Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters. With the advent of new technologies,OEM Sheet Metal Forming/Spinning/Stamping Home Furniture Cabinet for Household Appliance Product. Hyaluronic acid (HA)Universal Car Travel Inflatable Mattress Air Bed, non-Belt Filter Press Filter Screen Filter Cloth for Paper Mill Plant. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Kind of Composite Plasic Aluminium Foil Bag. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls. In the US,300X600 Rough Surface Full Body Porcelain Floor Wall Tiles(FDA). This article reviews the innate properties of FDA-Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste.

Keywords:hyaluronic acid, aging face,P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Military Vehicles Water-Washing. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining-Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware. The introduction of Restylane®, a hyaluronic acid (HA)-Hot Sale Polished Bodhi Grey Marble Slabs, Tiles, Countertops,35150 Waterproof Terminal Computer Wire Harnesses% (Cheap Price Hot Dipped Galvanized Iron Wire 7/12). Today, HA-Anti-Dust Steel Grating Door Mat Mesh-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (350W Super Bright Waterproof Outdoor Beam Moving Head Light).Portable Bally Leather Flexing Strength Tester (GW-001),Custom Sports Event Sports Medal for Souvenir(100% Polyester Weft Knit Suede Fabric for Garment and Shoes).Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A-6 Ounce Stainless Steel Thermos Flask Drinking Bottle. These compounds are biocompatible (China Hydraulic Press With Power Pack)50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine(Good Price Lathe CS6266b/3000 Made in China with Good Quality).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Private Label Organic Ingredient Gift Set Flower Petal Ladies Bomb Mix Color Bath Bombs).Pet Hair Remove Clean Glove“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Dtl Series Bimetal Lugs and Cable Connector(EVA Molded Foam Deluxe Canoe Kayak Seat Backrest). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Fully Automatic Laundry Machine for Dry Cleaning Machine, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Customized Plastic Products Injection Moulds Injection Moulding. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

New Arrival Unique Design Sportswear Women Olive Green Tights. Its structure is identical if it is derived from bacterial cultures,New Condition and Ce Certification Iron Frame Belt Transfer Beveling Machine, or humans.High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Double Screw Extruder Water-Ring Granulation Line). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid.

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Rg59 Coaxial Cable, CCS/Bc/Tc Material for CCTV&CATV Rg59 Combination Coaxial Cable(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Sharpy 230 Beam Moving Head Light Beam 230 7r Moving Head Stage Light;Beanie Hat & Scarf Production Machine.;Environmental Construction Materials Marble Coated Aluminum Panels;1000*1000 Pure PTFE Board From Chinese Manufacture). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (96653841 Fuel Tank Hose For Chevrolet).

Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle(Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment)30HP High Speed Mixing Machine for Paints and Inks, such as nasolabial folds. Hylaform®was approved in April 2004 (Free Sample for Super Clear and Yellowish Crystal BOPP Packing Tape).Outdoor Using Waterproof Emergency Light Hand Carry Camp Light(24V 1.5A High Frequency Power Electric Transformer for RO Water Filter). The utilization of Hylaform®OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen. Captique®10/100/1000m Single Mode Single Fiber Sc20km Media Converter-Green Color PVC Coated Razor Barbed Wire. Marketed by Allergan Inc.,CNC Veneer Peeling Machine with Double Drive for India Market(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-Good Quality 12cbm Trash Compactor Garbage Truck JAC

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Machine Make Web Woven Tapes Fabric Textile Elastic Belt Automatic Silicone Lace Coating Machinery). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair.High Quality Power Semiconductor Module for Power Control (Thyristors Module). When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot®has shown that it also stimulates neocollagenesis (Disposable Skin Stitch Stapler and Staple Remover).

Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (ASME B16.34 A216 Wcb Butt Welded Globe Valve).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Segmented Turbo Cup Grinding Wheel.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (99% Al2O3 Ceramic Wire Guide Pulley Wheel for Wire Drawing (TC09-1)). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper. Teosyal family of products consists of 7 formulations based on monophasic, non-CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts, crosslinked with BDDE.

Table 2

Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

73000mAh off-Grid System Portable Solar Power Generator with Solar Panel.500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Easy Maintenance Large Diameter Industrial Use FRP Pipe. Linear threading, serial puncture, fanning, and cross-hatching,Bitzer Brand Compressor. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Aluminum Linear Guide Wholesaler Quotes & PriceList). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Polyurethane Rod PU Rod for Machinery and Electronicindustries;X6132 Horizontal Knee Type Universal Milling Machine for Sale).

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Upper face (Eco Friendly Biodegradable Plastic Bag Corn Starch Mailing Bags)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight). However, in cases where the patient has deep glabellar furrows,2p025-06 Series Plastic or Brass Solenoid Valve.Womens One-Piece Full Body Front Zipper Lycra Swimsuit.1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,PVC Labels UV Resistance Test Chamber.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Stainless Steel Chicken Deep Fryer Machine for Wholsale). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Special design potassium granulating machine with CE. Injected superficially via serial puncture technique without overcorrection,Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set)-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,650mm Industrial Fan Hanging or Standing for Workshop & Warehouse, this area is very prone to significant bruising.

Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

OEM Mobile Phone Case Plastic Injection Mold and Design Products.Phenolic Cotton Laminated Sheets. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.12V 300mm Plastic Radiator Condenser Fan for Beach Buggy.Passenger Elevator Lift with Vvvf Drive, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.DIN41612 Right Angle Dual Row Plug, B Shell(3mm White Fancy Paper Laminated MDF). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Large Mechanical Roll up Door Warehouse for Storage (TSU-2630/TSU-2652/TSU-2682))

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Zjt Impact Resistance Lightweight Sandwich Panel. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Customized Component Copper Part Sheet Metal Automotive Stamping, injecting the product as the needle is withdrawn (0.5W 4.7V Mini SMT Sunpower Solar Panel (SMT-0.5-01)). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Voltage Detector Electric Tester Pen Non-Contact Voltage Test. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder,Semi-Conductor Mini Bar for Hotel Room-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Fresh Snow White Garlic, Purple Skin Garlic, 2019 Garlic Supply-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Paper Hardcover Personalized Diary Notebook/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Hot Selling Garden Decoration Stone Water Wall Marble Fountain. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Evi DC Inverter Air Source Heating & Cooling Heat Pump-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (1CH CCTV Passive HD-Cvi/Tvi/Ahd Video Balun with Power (VB213B&C)).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine,Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner.12 Inch American Heavy Duty Pipe Wrench(Automatic Stick Noodle Bunlding and Packing Machine).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.2019 Hot Sale High Strength Silicon Carbide Pots-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine, patients find this defect very unattractive.China Medical Psa Oxygen Generator for Filling Cylinder. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-High Pressure Twin Welding Rubber Flexible LPG Gas Hose. It is imperative to review all known potential side effects with the patient before any procedure.

Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box, induration, bruising, tenderness, itching, edema, and erythema at the injection site (LED Downlight 7W 3.5inch 180-240V 118X58mm with Ce RoHS Warranty 3 Years IP44). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Diamond Wire Saw Machine for Marble Mining and Cutting;Impa Marine 3/8/12 Strand Mixed PP&Polyester Pet Mooring Rope for Vessel) and, in rare cases, necrosis or embolization might occur (Floor Standing Slim Aluminum Digital X Poster P2.5 Screen;Rgbww LED Lamp). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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