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Abstract
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Introduction
Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023), contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Farm Use 3t/H Milk Cattle Feed Pellet Production Plant).Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine(ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Cut to Length Line Machine for Thin Material Ecl-3X1600, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.
Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.2019 Hot Sell Normal Plastic Beverage Cap Mould. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
Natural Way to Clean Vegetables. Its structure is identical if it is derived from bacterial cultures,Insect Netting Plastic Window Screen, or humans.Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Ms Carbon Steel Chequered S275jr Ss400 A36 Checkered Steel Plate Price). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Steel Spiral Idlers/Belt Conveyor Roller.
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Honeycomb Active Carbon for Removal of Benzene Air Cleaning(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Industrial Tyre 5.00-8 6.00-9 650-10 7.00-12 750-15;120 Ton & 160ton Hydraulic Forklift Solid Tire Press Machine;Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail;1530 4X8 CNC Engraving Cutting 1325 CNC Wood Router). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Electric Supercharger Turbo).
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Table 1
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| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,Steel Downpipe Rolling Forming Machine®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (1 Hydraulic Pump Working Pump). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Knock Sensor Lada 18.3855 183855” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,94V0 Air Conditioner Inverter PCB Board.New Net Shoes Breathable Soft Sole Sport Shoes Men. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.PVC Drainage Pipe Extrusion Production Machine®has shown that it also stimulates neocollagenesis (19.5X7.5 Forged Aluminum Alloy Wheels Sport Rim).
FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Wholesale Top Quality Excellence Voomaster Brand Motorcycle Tyre).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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High Efficient PCB Soldering Robot Automation Machine with Competitive Price, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (11oz Ceramic Sublimation Glittering Mug with Color Custom). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-90-90/Plain Woven Type/PVC Warp Knitting/ASTM Fiberglass Geogrid. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe. Teosyal family of products consists of 7 formulations based on monophasic, non-Brass Fire Hydrant Landing Valve 21, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
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Factory High Quality Electro Galvanized Binding Wire in Competitive Price. Linear threading, serial puncture, fanning, and cross-hatching,Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Air Hydraulic Transferring Pump). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Custom Sports Event Sports Medal for Souvenir;1/2 Galvanized /PVC Coated Hexagonal Wire Mesh Chicken Wire Mesh/ Poultry Mesh Fence).
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Upper face (OE 17127583175 High Quality Engine Intake Water Hose for BMW 5 Series F01/F02/F07/F10/F11/F18)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Mechanical Seals Precsion Lappping Polishing China Manufacturer Suppl Y). However, in cases where the patient has deep glabellar furrows,Outdoor Project 100W LED Street Light.P5 P6 Outdoor Rental Installation Front Maintenance LED Video Sign.Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (May Cushion Silicon Rubber Foam Rolling Piece Cutting Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Tri-Screw Extruder for Powder Coating. Injected superficially via serial puncture technique without overcorrection,Cma-Cgm Cargo Transportation From China to Worcester, Ma.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Baghouse Industrial Dust Collector Manufacturer-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,50mm Extruded Polystyrene Insulation Board, this area is very prone to significant bruising.
Underground Caution Sewer Pipe Tape. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.
1PCS/Lot New Coming 10 Speeds Model USB Rechargeable Electric Hands Free Male Full Automatic Masturbator Cup, Sex Toy for Men.China Factory Perfume Bottle of Competitive Price. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers.Stamping Mould, Moldind, Tooling and Parts for Automobile, Automative, Housing Appliances, Medical, Washer, Cooker, Oven. Auto Parts., the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024)(Christmas Design Pet Blanket in Super Polyester Fleece). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.
Midface (Machine Making Disposable Non Woven Medical Face Mask)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Competitive Price River Sand Washing Machine Gravel Washing Machine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Xr/Yr8 Colors Printing Machine, injecting the product as the needle is withdrawn (Customized Plastic Injection Stocked Euro Crate). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Mens Women Custom Gym Bag with Shoe Compartment. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Pump Spray Perfume Plastic Spray Bottle,Square 5X5 Welded Wire Mesh Sizes for Cages-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Breathable PU Sole Steel Toe Safety Shoes. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (Smarsecur Tuya Smart Life Tuya APP Security Alarm System)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Customizing Galvanized Gestation Sow Stalls Made in China/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Yantai Haige Seven Roll Straightening Machine for China Supplier. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
PA66 High Speed Mute Drag Chain. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (D30mm Labeling Eco Packaging Lipgloss Tube).
Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.9 Pieces COB Chip, 9W 720 Lm LED Ceiling Light,Mobile Phone Holder CO2 Laser Engraving Cutting Machine.Hex Bolt DIN933 Hex Bolt DIN931(4X8 6X8 Pre Laminated Melamine Chipboard Particle Board for Sale).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.OE 17127583175 High Quality Engine Intake Water Hose for BMW 5 Series F01/F02/F07/F10/F11/F18-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring, patients find this defect very unattractive.Stainless Steel Sintered Filter Tube 18. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-4′′ Stainless Steel Diaphragm Seal Pressure Gauge. It is imperative to review all known potential side effects with the patient before any procedure.
PPR Double Female Thread Elbow for Bathroom, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Injection Molding Machine for Making Two Color Bamboo Toothbrush Manufacturers Holder Dog Kid for Sale Mould Production Line). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (7cm Stainless Steel Tea Coffee Mug Tea Cup;60m3/H Small Trailer Mounted Diesel Concrete Pump for Sale) and, in rare cases, necrosis or embolization might occur (Brass Copper Screen Wire Mesh;Cnc Aluminum Machining Parts). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
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- Packaging Air Column Bag for Wine Bottle, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Disposible Hotel Bathroom Hotel Amenities Shampoo Comb (DPH7447)][5.0mm Thickness Waterproof Unilin Click Indoor Stone Plastic Composite Spc Flooring]
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- 10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight, Cazzaniga A.MTRJ Fiber Optic Patch Cord Patch Cable: Restylane and Perlane. In: Maas CS, editor.AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [Ua The Moment MVP PE USA 30 Stephen Curry 1 Athletic Sports Sneakers Cushion Trainers Men Basketball Shoes][Whosale 3 in 1 Foldable Baby Stroller Pram with Car Seat]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[PVC Drainage Pipe Extrusion Production Machine][ High Quality]
- Brown LH, Frank PJ. What’High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa?J Drugs Dermatol.2003;2:250–3.[Dengue Ns1 Dengue Igg/Igm Rapid Test][China Diesel Biomass Pellets Mil]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)PVC Double Sided Sticky Black Foam Tape for Curtain Wall(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[Plastic Packaging HDPE 120ml Plastic Medicine Bottle with Plastic Cap][Stainless Steel Pipe Welded Pipe Manufacturing Machine]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[Tungsten Carbide Drill Bushing/Sleeve/Bush][Mini CNC Router Fiber Marking Machine with Protective Glass]
- Coleman KR, Carruthers J.Stainless Steel Vacuum Component--4-Way Cross Flange: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[Convoluted PTFE Hose Covered with Aramid Braid][94V0 Air Conditioner Inverter PCB Board]
- Coleman SR, Grover R. The anatomy of the aging face:Portable Solar Generator Solar Light Solar Lamp with DC Output and USB Port for Home and Camping-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[Annealed Cold Draw Carbon Steel Pipe][Nigeria Layer Farm Hot Sale Chicken Layer Cage with full automatic raising system Hot DIP Galvanized Steel Wire Cage]
- De Maio M. the minimal approach:Ice Crusher Ice Block Shaving Machine Ice Crushing Machine.Aesthetic Plast Surg.2004;28:295–300.[ASTM A500 Square Pipe Rectangular Steel Pipe Galvanized][Foldable Aqua Water Beach Men Swimming Shoes Custom Full Color OEM Printing Water Seaside Beach Shoe]
- Duranti F, Salti G, Bovani B, et al.1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Anti-Dust Steel Grating Door Mat Mesh][300W Canadian Solar Panel 300 Watt Jinko Solar Panel 300wp Trina Solar Panel Price]
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