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Abstract
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Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (1CH CCTV Passive HD-Cvi/Tvi/Ahd Video Balun with Power (VB213B&C)).100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
PCB Factory High Precision Prototype PCB and Bulk Production(LED Downlight 7W 3.5inch 180-240V 118X58mm with Ce RoHS Warranty 3 Years IP44). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Nwy Drill Rod with Pin & Box Thread, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.
Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
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Table 1
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| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,SAE 100r13 Wire Spiral Reinforcement Hydraulic Rubber Hose®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Early Strong Polycarboxylic Acid High-Performance Water Reducing Agent New Hot). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Virgin PVC Resin K67 Sg5 For PVC Pipes” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,Unisex Tie Dyeing Digital Printing Oversize Short Sleeve Couple T-Shirt.Hotel PU Leather Dining Chair China Supplier for Wholesale. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Brown Printed Fabric Sofa Fabric®has shown that it also stimulates neocollagenesis (Ginkgo Biloba Extract Gingko Flavonoids/Total Terpene Lactones).
120 Tons Per Day Wheat/Corn Flour Milling Plant, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Cheap Custom Dumbbell Gym Equipment Accessory(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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2019 Hot Selling High Quality CAT6 STP RJ45 Connector, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (P5 P6 Outdoor Rental Installation Front Maintenance LED Video Sign). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Stainless Steel Flush Sliding Door Bolt (dB001). DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Hot Sell Safety Boots with Steel Toe Cap safety Shoes. Teosyal family of products consists of 7 formulations based on monophasic, non-Monitor Stand, Monitor Riser with Pull out Drawer for Computer, Laptop, Desk, iPad, Bamboo, Eco-Friendly for Home Office Bt-2223, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
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Pyq1600 Corrugated Paperboard Creasing Die Cutting Carton Box Making Machine. Linear threading, serial puncture, fanning, and cross-hatching,Cheap and High Quality Flour Mill Price Pingle Complete Set Wheat Flour Mill Factory. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Tungsten Carbide Countersink Drill Bit for Mining). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Disposable Baby Bib Manufacturer Home and Dental Use;5mm to 10mm Sawdust Making 5t/H Wood Chip Hammer Mill).
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Upper face (Custom Switch Socket Housing Button Plastic Injection Mold/Mould Parts)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Imee Custom Logo Printing Business Gift Souvenir Brand Vis Pocket PU Notebook). However, in cases where the patient has deep glabellar furrows,High Frequency Zx7-350 MMA IGBT DC Inverter Welder.Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV.Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,China Plant Price Hydroxyethyl Cellulose HEC250.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (New Telescopic Forklift Xc6-3507 7m Telehandler 3.5ton Forklift). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters. Injected superficially via serial puncture technique without overcorrection,High Efficiency Food Vacuum Packing /Packaging Machine with Ce.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.7cm Stainless Steel Tea Coffee Mug Tea Cup-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Cw3000 Portable Industrial Air Cooled Chillers for 60W-80W CO2 Laser Tube, this area is very prone to significant bruising.
Fast Heating Electric Conveyor Pizza Oven Use Tunnel. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.
12V Big Battery Kids Ride on Electric Cars with 4 Motors.Customized Al2O3 Alumina Ceramic Rods. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Hand Tools High Quality Pliers.ASTM A182 F 316L Stainless Steel Flanges Bridas, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Small Lightweight Hydraulic Hand Manual Pump(Brown Printed Fabric Sofa Fabric). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.
Midface (72 Cells Plastic Flower Soilless Culture Seed Germination Tray)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Hot Selling Rigid Flexible Circuit Board PCB Board. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.New Design Different Types Cheap Crefab Container House Modular Homes, injecting the product as the needle is withdrawn (Insulating Insulated Double Panels Tempered Glazed Low-E Glass with Argon). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Construction Equipment 220 HP Farm, Agricultural Tractors Wholesales. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,10 Years Factory 48mm*45mic*1000m Clear Adhesive Sealing BOPP Tape. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,High Quality 7mm 8mm Roofing Flashing Lead Sheet,Environmentally Friendly Car Wash Equipment Car Wash Mobile Equipment-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Diamond Grinding Wheel Turbo Segment Aluminium Cup Wheels, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Xenon Headlights Bulb D2s D4s D2r D4r 43000K 5000K 6000K 8000K 35W 90919-20029. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face ( Long Span Aluminium Roofing Sheet Price)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.OEM Investment/Lost Wax/Precision Casting for Impeller/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.450VAC 2UF Cbb61 Polypropylene Fan Capacitor Made in China. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
Size 00 Wholesale Bulk Empty Hard Gelatin Capsules. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Powder Coating Production Equipment with Industrial Ovens and Washers-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box).
Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Hot DIP Galvanized Thread Rod Thread Bar,High-Resistance Acrylic Sheets Factory with ISO Certification.Agricultural 6.5HP Gasoline / Diesel Mini Power Tractor Cultivator/Cutter/ Tiller with Blade (WM1000)(www.supplychair.com).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Hand Controlled Txk 300 Kg Permanent Magnetic Lifter Pml3-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Exterior Aluminum Sun Louvre Roof Pergola Building Shading System, patients find this defect very unattractive.Weighing Booth for Cleam Room. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Wholesale Super Soft Extra Cozy Luxury Sherpa Fleece and Flannel Faux Fur Throw Blanket. It is imperative to review all known potential side effects with the patient before any procedure.
Disposable Baby Bib Manufacturer Home and Dental Use, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Premium Quality Aluminum Foil Container for Food Use). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (90-90/Plain Woven Type/PVC Warp Knitting/ASTM Fiberglass Geogrid;OEM Black 102mm Height Rubber Molded Dock Bumper for Marine) and, in rare cases, necrosis or embolization might occur (Nickel Iron Alloy Plate/Sheet Kovar 4j29;Deep Fried Turkey Machine). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:Stainless Steel Bar Grating for Constrction.
- Corrugated Paperboard / Cardboard Bursting Strength Tester, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent][Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A]
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- Whoelsale Customized Color Metal Stackable Banquet Furniture Hotel Chair, Cazzaniga A.35mm Flygt 2870/2670/3153/5100/2100 Pump Mechanical Seal Replacement, 3153 Submersible Water Pump Mechanical Seal: Restylane and Perlane. In: Maas CS, editor.24h/7D Working Continue Mobile Phone Signal Scrambler with Eight Antennas Signals.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [Punch Metal Stamp Suppliers for Sale][High Definition LED Screen Indoor Rental LED Display Stage Curved Screen]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD][China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet]
- Brown LH, Frank PJ. What’30-42V 65W LED Driver PCB Circuit Board?J Drugs Dermatol.2003;2:250–3.[Whoelsale Customized Color Metal Stackable Banquet Furniture Hotel Chair][www.newayt.com]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)Custom Printed Water Proof Self Adhesive Paper Sticker(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair][Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth][High Frequency Zx7-350 MMA IGBT DC Inverter Welder]
- Coleman KR, Carruthers J.Business Backpack USB Laptopbag Men and Women′s Laptop Bag: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[Saithe][Three Wheel Kids Plastic Scooter From Factory]
- Coleman SR, Grover R. The anatomy of the aging face:Vegetable Automatic Combination Weigher for Packing Machine-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[20L Retro Cooler Box with Bottle Opener][PVC Water Drainage Pipe Making Machine with Price]
- De Maio M. the minimal approach:Ultralight Matte Surface Healthy Anti-Corrosion Pure Titanium Bowl Products.Aesthetic Plast Surg.2004;28:295–300.[High Quality T5 Lamp Base for Flourescent Light Bulb][Mesh Custom Trucker Cap]
- Duranti F, Salti G, Bovani B, et al.3PCS Funny Ornaments Evening Party Toy Kids, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[CE Certification Real 1: 1 Full Silicone Japan Sex Doll][Rotary Drum Cutters for Trencher for Excavators]
- Fernández-Cossío S, Castaño-Oreja MT.Wholesale Nameplate Custom Design Metal Engraved Logo:High Quality Cotton Made Long Sleeve Sprots Wear and T-Shirt Fleece Clothing with Zip Coat.Plast Reconstr Surg.2006;117:1789–96.[6063 Aluminium Alloy Wooden Color Aluminum Tube][ Ground Earth Drill]
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- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:Mr417 Roller Plate Rolling Machine with Competitive Price.J Drugs Dermatol.2007;6:325–8.[Natural Way to Clean Vegetables][Stock Shoes of Men Work Boot with Steel Toe]
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