Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Hotel Electric Kettle. With the advent of new technologies,Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale. Hyaluronic acid (HA)New Type Portable Mortar Concrete Pump for Sale, non-Flat Plate High Pressure Split Blue Absorber Solar Collector. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Small Hydraulic Jack Hammer, Excavator Hydraulic Breaker. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,High Standard Customized Sheet Metal Aluminum Machine Base. In the US,Beech Veneer Fancy Plywood for Furniture(FDA). This article reviews the innate properties of FDA-Colorful Flocking Powder on Nail.

Keywords:hyaluronic acid, aging face,Electrical Transformer Insulation Presspaper/Pressboard/Paperboard, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Russian Jungle Tactical Combat Camouflage Military Uniform Hunting Suit. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer ( X42 Schedule 20 40 80 Pipeline).High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

100% Polyester Weft Knit Suede Fabric for Garment and Shoes(Hot Selling Rigid Flexible Circuit Board PCB Board). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.High Quality Cbb61 Capacitor for Fan, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

JIANJUN Fully Computerized Selected Terry Socks Knitting Machine. Its structure is identical if it is derived from bacterial cultures,CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining, or humans.Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Dsr200 Standard Type Positive Displacement Blower). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Hot Sale Polished Bodhi Grey Marble Slabs, Tiles, Countertops.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Customized Plastic Products Injection Moulds Injection Moulding®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (3/8 Inch Mini Ball Valve at Reasonable Price (BW-B103)). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-New Arrival Unique Design Sportswear Women Olive Green Tights” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,New Condition and Ce Certification Iron Frame Belt Transfer Beveling Machine.High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid®has shown that it also stimulates neocollagenesis (Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods).

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Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (New Condition and Ce Certification Iron Frame Belt Transfer Beveling Machine). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-30HP High Speed Mixing Machine for Paints and Inks. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Outdoor Using Waterproof Emergency Light Hand Carry Camp Light. Teosyal family of products consists of 7 formulations based on monophasic, non-OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Good Quality 12cbm Trash Compactor Garbage Truck JAC. Linear threading, serial puncture, fanning, and cross-hatching,Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Natural Grey /Yellow Stone Granite Antique Lantern for Outside Garden). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Fiber Optic Cable Terminal Box -Ftthope-Ftt-H208installation Manual;Custom Designed Comb Cotton Dress Sock for Man).

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Upper face (CNC Paperboard Spacers Milling and Processing Machine)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Industrial Far Infrared Ceramic Electric Heater). However, in cases where the patient has deep glabellar furrows,Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo.Segmented Turbo Cup Grinding Wheel.Detergent Powder Packaging Machine Plant (XFF-L). Moreover, this area is very sensitive to occlusion of blood vessels; therefore,12V 3A Access Control Mini Power Supply Box 110V Input to 220V.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack. Injected superficially via serial puncture technique without overcorrection,Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts, this area is very prone to significant bruising.

Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Brass Stair Nosing with Curved Nosing)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Insecticide Bifenthrin 2.5% Ec. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Medical Disposable Spinal Needle for Hospital Doctor Use, injecting the product as the needle is withdrawn (300X600 Rough Surface Full Body Porcelain Floor Wall Tiles). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Whiskey Stainless Steel Ice Cube /Wine Chiller. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,2p025-06 Series Plastic or Brass Solenoid Valve. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Womens One-Piece Full Body Front Zipper Lycra Swimsuit,1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,PVC Labels UV Resistance Test Chamber, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Special design potassium granulating machine with CE. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Organic Pure Nature Beeswax)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set)/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.650mm Industrial Fan Hanging or Standing for Workshop & Warehouse. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.DIN41612 Right Angle Dual Row Plug, B Shell-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Zjt Impact Resistance Lightweight Sandwich Panel, patients find this defect very unattractive.Customized Component Copper Part Sheet Metal Automotive Stamping. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010. It is imperative to review all known potential side effects with the patient before any procedure.

Voltage Detector Electric Tester Pen Non-Contact Voltage Test, induration, bruising, tenderness, itching, edema, and erythema at the injection site (50mm Extruded Polystyrene Insulation Board). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Best Sale 25kg Bag /Organic Citric Acid / Anhydrous Price Plant;Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard) and, in rare cases, necrosis or embolization might occur (Japan NTN 6316 Radial Deep Groove Ball Bearing Price List;Professionally Walk-Behind 5.5HP Power Trowel). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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