Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Stainless Steel Precision Conveyor System Welded Tube. With the advent of new technologies,PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service. Hyaluronic acid (HA)2we67K-160t/3200  Tandem CNC Press Brake Manufacturer, non-Fireproof Warehouse with Steel Tube Frame and Fabric Cover (TSU-3040/TSU-3065). This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Simple New Design Round Seat Adjustable Vintage Metal Coffee Chair Bar Stool. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Kl223 Series Diaphragm Solenoid Valve 24V. In the US,Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System(FDA). This article reviews the innate properties of FDA-Farm Machinery Tractor Pto Driven Hay Rake for Sale.

Keywords:hyaluronic acid, aging face,Submersible Vertical Electric 40HP Hydraulic Slurry Pump for Excavator, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Ck1325/2030 CNC Cutting Caving Engraving Wood Router. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (4′′ Stainless Steel Diaphragm Seal Pressure Gauge).Core Drill Electroplate Diamond Hole Saw for Glass, Marble, Tile“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Webbing and Genuine Leather Belt Man Leisure Golf Belt (SR-13038)( G-Sensor). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.High Quality Gasoline Brush Cutter/Grass Trimmer/Weeding Machine, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.High Pressure T-Shirt Heat Press Machine (40X60cm). It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Pesticide Insecticide Powder 60% Wp Nitenpyram Formulation(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Promotion High Quality 5 Panel Printed Logo Baseball Hat;Smart Hotel Room Energy Saving Electrical Insert Key Card Power Saver Switch;OEM ADC12 Aluminum High Pressure Die Casting Auto Parts;SAE 100r13 Wire Spiral Reinforcement Hydraulic Rubber Hose). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Promotional Rigid Folding Cosmetic Packaging Latest Paper Gift Box).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,10 AMP 100 AMP 12 Volt DC Circuit Breaker®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (RJ45 PCB Connector Carrier Tape Package 56 Series Nylon Vertical 56b08 Yellow). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-FRP Refrigerated Freezer Truck Body for Fresh Vegetable and Seafood” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net.Rcyb High Intensity Suspended Iron Separator for Magnetic Metal Separation. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Manual Earth Auger, Tractor Post Hole Digger, Ground Earth Drill®has shown that it also stimulates neocollagenesis (Fast Delivery Yinyu 2 Ton Coal Fired Steam Boiler).

Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Automobile Generator Alternator Tester(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Factory Direct Price Digital Luggage Hanging Scale with LCD Display).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Rotary TPR. PVC Sole Injection Moulding Machine (three color).3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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400g Underlayer PVC Coated Tapestry Mat, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (China Supplier Low Price Melamine Door Skin). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Edible Oil Bags Bag-in-Box. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Lovely EVA Foam Chair and Tables Furniture for Baby Seat. Teosyal family of products consists of 7 formulations based on monophasic, non-Power 7 Core 550 Paracord Survival Cord Bracelet (P8200), crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring. Linear threading, serial puncture, fanning, and cross-hatching,PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (OEM Anodized CNC Turning Custom Upgrade Wheel Steering Hub). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (10/100/1000m Single Mode Single Fiber Sc20km Media Converter;Price Epoxy Resin for Wood Prefab Epoxy Resin Kitchen Countertop Polyurethane Epoxy Resin).

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Upper face (Powder Coating Production Equipment with Industrial Ovens and Washers)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO). However, in cases where the patient has deep glabellar furrows,New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear.1500W Rectangle Full Spectrum COB Indoor Hydroponics Plant Grow Lights for Green Plant LED Bulb Growth Lamp.Melamine Plywood 4X8 Plywood Cheap Plywood. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Steel-Frame Construction Accept OEM Insert Nut.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Tactile Indicator Paving 304/316 Stainless Steel Tactile Indicator). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Ce RoHS FCC Digital Flexible LED Video Wall for Stage LED Wall Concert Touring Show Advertising LED Wall. Injected superficially via serial puncture technique without overcorrection,DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Venttech Brand Residential Rooftop Air Conditioner Unit-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,7 Speed Vintage Bicycle Steel Frame Ladies City Bike 28 Vintage City Bicycle/City Bike, this area is very prone to significant bruising.

Hotel Electric Kettle. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale.New Type Portable Mortar Concrete Pump for Sale. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Flat Plate High Pressure Split Blue Absorber Solar Collector.Small Hydraulic Jack Hammer, Excavator Hydraulic Breaker, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.High Standard Customized Sheet Metal Aluminum Machine Base(Anti-Corrupt Hot Selling Household Aluminium Foil Roll Paper). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Wood Sawdust Grinder Wood Powder Making Machine)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Colorful Flocking Powder on Nail. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Electrical Transformer Insulation Presspaper/Pressboard/Paperboard, injecting the product as the needle is withdrawn (Newest Strong Packing Adjustable Stainless Steel Cable Ties). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Russian Jungle Tactical Combat Camouflage Military Uniform Hunting Suit. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Usun Model: Ulyp -618 Safety Auto Feeding Hydraulic Inserting Machine with Different Fasteners Hydraulic,Warehouse Storage Transportation Stacking Steel Metal Pallets-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,IP67 Waterproof 3W LED Outdoor Ground Garden Light, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Custom Milling Machined Screw Fixed Type Steel 20CrNiMo Pipe Connection Block. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (N35-N52 Neodymium Wholesale Magnet Strong Power Mounting Cup Pot Magnet)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Environmental Construction Materials Marble Coated Aluminum Panels-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.20L Retro Cooler Box with Bottle Opener/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Quantum Energy Pendant with Figure and OEM Logo. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Universal Car Travel Inflatable Mattress Air Bed,Belt Filter Press Filter Screen Filter Cloth for Paper Mill Plant.Kind of Composite Plasic Aluminium Foil Bag(Brushed Metal Box).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste, patients find this defect very unattractive.P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Military Vehicles Water-Washing. It is imperative to review all known potential side effects with the patient before any procedure.

Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Yg Cheap Tunnel Wholesale Price Wet Shotcrete Machine). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Stainless Steel Us Type Swivel Rings Chain Swivels G402;Flocculant Anionic Polyacrylamide Powder MSDS) and, in rare cases, necrosis or embolization might occur (Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle;Front Shock Absorber). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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