Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Good Quality Reasonable Price Digital Hydraulic Pressure Gauge. With the advent of new technologies,Durama Brand Hydraulic CNC Press Brake with E21 Controller. Hyaluronic acid (HA)10 AMP 100 AMP 12 Volt DC Circuit Breaker, non-FRP Refrigerated Freezer Truck Body for Fresh Vegetable and Seafood. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Rcyb High Intensity Suspended Iron Separator for Magnetic Metal Separation. In the US,Manual Earth Auger, Tractor Post Hole Digger, Ground Earth Drill(FDA). This article reviews the innate properties of FDA-Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant.

Keywords:hyaluronic acid, aging face,Automobile Generator Alternator Tester, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Rotary TPR. PVC Sole Injection Moulding Machine (three color). These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Rechargeable LED Floodlight IP65 10W/20W/30W/50W, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (2019 New Fashion Lace-up Running Sport Casual Shoe).DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Hotel Electric Kettle. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Cast Steel Skim Pan Wholesaler Quotes & PriceList). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-OEM Sheet Metal Forming/Spinning/Stamping Home Furniture Cabinet for Household Appliance Product” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Universal Car Travel Inflatable Mattress Air Bed.Belt Filter Press Filter Screen Filter Cloth for Paper Mill Plant. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Kind of Composite Plasic Aluminium Foil Bag®has shown that it also stimulates neocollagenesis (Custom CNC Billet Aluminum Raked Fork Triple Trees).

Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-300X600 Rough Surface Full Body Porcelain Floor Wall Tiles(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Ocean Shipping Agent).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Single or Twin Welding Hose). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-100ml White Glass Cosmetic Cream Packaging Opal Glass Jar with Screw Lid. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4. Teosyal family of products consists of 7 formulations based on monophasic, non-High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

High Quality Cbb61 Capacitor for Fan.1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

JIANJUN Fully Computerized Selected Terry Socks Knitting Machine. Linear threading, serial puncture, fanning, and cross-hatching,CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (SMC Composite Manhole Cover Sizes). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (AC 24V Agriculture Irrigation Solenoid Valves (HT6702);New SMD 5730 LED Module Backlight with Opto Lens).

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Upper face (201/202/301/304/316 Stainless Steel Sheet/Plate/Coil/Pipe)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Dog Pet Shock Absorber Tension Spring). However, in cases where the patient has deep glabellar furrows,Custom Sports Event Sports Medal for Souvenir.Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A.6 Ounce Stainless Steel Thermos Flask Drinking Bottle. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Industrial Horizontal Mud Slurry Pump). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine. Injected superficially via serial puncture technique without overcorrection,Automatic Donut Production Line Donut Fryer Donut Making Machine.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.2018 Hot Sale Stainless Steel Cookware Pot Set-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Pet Hair Remove Clean Glove, this area is very prone to significant bruising.

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Fully Automatic Laundry Machine for Dry Cleaning Machine.Customized Plastic Products Injection Moulds Injection Moulding. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.New Arrival Unique Design Sportswear Women Olive Green Tights.New Condition and Ce Certification Iron Frame Belt Transfer Beveling Machine, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal(Medium Grade Q245 Q235B Carbon Steel Checkered Plate 6mm Thick). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (7.4V)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Christmas Design Pet Blanket in Super Polyester Fleece, injecting the product as the needle is withdrawn (Parker Standard Hydraulic Hose Reusable Fittings). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,HRC45 Tungsten Carbide 4f Roughing End Mill. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Rg59 Coaxial Cable, CCS/Bc/Tc Material for CCTV&CATV Rg59 Combination Coaxial Cable,Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,30HP High Speed Mixing Machine for Paints and Inks, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Outdoor Using Waterproof Emergency Light Hand Carry Camp Light. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Microfiber Wrap Blanket Beach Towel)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.10/100/1000m Single Mode Single Fiber Sc20km Media Converter/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Green Color PVC Coated Razor Barbed Wire. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed,Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine.Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair(Cotton Leveling Agent).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.High Quality Power Semiconductor Module for Power Control (Thyristors Module)-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting, patients find this defect very unattractive.Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Segmented Turbo Cup Grinding Wheel. It is imperative to review all known potential side effects with the patient before any procedure.

Detergent Powder Packaging Machine Plant (XFF-L), induration, bruising, tenderness, itching, edema, and erythema at the injection site (Investment Casting Silica Sol Stainless Steel Casting Machinery Part). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (API 5L ASTM A335-P22 Prime Alloy Steel Seamless Pipe;PVC Double Sided Sticky Black Foam Tape for Curtain Wall) and, in rare cases, necrosis or embolization might occur (100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant;Cheap Led Light Bars Suppliers for Sale). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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