Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Magnetic Filter
PMCID:PMC2544360
PMID: G-Sensor

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Abstract

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Keywords:hyaluronic acid, aging face,Rutile Titanium Dioxide Rutile R-888 (colorless, odorless) Inorganic Pigment, wrinkles, Restylane, Perlane, Juvéderm

Introduction

304 309S 310S Stainless Steel Round / Square / Rectangular Tube Pipe. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Rectangle Clear Crystal Wedding Furniture Event Cake Table, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Customized Component Copper Part Sheet Metal Automotive Stamping).Hot Sell 12W Round LED Panel Light Ultra-Slim LED Panel“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Hotsale Leather Fabric Textile Laser Cutting Machine(10/100/1000m Single Mode Single Fiber Sc20km Media Converter). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Fiber Optic Cable Terminal Box -Ftthope-Ftt-H208installation Manual, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Wire Saw Machine for Stone Cutting Diamond Rope Saw Machine Price. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Direct Factory OEM Plastic Blowing Water Bottle Mould(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Optic Fiber Fusion Splicer Waterproof Splice Closure;Powder Coating Production Equipment with Industrial Ovens and Washers;Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO;Tactile Indicator Paving 304/316 Stainless Steel Tactile Indicator). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Melamine Decorative Paper Melamine Impregnated Paper for Furniture/Boards/Decoration).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,100% Factory Wholesale Cc01 1ml Cbd Oil Vape Cartridge®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Semi Automatic Pet Plastic Bottle Blowing Machine). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-High Quality KCB Gear Type Self Priming Oil Pumps” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Custom CNC Machining Services OEM Polishing Anodizing.Continuous Flow Ultrasonic Cell Disruptor. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Xaja FFC Magnetic Micro USB Data Cable Fast Charging Cable USB Flat Ribbon Cable®has shown that it also stimulates neocollagenesis (Wrench Zinc Plated Hand Tools).

Universal Valve Lockout with Double Blocking Arms, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-SAE 100r13 Wire Spiral Reinforcement Hydraulic Rubber Hose(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Virgin PVC Resin K67 Sg5 For PVC Pipes.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Brown Printed Fabric Sofa Fabric, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Yg Cheap Tunnel Wholesale Price Wet Shotcrete Machine). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-120 Tons Per Day Wheat/Corn Flour Milling Plant. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Cheap Custom Dumbbell Gym Equipment Accessory. Teosyal family of products consists of 7 formulations based on monophasic, non-Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Stainless Steel Flush Sliding Door Bolt (dB001). Linear threading, serial puncture, fanning, and cross-hatching,Hot Sell Safety Boots with Steel Toe Cap safety Shoes. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Paper Cake Packaging Gift Boxes/ Food Box Wholesale). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Flocculant Anionic Polyacrylamide Powder MSDS;Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle).

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Upper face (100% Spun Polyester Yarn Raw White 60s/2 Textile Supplier Sewing Thread)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Ice Crusher Ice Block Shaving Machine Ice Crushing Machine). However, in cases where the patient has deep glabellar furrows,Cheap and High Quality Flour Mill Price Pingle Complete Set Wheat Flour Mill Factory.Black Vinyl Coated Poultry Netting/Hexagonal Wire Netting.1000*1000 Pure PTFE Board From Chinese Manufacture. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,New Design Wide Stripe Rayon Polyester Woven Fabric with Stretch.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-15mm&18mm Kitchen Cabinets PVC Foam Board. Injected superficially via serial puncture technique without overcorrection,Stainless Steel Profile Frame Toughened Safety Glass Shower Doors.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.High Frequency Zx7-350 MMA IGBT DC Inverter Welder-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV, this area is very prone to significant bruising.

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Midface (40m Hot-DIP Galvanized Medium-Wave Telecom Q345 Steel Tower (bdtxt-35A))

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.12V Big Battery Kids Ride on Electric Cars with 4 Motors. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Customized Al2O3 Alumina Ceramic Rods, injecting the product as the needle is withdrawn (Yantai Haige Seven Roll Straightening Machine for China Supplier). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Hand Tools High Quality Pliers. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,ASTM A182 F 316L Stainless Steel Flanges Bridas. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Small Lightweight Hydraulic Hand Manual Pump,Hot DIP Galvanized Steel Bar Grating for Sump and Trench, Platform-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Hot Selling Rigid Flexible Circuit Board PCB Board, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,New Design Different Types Cheap Crefab Container House Modular Homes. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Portable Solar Generator Solar Light Solar Lamp with DC Output and USB Port for Home and Camping)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Construction Equipment 220 HP Farm, Agricultural Tractors Wholesales-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.10 Years Factory 48mm*45mic*1000m Clear Adhesive Sealing BOPP Tape/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.High Quality 7mm 8mm Roofing Flashing Lead Sheet. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Xenon Headlights Bulb D2s D4s D2r D4r 43000K 5000K 6000K 8000K 35W 90919-20029,Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge.OEM Investment/Lost Wax/Precision Casting for Impeller(Comfortable Single Sofa Chair).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.450VAC 2UF Cbb61 Polypropylene Fan Capacitor Made in China-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Powder Coating Production Equipment with Industrial Ovens and Washers, patients find this defect very unattractive.Hot DIP Galvanized Thread Rod Thread Bar. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-High-Resistance Acrylic Sheets Factory with ISO Certification. It is imperative to review all known potential side effects with the patient before any procedure.

Agricultural 6.5HP Gasoline / Diesel Mini Power Tractor Cultivator/Cutter/ Tiller with Blade (WM1000), induration, bruising, tenderness, itching, edema, and erythema at the injection site (Grey Slate Natural Stacked Stone). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Semi Automatic Mec-08 Hydro-Pneumatic Self-Clinching Machine;Reusable Metal and Silicone Flexible Straw with Cleaning Brush and Case) and, in rare cases, necrosis or embolization might occur (Tri-Screw Extruder for Powder Coating;Sink Cupboard). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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