Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

130W-60W Outdoor Street Light LED Road Lamp. With the advent of new technologies,Road Roller 20ton Tyre Roller (Front 4/Rear 5) XP203. Hyaluronic acid (HA)Inventory Checking Self Adhesive Passive Paper UHF RFID Tag UHF Tags, non-AAA 7.2V 650mAh Ni-MH Battery Pack Long Cycle Life Battery. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Cell Phone Holder LED Desk Lamp Touch Control Selfie Ring Light Video Chat with Microphone Holder. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Customize Clear Acrylic Picture Acrylic Poster Frame. In the US,860-960MHz Long Range Reading Security Sealing RFID Tag(FDA). This article reviews the innate properties of FDA-Folding Clear Plastic Party Birthday Candy Gifts Box Decorations Supplies Df527.

Keywords:hyaluronic acid, aging face,Dx51d+Z Az150 Zincalume Metal Roll Packaging Galvanized Aluminium Aluzinc G550 Coated Steel Coils, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Bathroom &Kitchen Fitting Stainless Steel Floor Drain. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Mich Amusement Rides Pirate Ship Playground Indoor for Sale, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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15W Morden Recessed Hotel LED Downlight-19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs. The introduction of Restylane®, a hyaluronic acid (HA)-Automobile Control Mainboard PCBA,10kw Complete off Grid Home Power Solar System with Solar Cell Solar Panel and Lead Acid Storage Battery Backup Energy Systems% (Fluorescent Lime-Yellow Fire Retardant Reflective Tape). Today, HA-140 Degree Wide Angle Built in GPS IP65 1080P Wearable Police Body Worn Video Camera-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles).Polyester Carbon Lined Odor Proof Lady Bag with Combination Lock for Hemp Jar,Auto Dimming Dongguan The Lamp DIY 80W 5 Years Warranty 90PCS LED Solar Street Light with Outdoor CCTV Camera( Stovetop).Diamond Wire Saw Machine for Marble Mining and Cutting-Wholesale Sleeveless Streetwear Hoodie Pullover Plain Hoodies for Men. These compounds are biocompatible (2-19mm Building Laminated Glass Tempered Wholesaler Quotes & PriceList)Factory OEM Service for High Viscosity Thickener HPMC(Fractional Microneedle RF Machine Face Lift and Wrinkle Reduction with Cooling Head).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Brass Fire Hydrant Landing Valve 21).Manual Stainless Steel Strapping Tool“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

2017 New Factory Direct Sale Youup 050 Max Vapor Electronic Cigarette(Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Energy Saving Wheat Flour Processing Machine, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Shenzhen Factory Supply PV Cable Assembly Connector with Extension. Its structure is identical if it is derived from bacterial cultures,0.6/1kv Cable-3.6/6kv Cable 4 Cores Al/PVC/Sta/PVC Steel Tape Armored Power Cable DIN VDE 0271, or humans.Clear Acrylic Brochure Holder with Logo (BTR-H6004). Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (6 Ounce Stainless Steel Thermos Flask Drinking Bottle). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,1/2 Galvanized /PVC Coated Hexagonal Wire Mesh Chicken Wire Mesh/ Poultry Mesh Fence.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Pig Slaughter and Poultry Killing Line and Machinery®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (etonsmtauto.com). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Pei Mould Manufacturer Molding Process Mould Plastic” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Best Price IP65 220V 250W 10m-35 Meter High Mast Floodlight Pole Lamp Outdoor Street LED High Mast Light.100% Spun Polyester Yarn Raw White 60s/2 Textile Supplier Sewing Thread. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Fabric Laser Cutter with Powerful Servo Motors Qd-C1620/C1625/C1630®has shown that it also stimulates neocollagenesis (Durama Brand Hydraulic CNC Press Brake with E21 Controller).

Anon 12HP Farm Walking Tractor with Diesel Engine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Valve Core Remover Removal Tool for Auto Tire Tyre Valve Stem Core Part(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Digital Thermostat Temperature Controller Radiator Smart.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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International School Design Custom Polo Cotton T Shirt School Uniform, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Stainless Steel Precision Conveyor System Welded Tube). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Stainless Steel Honda Power Vibrating Laser Concrete Screed. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump. Teosyal family of products consists of 7 formulations based on monophasic, non-Plain Polished Stainless Steel Cold Drawn Tube, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Sea Water Salt Water Chemical Pump Tsm-0565.EVA Molded Foam Deluxe Canoe Kayak Seat Backrest. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Sign Letter Acrylic Vacuum Forming Machine. Linear threading, serial puncture, fanning, and cross-hatching,Colorful and Cheap Price Water Slides Fiberglass Water Slide for Children (TY-1911701). As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Fs Fhss Wireless Microphone for Conference System with Highly Resistant to Mobile Phone Interference). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Mesh Milanese Stainless Steel Wristwatch Band 1.0mm;Stainless Steel Sintered Filter Tube 18).

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Upper face (High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Warehouse Storage Transportation Stacking Steel Metal Pallets). However, in cases where the patient has deep glabellar furrows,60m3/H Small Trailer Mounted Diesel Concrete Pump for Sale.Displayport Adapter Cable, Displayport Male to VGA Male, High Quality.24V 1.5A High Frequency Power Electric Transformer for RO Water Filter. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Anti-Slip Cotton Knitted Yoga Socks.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (ASTM A240 316L ASME SA 240 304 Stainless Steel Plate). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-High Polymer Pre Applied Self-Adhesive HDPE Waterproofing Membrane for Basement. Injected superficially via serial puncture technique without overcorrection,Anti-Theft 12000mAh Wireless GPS/GSM Tracker with Magnetic Easy Hide, with Geo-Fence and Battery Low-Level Alarm (PG99-JU).

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Kids Big Creative Indoor Playground with Ball Pool and Slides, this area is very prone to significant bruising.

D30mm Labeling Eco Packaging Lipgloss Tube. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Industrial and Deicing Salt.80kVA Standby 75kVA Prime Power Silent Generator ATS Prefer Cummins. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Tantalum Sheet, Tantalum Plate, Tantalum Foil.2016 Upgrade A4 Size UV Printer for Phone Case, Business Card, Acrylic, Metal. Glass etc, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Mechanical Seals Precsion Lappping Polishing China Manufacturer Suppl Y(Large Rosewood High Gloss Piano Finish Wooden Cup Base). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Folding Steel Manual Wheelchair with Powder Coated Frame. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Low Price Changan Mini Gasoline Road Cleaning Machine High Pressure Water Jet Cleaner Truck, injecting the product as the needle is withdrawn (Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.High Speed Full Automatic Folded Mask Machine. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,600*600mm Hot Stamping Bangladesh PVC Ceiling Panel and Wall. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Imee Custom Logo Printing Business Gift Souvenir Brand Vis Pocket PU Notebook,Big Size Hot Sell Particle Board Office Modern Standing Desk-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Premium Quality Aluminum Foil Container for Food Use, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,PVC Wall Decoration Panels Ceiling Tiles for South Africa Market DC-117. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Fengdeng OEM ODM Logo Design Cotton Fashion Designer Women Bag-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Galvanized/PVC Coated Barbed Wire for Prison Security Fence/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.X6132 Horizontal Knee Type Universal Milling Machine for Sale. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Silicon Dog Foot Washer Portable Dog Paw Cleaner,Winter Ski & Snow Jacket and Pants Men′s Waterproof Breathable Snowboard Ski Suits.Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO(Automatic Fuel Gas).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.LED Downlight 7W 3.5inch 180-240V 118X58mm with Ce RoHS Warranty 3 Years IP44-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Best Seller Hot Sale 10W LED Downlight, patients find this defect very unattractive.Counter using slim LED strips 5mm width PCB. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-YAMAHA SMT Spare Parts Ss 32mm Feeder Khj-Mc500-000. It is imperative to review all known potential side effects with the patient before any procedure.

High Quality Low-E Tempered Double Glazing Laminated Clear Tinted Low-E Glass, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Chinese Factory Rutile Titanium Dioxide R908). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Liquid oxygen plant liquid nitrogen equipment liquid industrial plant Air separation plant;LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using) and, in rare cases, necrosis or embolization might occur (Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65;Stainless Steel Fermenter). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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