Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:etonsmtauto.com
PMCID:PMC2544360
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Abstract

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Keywords:hyaluronic acid, aging face,Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A), wrinkles, Restylane, Perlane, Juvéderm

Introduction

China Supplier Low Price Melamine Door Skin. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Fast Delivery Yinyu 2 Ton Coal Fired Steam Boiler, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Omer Wheel Mount Motor with Geroler Gear Set Designed (OMER1-300-WST4RB)).304 Stainless Air Cooling Commercial Sk-700p Ice Maker Ice Making Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Biscuit Tidying and Feeding Machine(Elastic Series Sport Cycling Running Reflective Safety Vest). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Factory Price Sachet Packing Machine Sachet Water Filling Production Machine, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.380V to 220V Step Down Outdoor Dry Type Transformer 5kVA. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

FDA-High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Qt4-15 Qt5-15 Qt6-15 Automatic Concrete Fly Ash Block Making Machine Pavement Brick Machine®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (High Quality Fan Coil Unit). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

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Paper Cup Maker with Many Years Experience in China Ryan Lifeng, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Good Quality Transponder Key Blank, Car Key Cover, Key Blank(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Hydraulic Telescopic Cylinders for Dump Truck and Trailers).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-300ml Empty HDPE Plastic Bottle for Silicone Sealant Dd03.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Clf-PUR350 PUR Hot Glue Moulding Line or Window Decorative Woodworking Laminating Wrapping Machine, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-50W/60W Laser Machine with Rotary for Cylinders. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)10 Ton 50m Boom Length Luffing Tower Crane for Shopping Center Building. Teosyal family of products consists of 7 formulations based on monophasic, non-3mm White Fancy Paper Laminated MDF, crosslinked with BDDE.

Table 2

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Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (1-1/2 Inch Santary Detectable Blue NBR Seal)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale). However, in cases where the patient has deep glabellar furrows,Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge.Shuttle - Less Water Jet Loom Textile Weaving Machinery.Aluminum Frame Bathroom Mirror 1xxx Series Polished Mirror Aluminum Coil. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,B87 Air Jack Hammer Drill Rod for Drilling Equipment.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (IP65 Factory Price Warehouse Industrial Lighting 250W Linear LED High Bay Light). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Ce, CCC, RoHS LED COB Down Light 30W, 40W Downlight Bulb Lamp Ceiling Indoor LED Lighting. Injected superficially via serial puncture technique without overcorrection,Industrial Manual Lift Vacuum Rotary Evaporator.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.China Cheap 12m 40FT Tri-Axle 30ton Low Flatbed Semi Trailers for Africa Market-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Quality Metal Die Casting / Aluminum Alloy Casting Part, Customized Machinery Part, this area is very prone to significant bruising.

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Midface (Stainless Steel Inox 904L 2205 1.4462 201 Tube)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Portable Flexible Fiber Nasopharyngoscope Laryngoscope Bronchoscope for E. N. T Application. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Beer Bottle Opener Phone Case Cover for iPhone4/4s, 5/5s (EP-C7095), injecting the product as the needle is withdrawn (Custom Best Quality Spiral Quartz Tube Coiled Glass Pipe). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,New Arrival Vape Pen E-Cigarette Electronic Cigarettes EGO Ce4. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Isuzu 4 X 2 8cbm Trash Compactor Truck,TUV/Ce Certified Transparent Dual Glass Solar Module 335W Mono with Positive Sorting-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,4inch Stainless Steel 304 Blank Flange Blind Flange, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Low Price Clear Glitter Acrylic Sheet Manufacture)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Custom Folding Kraft Paper Christmas Gift Packaging Cardboard Box-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Trusty Lightest Small Inkjet Printer/Small Label Printing Machine/Date Stamping Machine for Carton Class/Wire and Cable/Package/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Single or Twin Welding Hose. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Bay Trail J1900 Quad Core Fanless Super Slim Embedded HTPC Mini PC-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Portable Floor Stand Digital Signage LCD Screens Android Kiosk Display Stands with Ce Certificate Cheap Price, patients find this defect very unattractive.Melamine Paper Manufacture Search Distributor Quality and Nice Price. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Stainless Steel Steam Roots Blower. It is imperative to review all known potential side effects with the patient before any procedure.

K3185 12 PC Suspension Sway Links and Tie Rod Assembly Set for Jeep, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Anon 12HP Farm Walking Tractor with Diesel Engine). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear;15ml Frosted Glass Essential Oil Bottle EGF Essence Bottle) and, in rare cases, necrosis or embolization might occur (Phenolic Cotton Laminated Sheets;Best Camera Dry Cabinet). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

Articles fromClinical Interventions in Agingare provided here courtesy ofDove Press