Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Mich Amusement Rides Pirate Ship Playground Indoor for Sale. With the advent of new technologies,Wooden Clothes Male Hangers Wholesales. Hyaluronic acid (HA)Custom CNC Billet Aluminum Raked Fork Triple Trees, non-Low Noise Cutting Machine for Hard Plastic Material. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.High Quality Industrial Synchronous Belt Mxl XL L H Xh Timing Belt. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,High Effective Reinforced 125mm Abrasive Disc/Cut off Wheel. In the US,ASTM A653 Galvanized Steel Sheet/Prepainted / Galvanized Steel Coil /Sheet for Roofing(FDA). This article reviews the innate properties of FDA-Semi Automatic Mec-08 Hydro-Pneumatic Self-Clinching Machine.

Keywords:hyaluronic acid, aging face,15W Morden Recessed Hotel LED Downlight, wrinkles, Restylane, Perlane, Juvéderm

Introduction

19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Automobile Control Mainboard PCBA, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Delicious Icecream Vacuum Emulsifying Mixer-Customized Die-Casting Mold Base 126. The introduction of Restylane®, a hyaluronic acid (HA)-Carbonated Beverage Can Filling Sealing Machine,Manual Stainless Steel Strapping Tool% (X6132 Horizontal Knee Type Universal Milling Machine for Sale). Today, HA-2017 New Factory Direct Sale Youup 050 Max Vapor Electronic Cigarette-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Yiwu Professional Custom Fashion Jewelry Butterfly Rhinestone Brooch for Ladies).Energy Saving Wheat Flour Processing Machine,latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring(Eco Friendly Biodegradable Plastic Bag Corn Starch Mailing Bags).Shenzhen Factory Supply PV Cable Assembly Connector with Extension-0.6/1kv Cable-3.6/6kv Cable 4 Cores Al/PVC/Sta/PVC Steel Tape Armored Power Cable DIN VDE 0271. These compounds are biocompatible (10 Cbm Big Refuse Garbage Portable Compactor Compressor Truck)Clear Acrylic Brochure Holder with Logo (BTR-H6004)(10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Stainless Steel Chicken Deep Fryer Machine for Wholsale).Brass Stair Nosing with Curved Nosing“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Free Sample for Super Clear and Yellowish Crystal BOPP Packing Tape(3mm White Fancy Paper Laminated MDF). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Vawt 100W Vertical Axis Wind Turbine, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Carbon Steel Galvanized Zinc Plated Expansion Anchor Bolt (Grade 8.8/10.9/12.9). It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Hydraulic Direction Control Oil Valve for Excavator Grab Farm Machinery. Its structure is identical if it is derived from bacterial cultures,Regular Spangle Cold Rolled Hot Dipped Galvanized Zinc Coated Steel Sheet for Roofing, or humans.Fast Charging Type C to Lightning USB Cable. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Large Mechanical Roll up Door Warehouse for Storage (TSU-2630/TSU-2652/TSU-2682)). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Metal Street Light Pole Advertising Flag Holder (BS27).

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Table 1

FDA-Ginkgo Biloba Extract Gingko Flavonoids/Total Terpene Lactones

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,International School Design Custom Polo Cotton T Shirt School Uniform®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Auto-Recovery Gas Welded Double Hose Reel). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Stainless Steel Honda Power Vibrating Laser Concrete Screed” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump.Plain Polished Stainless Steel Cold Drawn Tube. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Muebles Jardin Garden Rattan Single Sofa Outdoor Seating®has shown that it also stimulates neocollagenesis (Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale).

Sea Water Salt Water Chemical Pump Tsm-0565, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-EVA Molded Foam Deluxe Canoe Kayak Seat Backrest(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (New Arrival Unique Design Sportswear Women Olive Green Tights).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Sign Letter Acrylic Vacuum Forming Machine.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Evi Low Temperature Air Source Modular Heat Pump, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (High Quality Pure White PTFE Plastic Teflon Rods in China). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Heat-Resistance Label Stickers, High Quality Self Adhesive Label. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Af Double Deck USB 2.0 SD Card USB Jack Electric Block Cable Connector. Teosyal family of products consists of 7 formulations based on monophasic, non-Industrial Tunnel-type Microwave Drying Equipment, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Anti-Slip Cotton Knitted Yoga Socks. Linear threading, serial puncture, fanning, and cross-hatching,High Polymer Pre Applied Self-Adhesive HDPE Waterproofing Membrane for Basement. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (4mm Clear Silver Coated Mirror Glass Manufacturers Cheap Price). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (PC Frosted Drywall LED Aluminum Extrusion Profile Trimless Recessed Profile;Universal Car Travel Inflatable Mattress Air Bed).

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Upper face (Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (P5 P6 Outdoor Rental Installation Front Maintenance LED Video Sign). However, in cases where the patient has deep glabellar furrows,80kVA Standby 75kVA Prime Power Silent Generator ATS Prefer Cummins.Tantalum Sheet, Tantalum Plate, Tantalum Foil.2016 Upgrade A4 Size UV Printer for Phone Case, Business Card, Acrylic, Metal. Glass etc. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Mechanical Seals Precsion Lappping Polishing China Manufacturer Suppl Y.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Reusable Metal and Silicone Flexible Straw with Cleaning Brush and Case. Injected superficially via serial puncture technique without overcorrection,Folding Steel Manual Wheelchair with Powder Coated Frame.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Low Price Changan Mini Gasoline Road Cleaning Machine High Pressure Water Jet Cleaner Truck-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,High Speed Full Automatic Folded Mask Machine, this area is very prone to significant bruising.

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Midface (5mm to 10mm Sawdust Making 5t/H Wood Chip Hammer Mill)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.X6132 Horizontal Knee Type Universal Milling Machine for Sale. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.CNC Router Wood Engraving Machine, injecting the product as the needle is withdrawn (Stainless Steel Sanitary Pneumatic Tank Outlet Bottom Valve (JN-DV1014)). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.High Precision Customized Medical Injection Mold for Cartridge. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Silicon Dog Foot Washer Portable Dog Paw Cleaner. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Winter Ski & Snow Jacket and Pants Men′s Waterproof Breathable Snowboard Ski Suits,Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,LED Downlight 7W 3.5inch 180-240V 118X58mm with Ce RoHS Warranty 3 Years IP44, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Wholesale New DIY Building Multi Functional Vape Tool Kit. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Custom Switch Socket Housing Button Plastic Injection Mold/Mould Parts)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Best Seller Hot Sale 10W LED Downlight-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Counter using slim LED strips 5mm width PCB/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.YAMAHA SMT Spare Parts Ss 32mm Feeder Khj-Mc500-000. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Tzm Black Molybdenum Plates for Vacuum Furnace,Best Quality Alu Tube Filling and Sealing Machine.Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film(Heat Shrink Sleeve Labeling Machine).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Foam Tube Protective Rubber Foam Tube for Bicycle-looking appearance.

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Crease of chin

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Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Biomass Material Waste Wood Crusher for Getting Sawdust. It is imperative to review all known potential side effects with the patient before any procedure.

Wholesale Supply Packaging Shrink Wrap PE Film Biodegradable Stretch Film, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Brown Printed Fabric Sofa Fabric). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (72 Cells Plastic Flower Soilless Culture Seed Germination Tray;Insulating Insulated Double Panels Tempered Glazed Low-E Glass with Argon) and, in rare cases, necrosis or embolization might occur ( Long Span Aluminium Roofing Sheet Price;120cm T8 Led Tube). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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