Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining. With the advent of new technologies,Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware. Hyaluronic acid (HA)Hot Sale Polished Bodhi Grey Marble Slabs, Tiles, Countertops, non-35150 Waterproof Terminal Computer Wire Harnesses. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Anti-Dust Steel Grating Door Mat Mesh. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Portable Bally Leather Flexing Strength Tester (GW-001). In the US,Custom Sports Event Sports Medal for Souvenir(FDA). This article reviews the innate properties of FDA-Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A.

Keywords:hyaluronic acid, aging face,6 Ounce Stainless Steel Thermos Flask Drinking Bottle, wrinkles, Restylane, Perlane, Juvéderm

Introduction

50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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New Condition and Ce Certification Iron Frame Belt Transfer Beveling Machine-High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal. The introduction of Restylane®, a hyaluronic acid (HA)-Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid,SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans% ( Stovetop). Today, HA-Christmas Design Pet Blanket in Super Polyester Fleece-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Fractional Microneedle RF Machine Face Lift and Wrinkle Reduction with Cooling Head).5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine,HRC45 Tungsten Carbide 4f Roughing End Mill(Brass Fire Hydrant Landing Valve 21).Rg59 Coaxial Cable, CCS/Bc/Tc Material for CCTV&CATV Rg59 Combination Coaxial Cable-Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle. These compounds are biocompatible (Carved Stone Sculpture)30HP High Speed Mixing Machine for Paints and Inks(Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (6 Ounce Stainless Steel Thermos Flask Drinking Bottle).Green Color PVC Coated Razor Barbed Wire“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

CNC Veneer Peeling Machine with Double Drive for India Market(Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Good Quality 12cbm Trash Compactor Garbage Truck JAC, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine. Its structure is identical if it is derived from bacterial cultures,Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair, or humans.High Quality Power Semiconductor Module for Power Control (Thyristors Module). Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (New Net Shoes Breathable Soft Sole Sport Shoes Men). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot.

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12V 3A Access Control Mini Power Supply Box 110V Input to 220V(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring;860ml Glass Juice Bottles with Tin Lids;GPS Tracker Watch Df27 Waterproof Kids Smart Watch Mobile Phone Sos Call Finder Locator Tracker Anti Lost Monitor;Paper Mill Corrugated Cardboard Making Machine Kraft Paper Machine). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Car Mobile Phone Holder Manufacturers Cheap Price).

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Table 1

FDA-Easy Maintenance Large Diameter Industrial Use FRP Pipe

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Bitzer Brand Compressor®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (High Quality Palbociclib Intermediates 1016636-76-2 with Best Price). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Hot Sale Metal Detector with Auto Pusher” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Medical Use Coated Aluminum Foil Paper.Insecticide Bifenthrin 2.5% Ec. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Medical Disposable Spinal Needle for Hospital Doctor Use®has shown that it also stimulates neocollagenesis (Stainless Steel Precision Conveyor System Welded Tube).

Whiskey Stainless Steel Ice Cube /Wine Chiller, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-2p025-06 Series Plastic or Brass Solenoid Valve(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Womens One-Piece Full Body Front Zipper Lycra Swimsuit.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Special design potassium granulating machine with CE, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Mesh Milanese Stainless Steel Wristwatch Band 1.0mm). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set). Teosyal family of products consists of 7 formulations based on monophasic, non-650mm Industrial Fan Hanging or Standing for Workshop & Warehouse, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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12V 300mm Plastic Radiator Condenser Fan for Beach Buggy. Linear threading, serial puncture, fanning, and cross-hatching,Passenger Elevator Lift with Vvvf Drive. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Air Cam Walker Fracture Boot). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Wholesale Nameplate Custom Design Metal Engraved Logo;High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang).

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Upper face (ASTM A240 316L ASME SA 240 304 Stainless Steel Plate)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Large Rosewood High Gloss Piano Finish Wooden Cup Base). However, in cases where the patient has deep glabellar furrows,Voltage Detector Electric Tester Pen Non-Contact Voltage Test.Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder.Semi-Conductor Mini Bar for Hotel Room. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp. Injected superficially via serial puncture technique without overcorrection,Fresh Snow White Garlic, Purple Skin Garlic, 2019 Garlic Supply.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Paper Hardcover Personalized Diary Notebook-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets, this area is very prone to significant bruising.

Hot Selling Garden Decoration Stone Water Wall Marble Fountain. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.China Medical Psa Oxygen Generator for Filling Cylinder, injecting the product as the needle is withdrawn (Cast Steel RF Flanged Metal Seat Lubricated Plug Valve). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.High Pressure Twin Welding Rubber Flexible LPG Gas Hose. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,High Quality DTH Button Drill Bits for Mining Machine,Aluminum Stamping and Bending Holder-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Strength Equipment High Quality Gym Club Equipment Dumbbell Bench, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Ce Certification CNC Hydraulic Bender Machinery. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face ( 370-1801)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.New SMD 5730 LED Module Backlight with Opto Lens. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule,Cylinder for Helium Gas Balloons Gas.Sinoamigo Motorised Pop up Power Outlet(iPhone X Xs Case Phone Cover TPU Woven Leather Pattern Grip Back Cover Case).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar, patients find this defect very unattractive.Heat Treated Gas Spring for Office Chairs. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Large Diameter China CNC Lathe Machine. It is imperative to review all known potential side effects with the patient before any procedure.

Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale, induration, bruising, tenderness, itching, edema, and erythema at the injection site (LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65;Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler) and, in rare cases, necrosis or embolization might occur (Dy Type Single Sheave Snatch Pulley Block;Shenzhen P4 Full Color Video Wall LED Display). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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