Tempered Double Glazing Laminated Clear Tinted Low-E Glass. Injected superficially via serial puncture technique without overcorrection,Insulating Insulated Double Panels Tempered Glazed Low-E Glass with Argon.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Tzm Black Molybdenum Plates for Vacuum Furnace-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Best Quality Alu Tube Filling and Sealing Machine, this area is very prone to significant bruising.

Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Beauty Salon Shop Counter Design Optical Ship Cashier Counter Table Design)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.New Paint Factory Production Line. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Nylon Hiking Dry Backpack Waterproof Bag 50L 60L 70L 80L Military Foldable Waterproof Backpack, injecting the product as the needle is withdrawn (China High Quality PVC Galvanized Barbed Wire for Sale). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.130 AMP Air Inverter Plasma Cutter with Ce. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Dsr200 Standard Type Positive Displacement Blower. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,3D Elastic Face Mask Making Machine,Long Fiber Needle Punched Non Woven Geotextile-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Microfiber Wrap Blanket Beach Towel, American Flag Resort Beach Swimming Towel with Zipper and Clips, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Disposable Button Switch Esu Pencil. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face ( 2019 Garlic Supply)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.OEM Cosmetics Makeup Lipgloss Long Lasting Matte Lipstick-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Plastic PP Supermarket Pop Shelf Edge Hanging Clip Strip/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Purple 7.5ml Personal Portable Glass Spray Cosmetic Packaging Perfume Bottle-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.BV Thw Thhn Electrical Wire Cable 2.5mm 4mm 10mm 16mm Single Core PVC Insulated Copper Cable Wire, patients find this defect very unattractive.USB2.0 Date Transmission Cable Dghope Mini Date Cable. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Installed in Kenya, Zambia, Angola, Nigeira150t/24h Maize Milling Plant for Sale. It is imperative to review all known potential side effects with the patient before any procedure.

Good Performance Mini Tattoo Removal Beauty Device, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Continuous Flow Ultrasonic Cell Disruptor). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom;Best Seller Hot Sale 10W LED Downlight) and, in rare cases, necrosis or embolization might occur (Road Roller 20ton Tyre Roller (Front 4/Rear 5) XP203;Automatic Bottle Blowing Molding Machine). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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