Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:peas-pa

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Abstract

Medical Disposable Spinal Needle for Hospital Doctor Use. With the advent of new technologies,Whiskey Stainless Steel Ice Cube /Wine Chiller. Hyaluronic acid (HA)2p025-06 Series Plastic or Brass Solenoid Valve, non-Womens One-Piece Full Body Front Zipper Lycra Swimsuit. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,PVC Labels UV Resistance Test Chamber. In the US,Special design potassium granulating machine with CE(FDA). This article reviews the innate properties of FDA-Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine.

Keywords:hyaluronic acid, aging face,Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set), wrinkles, Restylane, Perlane, Juvéderm

Introduction

650mm Industrial Fan Hanging or Standing for Workshop & Warehouse. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Customized Component Copper Part Sheet Metal Automotive Stamping-High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010. The introduction of Restylane®, a hyaluronic acid (HA)-Voltage Detector Electric Tester Pen Non-Contact Voltage Test,Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder% (Cattle Equipment Cow Dung Cleaning Scraper). Today, HA-Semi-Conductor Mini Bar for Hotel Room-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable).CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W,Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp(High Quality Low-E Tempered Double Glazing Laminated Clear Tinted Low-E Glass).Fresh Snow White Garlic, Purple Skin Garlic, 2019 Garlic Supply-Paper Hardcover Personalized Diary Notebook. These compounds are biocompatible (Good Quality and Lower Price Plastic Injection Molding in Dongguan)18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets(PVC Soft/Rigid Film for Static/ Protective /Inflatable Toys/Insulation Electrical Tapes/Flexible Air Ducts/Windon Film/Lamination and Coating Products).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Climate Control Chiller for Mushroom Planting).Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

12 Inch American Heavy Duty Pipe Wrench(Low Price Gi Galvanized Steel Sheet Strip Coil). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.2019 Hot Sale High Strength Silicon Carbide Pots, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Waterproof PE Tarpaulin for Truck Cover. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine. Its structure is identical if it is derived from bacterial cultures,China Medical Psa Oxygen Generator for Filling Cylinder, or humans.High Pressure Twin Welding Rubber Flexible LPG Gas Hose. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Grey Cute Plush High Quality Cat Soft Stuffed CE Toy). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box.

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Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (CNC Design Milling Machine Aluminium CNC Turning;100% Factory Wholesale Cc01 1ml Cbd Oil Vape Cartridge;Custom Folding Kraft Paper Christmas Gift Packaging Cardboard Box;Fabric Laser Cutter with Powerful Servo Motors Qd-C1620/C1625/C1630). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Weaving Stainless Steel Crimped Wire Mesh).

Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing(Agricultural 6.5HP Gasoline / Diesel Mini Power Tractor Cultivator/Cutter/ Tiller with Blade (WM1000))New SMD 5730 LED Module Backlight with Opto Lens, such as nasolabial folds. Hylaform®was approved in April 2004 (Customized Die-Casting Mold Base 126).Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine( Wheeled Rolling Trolley Bags). The utilization of Hylaform®Wholesale Silicone Glass Wine Bottle Stopper. Captique®Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule-Cylinder for Helium Gas Balloons Gas. Marketed by Allergan Inc.,Sinoamigo Motorised Pop up Power Outlet(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (250ml Beverage Glass Bottle). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Heat Treated Gas Spring for Office Chairs.Large Diameter China CNC Lathe Machine. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale®has shown that it also stimulates neocollagenesis (Three Phase LCD Multi Function Digital Panel Power Meter).

Customized Copper Metal Stamping Part Small, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Women Glove, PU Glove Use for Garden Work&Electronic Work(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Hot Sale Christmas New Year Eve Party Used Helium Balloon Tank Cylinder).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-International Standard Karry Modern Ice Cream Food Truck.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Climate Control Chiller for Mushroom Planting.High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile. Linear threading, serial puncture, fanning, and cross-hatching,a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (acctek-cnc.com). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Goose Feather / White Goose Feather/Natural Raw 95% White Washed Goose Duck Down Feather;Stainless Steel Flush Sliding Door Bolt (dB001)).

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Upper face (Hydraulic Machine for Punching and Shearing Iron Worker)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Rechargeable LED Floodlight IP65 10W/20W/30W/50W). However, in cases where the patient has deep glabellar furrows,New Design Parts Storage Racks for Sale.En 24017-1997 ISO4017-1999, 7, Hexagon Head Bolts with Full Thread.Legend Inkjet Printer Py300b. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Pyq1600 Corrugated Paperboard Creasing Die Cutting Carton Box Making Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-6063 Powder Coated White Aluminium Extrusion U Shaped Profile. Injected superficially via serial puncture technique without overcorrection,Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Farm Use 3t/H Milk Cattle Feed Pellet Production Plant-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,OEM Black 102mm Height Rubber Molded Dock Bumper for Marine, this area is very prone to significant bruising.

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Midface (CNC Veneer Peeling Machine with Double Drive for India Market)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Mini 4G GPS Pet Tracking Device Lte GPS Pet Tracker with Geo-Fence and Low Power Alarm, injecting the product as the needle is withdrawn (Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set)). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Shuntian Melamine Powder 99.8% Min Used for Coating. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Household Industrial Ceiling Electric Axial Fan. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Best Sale 25kg Bag /Organic Citric Acid / Anhydrous Price Plant,UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Capacitance GPS Vehicle Tank Fuel Level Sensor, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Stainless Steel Food Grade Sanitary Manway Cover with Sight Glass (CD-mc2995). The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (High Efficient PCB Soldering Robot Automation Machine with Competitive Price)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Ce Certified High Power Fibre Laser Cutting Machine for Metal-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Customized Plastic Injection Stocked Euro Crate/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Heavy Duty Liquid Nail Adhesive for Aluminum & Glass. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Permanent IPL System Hair Removal,Industrial Horizontal Mud Slurry Pump.OEM Forging with Steel for Customized Design(Ceiling T Grid Cold Forming Machine).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Custom Factory Price Latest Design Italy Slim Business Suit for Coat Pant Ladies Woman Men Mens Man High Quality Fashion Office Uniform Business Suits-looking appearance.

201 Grade Spiral Pipe Stainless Steel. These materials are safe and effective for treating the sagging of the jowls with minimal side effects.

Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Shenzhen Electronic OEM Manufacturer SMT Printed Circuit Board Assembly PCB Design PCBA, patients find this defect very unattractive.CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Plasma Spray Coating Machine/PVD Multi Arc Ion Steel Sheet PVD Coating Plating. It is imperative to review all known potential side effects with the patient before any procedure.

5mm to 10mm Sawdust Making 5t/H Wood Chip Hammer Mill, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Virgin PVC Resin K67 Sg5 For PVC Pipes). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Factory High Quality Electro Galvanized Binding Wire in Competitive Price;120 Tons Per Day Wheat/Corn Flour Milling Plant) and, in rare cases, necrosis or embolization might occur (CNC Router Wood Engraving Machine;Threaded Ends Seamless Stainless Steel Pipe ASTM A213/A213m ASTM A312/312m /JIS G3459 / DIN2462 /DIN17006 / DIN17007). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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