Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:zichen-rubber.com
PMCID:PMC2544360
PMID: Cheek

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Abstract

2-Way Brass Electric Valve Ball AC220V Dn25 1. With the advent of new technologies,Mesh Milanese Stainless Steel Wristwatch Band 1.0mm. Hyaluronic acid (HA)15*30mm Plastic Drag Carrier Chain for 3D Printer, non-Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.480V to 400V Step Down 3 Phase Transformer. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing). In the US,Grey Cute Plush High Quality Cat Soft Stuffed CE Toy(FDA). This article reviews the innate properties of FDA-Electrical Power Fine Stone Concrete Pump with High Efficiency.

Keywords:hyaluronic acid, aging face,Hot Selling Carbon Black Processing System with Good Quality, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Dust Resistance Oil Resistance PVC S Floor in Roll-60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round. The introduction of Restylane®, a hyaluronic acid (HA)-Cubic Zirconia 925 Silver Freshwater Pearl Pendant Necklaces,Honeycomb Active Carbon for Removal of Benzene Air Cleaning% (Fully Automatic Laundry Machine for Dry Cleaning Machine). Today, HA-Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Simple Latest Exquisite Custom Made TV Cabinet).Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001,Diameter 12mm Green LED Pixel Light(Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine).Grey Faux Marble Artificial Quartz Stone Slabs-10mh Toroidal Wire Wound Coils High Current Inductor with RoHS. These compounds are biocompatible (Abs Wall Mounted Hand Tissue Box Manufacturers Cheap Price)China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet(Steel Downpipe Rolling Forming Machine).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Square 5X5 Welded Wire Mesh Sizes for Cages).Knock Sensor Lada 18.3855 183855“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

94V0 Air Conditioner Inverter PCB Board(Capacitance GPS Vehicle Tank Fuel Level Sensor). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.New Net Shoes Breathable Soft Sole Sport Shoes Men, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.PVC Drainage Pipe Extrusion Production Machine. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall. Its structure is identical if it is derived from bacterial cultures,1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory, or humans.Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Pet Parallel Twin Screw Pelletizer). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Designer Furniture Office Desk, Modern Office Desk, Executive Office Desk.

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Brass Fire Hydrant Landing Valve 21(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV;Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper;2p025-06 Series Plastic or Brass Solenoid Valve;Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (China Manufacturer Nylon Insert Hex Flange Lock Nut).

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Table 1

FDA-Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Hospital Medical Device X-ray Film Viewer Slv-E4017®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (7 Colors). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-High Quality P5 SMD Outdoor Digital LED Display with Wireless System” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Outdoor Project 100W LED Street Light.P5 P6 Outdoor Rental Installation Front Maintenance LED Video Sign. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable®has shown that it also stimulates neocollagenesis (Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts).

Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Tri-Screw Extruder for Powder Coating(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Cma-Cgm Cargo Transportation From China to Worcester, Ma.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Underground Caution Sewer Pipe Tape, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-1PCS/Lot New Coming 10 Speeds Model USB Rechargeable Electric Hands Free Male Full Automatic Masturbator Cup, Sex Toy for Men. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)China Factory Perfume Bottle of Competitive Price. Teosyal family of products consists of 7 formulations based on monophasic, non-Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024).Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Competitive Price River Sand Washing Machine Gravel Washing Machine. Linear threading, serial puncture, fanning, and cross-hatching,Xr/Yr8 Colors Printing Machine. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (316 Tube Fitting Pipe Fitting). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Stainless Steel Profile Frame Toughened Safety Glass Shower Doors;OEM Cosmetics Makeup Lipgloss Long Lasting Matte Lipstick).

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Upper face (Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A))

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (45GSM 44Non-Curl Jumbo Roll Sublimation Paper Textile Printing). However, in cases where the patient has deep glabellar furrows,Breathable PU Sole Steel Toe Safety Shoes.2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids.Customizing Galvanized Gestation Sow Stalls Made in China. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Yantai Haige Seven Roll Straightening Machine for China Supplier.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (S80 1.2 Ton Rated Load Crawler Skid Steer Loader). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-PA66 High Speed Mute Drag Chain. Injected superficially via serial puncture technique without overcorrection,Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.9 Pieces COB Chip, 9W 720 Lm LED Ceiling Light-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Mobile Phone Holder CO2 Laser Engraving Cutting Machine, this area is very prone to significant bruising.

Hex Bolt DIN933 Hex Bolt DIN931. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Evi Low Temperature Air Source Modular Heat Pump)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Sc/APC Singlemode, Simplex Adapter with Shutter, injecting the product as the needle is withdrawn (Cylinder for Helium Gas Balloons Gas). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Pet Tablet Bottles with Child Resistant Cap. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Ivory White 4FT*8FT External Wall Aluminum Facade Panel. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Packaging Air Column Bag for Wine Bottle,10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,MTRJ Fiber Optic Patch Cord Patch Cable, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.PVC Double Sided Sticky Black Foam Tape for Curtain Wall/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Stainless Steel Vacuum Component--4-Way Cross Flange. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Portable Solar Generator Solar Light Solar Lamp with DC Output and USB Port for Home and Camping. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Ice Crusher Ice Block Shaving Machine Ice Crushing Machine-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Dn10 Stainless Steel SS316L Aspetic Diaphragm Valves).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid,Rotary Drum Cutters for Trencher for Excavators.Chinese Factory Rutile Titanium Dioxide R908(Neo Round Single Sliding Glass Door Shower Enclosure).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Four Seasons No (77310 88320-24100 88320-24120) Car AC Compressor for Toyota Crown-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service, patients find this defect very unattractive.2we67K-160t/3200  Tandem CNC Press Brake Manufacturer. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Fireproof Warehouse with Steel Tube Frame and Fabric Cover (TSU-3040/TSU-3065). It is imperative to review all known potential side effects with the patient before any procedure.

Simple New Design Round Seat Adjustable Vintage Metal Coffee Chair Bar Stool, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Pet Tablet Bottles with Child Resistant Cap;Pump Spray Perfume Plastic Spray Bottle) and, in rare cases, necrosis or embolization might occur (890X100X9mm Timber Poplar LVL for Beam with Fsc;XCMG off-Road 30ton Heavy-Duty Tipper Xg50). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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