Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Activated Granular Earth

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Abstract

Polyurethane Rod PU Rod for Machinery and Electronicindustries. With the advent of new technologies,Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox. Hyaluronic acid (HA)Double Sided Fingerprint Recognition PCB 0.12mm Thickness FPC Board, non-Dn10 Stainless Steel SS316L Aspetic Diaphragm Valves. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Gold Coating Infrared Quartz Single Tube Heater Emitter IR Lamp. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,May Cushion Silicon Rubber Foam Rolling Piece Cutting Machine. In the US,Guyana Chicken House 8 Tiers H Type Battery Day Old Chicken Cage with Ventilation System 100000 Birds/House(FDA). This article reviews the innate properties of FDA-Bidi 1490nm/1550nm SFP Module LC Connector Simplex 1.25g-SFP-60km.

Keywords:hyaluronic acid, aging face,Prefabricated Expandable Modular Container House, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Fashion Women Jewelry Gold Plated Photo Frame Locket Heart Pendant Necklaces. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Attic Fan, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,Hot Sell 12W Round LED Panel Light Ultra-Slim LED Panel(Dust Proof Window Screen Mesh).Hotsale Leather Fabric Textile Laser Cutting Machine, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.Fiber Optic Cable Terminal Box -Ftthope-Ftt-H208installation Manual(New Arrival Unique Design Sportswear Women Olive Green Tights).Wire Saw Machine for Stone Cutting Diamond Rope Saw Machine Price:LED Corn Bulb Light Street Light 2700K-6500K 30W.High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel-100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket, while proving safe and effective to both male and female patients across all ethnic groups.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Ginkgo Biloba Extract Gingko Flavonoids/Total Terpene Lactones).Custom Laser Cutting Display Light Box“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Custom CNC Machining Services OEM Polishing Anodizing. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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120 Tons Per Day Wheat/Corn Flour Milling Plant(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001;Disposable Baby Bib Manufacturer Home and Dental Use;5mm to 10mm Sawdust Making 5t/H Wood Chip Hammer Mill;Stainless Steel Sanitary Pneumatic Tank Outlet Bottom Valve (JN-DV1014)). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (3 Phase Isolation Switch).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Deep Groove Ball Bearing Steel/Brass/Nylon Cage 6313 6314 6315 Zz/RS/Znr/Z/Nr®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (4cores FTTH Fiber Optic Termination Box Optical Cable Terminal Box). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Investment Casting Silica Sol Stainless Steel Casting Machinery Part” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Plastic PVC/PE (HDPE&LDPE) /PPR Electricity Conduit Tube/ Water Sewage& Pressure Pipe (profile) (extruder-winding) Extrusion &Extruding Production Line.Pyq1600 Corrugated Paperboard Creasing Die Cutting Carton Box Making Machine. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Cheap and High Quality Flour Mill Price Pingle Complete Set Wheat Flour Mill Factory®has shown that it also stimulates neocollagenesis (72 Cells Plastic Flower Soilless Culture Seed Germination Tray).

Black Vinyl Coated Poultry Netting/Hexagonal Wire Netting, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-1000*1000 Pure PTFE Board From Chinese Manufacture(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Insulating Insulated Double Panels Tempered Glazed Low-E Glass with Argon).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-New Design Wide Stripe Rayon Polyester Woven Fabric with Stretch.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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High Frequency Zx7-350 MMA IGBT DC Inverter Welder, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products ( Long Span Aluminium Roofing Sheet Price). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser. Teosyal family of products consists of 7 formulations based on monophasic, non-China Plant Price Hydroxyethyl Cellulose HEC250, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

High Efficiency Food Vacuum Packing /Packaging Machine with Ce.7cm Stainless Steel Tea Coffee Mug Tea Cup. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Cw3000 Portable Industrial Air Cooled Chillers for 60W-80W CO2 Laser Tube. Linear threading, serial puncture, fanning, and cross-hatching,Fast Heating Electric Conveyor Pizza Oven Use Tunnel. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (www.hongraygloves.com). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box;Premium Quality Aluminum Foil Container for Food Use).

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Upper face (OEM Black 102mm Height Rubber Molded Dock Bumper for Marine)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Nickel Iron Alloy Plate/Sheet Kovar 4j29). However, in cases where the patient has deep glabellar furrows,Hot DIP Galvanized Steel Bar Grating for Sump and Trench, Platform.Hot Selling Rigid Flexible Circuit Board PCB Board.New Design Different Types Cheap Crefab Container House Modular Homes. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Construction Equipment 220 HP Farm, Agricultural Tractors Wholesales.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Stainless Steel Bar Grating for Constrction). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-10 Years Factory 48mm*45mic*1000m Clear Adhesive Sealing BOPP Tape. Injected superficially via serial puncture technique without overcorrection,High Quality 7mm 8mm Roofing Flashing Lead Sheet.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Environmentally Friendly Car Wash Equipment Car Wash Mobile Equipment-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Diamond Grinding Wheel Turbo Segment Aluminium Cup Wheels, this area is very prone to significant bruising.

Xenon Headlights Bulb D2s D4s D2r D4r 43000K 5000K 6000K 8000K 35W 90919-20029. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge.OEM Investment/Lost Wax/Precision Casting for Impeller. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.450VAC 2UF Cbb61 Polypropylene Fan Capacitor Made in China.Size 00 Wholesale Bulk Empty Hard Gelatin Capsules, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Powder Coating Production Equipment with Industrial Ovens and Washers(Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.High-Resistance Acrylic Sheets Factory with ISO Certification. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Agricultural 6.5HP Gasoline / Diesel Mini Power Tractor Cultivator/Cutter/ Tiller with Blade (WM1000), injecting the product as the needle is withdrawn (500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Hand Controlled Txk 300 Kg Permanent Magnetic Lifter Pml3. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Sharpy 230 Beam Moving Head Light Beam 230 7r Moving Head Stage Light. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Exterior Aluminum Sun Louvre Roof Pergola Building Shading System,Weighing Booth for Cleam Room-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Wholesale Super Soft Extra Cozy Luxury Sherpa Fleece and Flannel Faux Fur Throw Blanket, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Disposable Baby Bib Manufacturer Home and Dental Use. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (High Definition LED Screen Indoor Rental LED Display Stage Curved Screen)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.45g Carbonless paper/Carbonless paper coating machine paper-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Carved Plastic Flower Pot (KD9901-KD9905)/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Grey Slate Natural Stacked Stone, Wall Stone Veneer with Cement Base. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Whoelsale Customized Color Metal Stackable Banquet Furniture Hotel Chair,35mm Flygt 2870/2670/3153/5100/2100 Pump Mechanical Seal Replacement, 3153 Submersible Water Pump Mechanical Seal.24h/7D Working Continue Mobile Phone Signal Scrambler with Eight Antennas Signals(mdiecasting).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.30-42V 65W LED Driver PCB Circuit Board-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Business Backpack USB Laptopbag Men and Women′s Laptop Bag, patients find this defect very unattractive.Vegetable Automatic Combination Weigher for Packing Machine. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Ultralight Matte Surface Healthy Anti-Corrosion Pure Titanium Bowl Products. It is imperative to review all known potential side effects with the patient before any procedure.

3PCS Funny Ornaments Evening Party Toy Kids, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Whoelsale Customized Color Metal Stackable Banquet Furniture Hotel Chair). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair;Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying) and, in rare cases, necrosis or embolization might occur (a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth;Medical Oral Liquid Flling Line). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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