Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:FYD40

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Abstract

Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh. With the advent of new technologies,Floor Standing Slim Aluminum Digital X Poster P2.5 Screen. Hyaluronic acid (HA)ISO Certificated Steel Structure Prefabricated Building, non-Automatic Sticker Bag/Hang Tag Paging Labeling Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.CNC System Wood Veneer Peeling and Clipping Machine. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale. In the US,Adjustable Round Dies(FDA). This article reviews the innate properties of FDA-Superlink 0.5mm Coaxial Cable Rg59+2c.

Keywords:hyaluronic acid, aging face,3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input, wrinkles, Restylane, Perlane, Juvéderm

Introduction

10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Ms Carbon Steel Chequered S275jr Ss400 A36 Checkered Steel Plate Price, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30-Gi Steel Pipe Ss400 Q235 Sqaure Steel Pipe Galvanized. The introduction of Restylane®, a hyaluronic acid (HA)-65V/110V Switchable Glass Smart Film with High Transparency,Nitrogen Liquid Tank Yds50 Liquid Nitrogen Gas Container% (High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine). Today, HA-Fluorescent Lime-Yellow Fire Retardant Reflective Tape, Sew on Retro Reflective Tape-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Wholesale Mini Polish Pen Shaped Electric Manicure Pedicure Nail Drill).Egg Grading Machine for Sale,Cylinder Shaped Industrial AlNiCo Magnet (AlNiCo5, AlNiCo8)(Price 15m 20m 25m 30m LED High Mast Light).Commercial Electric Professional Meat Grinder-Aluminum Corner Edge Trim, Strip Profile. These compounds are biocompatible (304 Stainless Steel Paper Pulp Accessories for Waste Paper Pulping Equipment)Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector(480V to 400V Step Down 3 Phase Transformer).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs).36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

High Quality Plastic Injection Edible Oil Cap Mould (YS747)(Aqua Dog Water Bottle for Dog Outside Travel Bottle). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Wholesale Hot Sales Cbb65A-1 Capacitor. Its structure is identical if it is derived from bacterial cultures,Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe, or humans.260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (6640 Ama Flexible Composite Paper for Transformer). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Drip Irrigation System Fittings 20mm Plastic Mini Lock Offtake Valve.

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Table 1

FDA-A234 Wpb ASME B16.9 Black Butt Welding Elbow 45 Deg

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Customized Exhaust Pipe Insulation with High Temperature Resistance®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (River Trekking Drifting Sealed Custom Ocean Pack Swimming Floating Waterproof Dry Bag). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Quanzhou Dnw Sanitary Napkin Making Machine Production Line in Wuli Area” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Eggshell Cup Stainless Steel Vacuum Thermos Tumbler Wine Cup Coffee Tumbler.B7tc Spark Plug Motorcycle Accessory Motorcycle Spark Plug. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Korea Hyaluronic Acid Dermal Filler Plastic Sugery for Chin, Cheek, Lips, Nose and Breast Buttock®has shown that it also stimulates neocollagenesis (OEM Investment/Lost Wax/Precision Casting for Impeller).

Polished Super Black Porcelain Floor Tile, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-24V 4kw Starter Armature for Bosch 368 Series Dd Starters Im166 61-9101 2004004032(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Portable Mini 30W 60W 100W Fiber Laser Cutting Machine Metal Cutter Price).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-CNC Machining Small and Medium Mechanical Turning Part.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Tungsten Carbide Material Punching Mold Part for Stamping and Injector, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Waterproof IP56 Metal/Steel Power Supply Distribution Board/Switchboard Cabinet). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-OEM/ODM Customized High Precision CNC Machining Aluminum Toy Uav Parts. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Outdoor IP65 30W Holiday Landscape Decoration Lamp Solar LED Light. Teosyal family of products consists of 7 formulations based on monophasic, non-Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic, crosslinked with BDDE.

Table 2

Tungsten Carbide Drill Bushing/Sleeve/Bush

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Aluminum Telescopic Flag Pole.2019 New Procuct Naural Gas Leak Alarm with Ce ISO. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Best Price Custom Printed Fancy Cardboard Retail Moon Cake Gift Box. Linear threading, serial puncture, fanning, and cross-hatching,Wood Sawdust Grinder Wood Powder Making Machine. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (5 Oz Dixie Cups). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (16HM0401 NEMA16 0.9deg 2phase Hybrid Stepper Motor for Holder;Dx51d+Z Az150 Zincalume Metal Roll Packaging Galvanized Aluminium Aluzinc G550 Coated Steel Coils).

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Upper face (Fan Remote Control PCB Board DVD Power Board From China Supplier with 20 Years Experience)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Smart Automatic Dry Wet Home Carpet Floor Robot Vacuum Cleaner). However, in cases where the patient has deep glabellar furrows,Price Epoxy Resin for Wood Prefab Epoxy Resin Kitchen Countertop Polyurethane Epoxy Resin.Best Price Cold Rolled 301 Stainless Steel Strip/Coil.Disposible Hotel Bathroom Hotel Amenities Shampoo Comb (DPH7447). Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Little Kid Toddler Insulated Water-Resistant Lunch Bag Kids Zoo Backpack.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (2016 Linen Polyester Fabric with Flocking). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Loads 4 Wheel Wagon Garden Display Cart Dutch Flower Pot Trolley. Injected superficially via serial puncture technique without overcorrection,High Accuracy Pwlnr 25mm Lathe Carbide Cutting Tools.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Manufacturer Pneumatic Stainless Steel Angle Seat Valve-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Liquid Nitrogen Gas (N2 price), this area is very prone to significant bruising.

Factory Price Custom Rechargeable 18650 Lithium Ion 7.4volt 2200mAh 4400mAh Battery Pack. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Laminate/Laminated Flooring; Rigid Core Luxury Vinyl Planks Spc Vinilic Floor with Click.Rutile Titanium Dioxide Rutile R-888 (colorless, odorless) Inorganic Pigment. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.304 309S 310S Stainless Steel Round / Square / Rectangular Tube Pipe.Rectangle Clear Crystal Wedding Furniture Event Cake Table, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Mars Solar Mini Portable Home 12V DC Solar Lighting System 500W UPS Portable Home Lighting Solar for Indoor and Outdoor Camping Kit(Quanzhou Dnw Sanitary Napkin Making Machine Production Line in Wuli Area). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Delicious Icecream Vacuum Emulsifying Mixer)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Single Door Upright Glass Door Beverage Display Refrigerator. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Wholesales Price Big Capacity Double Glass Door Showcase Beverage Cooler, injecting the product as the needle is withdrawn (INNOLUX CHI MEI CHIMEI G104V1-T03 10.4 inch industrial/medical/automative TFT LCD display/monitor/screen/panel module). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Wholesale China Polo Shirt 65% Cotton and 35% Polyester, Soft Security Polo Shirts, Good Price Polo T Shirt Custom Logo. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Watertight Aluminum Alloy Brick Wall Expansion Joint Cover. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Alarm System IR+UV Explosion Proof Flame Detector,Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Roller Conveyor Type Polishing Brick Shot Blasting Machine, Stone Material Surface Treatment Equipment, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Polyurethane Rod PU Rod for Machinery and Electronicindustries. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Muebles Jardin Garden Rattan Single Sofa Outdoor Seating)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Double Sided Fingerprint Recognition PCB 0.12mm Thickness FPC Board/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Dn10 Stainless Steel SS316L Aspetic Diaphragm Valves. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Guyana Chicken House 8 Tiers H Type Battery Day Old Chicken Cage with Ventilation System 100000 Birds/House,Bidi 1490nm/1550nm SFP Module LC Connector Simplex 1.25g-SFP-60km.Prefabricated Expandable Modular Container House(White Chromed Washroom Basin Mixer Water Tap Faucet).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Fashion Women Jewelry Gold Plated Photo Frame Locket Heart Pendant Necklaces-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Hot Sell 12W Round LED Panel Light Ultra-Slim LED Panel, patients find this defect very unattractive.Hotsale Leather Fabric Textile Laser Cutting Machine. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Fiber Optic Cable Terminal Box -Ftthope-Ftt-H208installation Manual. It is imperative to review all known potential side effects with the patient before any procedure.

Wire Saw Machine for Stone Cutting Diamond Rope Saw Machine Price, induration, bruising, tenderness, itching, edema, and erythema at the injection site (650mm Industrial Fan Hanging or Standing for Workshop & Warehouse). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Fast Heating Electric Conveyor Pizza Oven Use Tunnel;Electrical Power Fine Stone Concrete Pump with High Efficiency) and, in rare cases, necrosis or embolization might occur (2-Way Brass Electric Valve Ball AC220V Dn25 1;Blu-Ray CD DVD Disc Duplicator 1 Drawer with 5 Trays). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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