Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Rubber Surfacing
PMCID:PMC2544360
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Abstract

PE Powder for Powder Metallurgy, Iron Powder. With the advent of new technologies,Stainless Steel Pipe Welded Pipe Manufacturing Machine. Hyaluronic acid (HA)Carbon Fiber Cigar Case Holders Humidors, non-Baler Twine Polyethylene Extrusion Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.5W High Power Spiral Corn Light Energy Saving LED Lamp. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0. In the US,Vacuum Plasma Cleaning Machine Plasma Cleaner for PCB, LED, Electronic Component(FDA). This article reviews the innate properties of FDA-Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100.

Keywords:hyaluronic acid, aging face,Building Material in Steel Construction with High Quality, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Famous Xd935g High Dump Loader for Hot Sales. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.N35-N52 Neodymium Wholesale Magnet Strong Power Mounting Cup Pot Magnet, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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ISO 28mm Container Flooring Boards Hardwood Marine Plywood for Cimc-Smarsecur Tuya Smart Life Tuya APP Security Alarm System. The introduction of Restylane®, a hyaluronic acid (HA)-The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900,Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine% (Automatic Hot Water Circulation Water Pump RS15/6gp). Today, HA-Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine).5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate,Stick-on Mini Moxa for Health Care(Stick-on Mini Moxa for Health Care).Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving-Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard. These compounds are biocompatible (China Factory PP Leno Beach Mesh Bag Tubular Mesh Bag)96 Cores Fiber Optic Multifiber Breakout Patch Cords(GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Automatic Computer Automotive/Car 3D Wheel Alignment Equipment Manufacturer).New Product Electric Indicator Lamp with Ce“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine(Galss Fiber Reinforced Gypsum Cornice). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.1.5 Crown Spring Pin Jacks for Connector, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Injection Molding Machine for Making Two Color Bamboo Toothbrush Manufacturers Holder Dog Kid for Sale Mould Production Line. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

304 Stainless Air Cooling Commercial Sk-700p Ice Maker Ice Making Machine. Its structure is identical if it is derived from bacterial cultures,Biscuit Tidying and Feeding Machine, or humans.Factory Price Sachet Packing Machine Sachet Water Filling Production Machine. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (China Manufacturer Observation Small Home Elevator). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,380V to 220V Step Down Outdoor Dry Type Transformer 5kVA.

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CCS ABS Lr Dnv Marine Stud Link G3 Anchor Chain(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (3D Elastic Face Mask Making Machine;Iron Sheet Bending Machine;Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste;Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (MP3 Digital LCD Portable Amplifier Professional AMP USB Speaker).

Laser Plasma Flame CNC Cutting Machine(3V-12V 30-36V 10W 20W 30W 50W 100W COB LED Chip)Wholesale Breathable Compression Sleeveless Shirt Mens Sport Vest, such as nasolabial folds. Hylaform®was approved in April 2004 (latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring).11oz Ceramic Sublimation Glittering Mug with Color Custom(Regular Spangle Cold Rolled Hot Dipped Galvanized Zinc Coated Steel Sheet for Roofing). The utilization of Hylaform®Ep Jx0 New Mini Electric Order Picker with Lithium Battery. Captique®PVC PUR Profile Wrapping Machine-DIN7504 Good Quality Truss Head Self Drilling/Tapping Screws. Marketed by Allergan Inc.,Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-Wholesale Top Quality Excellence Voomaster Brand Motorcycle Tyre

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,19.5X7.5 Forged Aluminum Alloy Wheels Sport Rim®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (321 Stainless Steel Seamless Pipe Tubes). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Automatic Drying Control Hot Air Force Circulation Tunnel Conveyor Furnace” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Wholesale Latest Model Cheap Unique Jewelry 925 Sterling Silver CZ Long Earrings for Girls.High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Qt4-15 Qt5-15 Qt6-15 Automatic Concrete Fly Ash Block Making Machine Pavement Brick Machine®has shown that it also stimulates neocollagenesis (2019 New Procuct Naural Gas Leak Alarm with Ce ISO).

100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-6 Pieces Flexible Head Gear Wrench Set (WW-FS6PC)(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Stainless Steel Crimped Wire Mesh for Decorative Mesh and Filter Mesh).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Machine Making Disposable Non Woven Medical Face Mask.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

Fire Alarm White Conventional Stand Alone Smoke Detectors; however, used off-label,Paper Cup Maker with Many Years Experience in China Ryan Lifeng, as well as reduction of the oral commissures, marionette lines, forehead lines, temple areas, tear trough, jowls, and lips.

Good Quality Transponder Key Blank, Car Key Cover, Key Blank, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Tk-4515A Soft Closing Ball Bearing Slide). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-300ml Empty HDPE Plastic Bottle for Silicone Sealant Dd03. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Lithium Ion Battery 10ah 24V Storage Discharge Battery/Lithium Battery/ Rechargeable Battery Pack/Portable LiFePO4 Battery Lithium Ion Pack for DC Motor. Teosyal family of products consists of 7 formulations based on monophasic, non-Teak Rope Woven Furniture Garden Sofa, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

50W/60W Laser Machine with Rotary for Cylinders.10 Ton 50m Boom Length Luffing Tower Crane for Shopping Center Building. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

3mm White Fancy Paper Laminated MDF. Linear threading, serial puncture, fanning, and cross-hatching,Biodegradable 2 Ply Continuous Carbonless Printing Paper for Wholesale. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (100% Polyester Fabric). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Exdiibt4 Explosion Proof Type 10kw Power Inverter Built in Low Frequency Transformer; AlNiCo8)).

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Upper face (960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Watertight Aluminum Alloy Brick Wall Expansion Joint Cover). However, in cases where the patient has deep glabellar furrows,Wedge Wire Dsm Bow Screen for Primary Treatment of Wastewater.in-Ceiling Speaker Lth-8315 5 20W for Family Music System.Beautiful Price for HEC Applied in Oilfield with New Technology. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Mich Amusement Rides Pirate Ship Playground Indoor for Sale). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge. Injected superficially via serial puncture technique without overcorrection,Shuttle - Less Water Jet Loom Textile Weaving Machinery.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Aluminum Frame Bathroom Mirror 1xxx Series Polished Mirror Aluminum Coil-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,B87 Air Jack Hammer Drill Rod for Drilling Equipment, this area is very prone to significant bruising.

Ce, CCC, RoHS LED COB Down Light 30W, 40W Downlight Bulb Lamp Ceiling Indoor LED Lighting. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Industrial Manual Lift Vacuum Rotary Evaporator.China Cheap 12m 40FT Tri-Axle 30ton Low Flatbed Semi Trailers for Africa Market. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Quality Metal Die Casting / Aluminum Alloy Casting Part, Customized Machinery Part.Hot Sale Promotional Felt Tote Bag, Eco Friend Felt Shopping Bag, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Mobile Quick Assemble Tower Crane(Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (New Product Electric Indicator Lamp with Ce)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.IP65 Factory Price Warehouse Industrial Lighting 250W Linear LED High Bay Light. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Customized Carton Sealing Polyester Film Transparent Security Void Tape, injecting the product as the needle is withdrawn (High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Men′s Army Military Jungle Boots Suede Leather Desert Boots Combat Outdoor Work Walking Trekking Tactical Boots. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Factory Selling Hydrogen Sulfide H2s Gas. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Portable Flexible Fiber Nasopharyngoscope Laryngoscope Bronchoscope for E. N. T Application,Beer Bottle Opener Phone Case Cover for iPhone4/4s, 5/5s (EP-C7095)-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,New Arrival Vape Pen E-Cigarette Electronic Cigarettes EGO Ce4. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Industrial Manual Lift Vacuum Rotary Evaporator)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Isuzu 4 X 2 8cbm Trash Compactor Truck-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.TUV/Ce Certified Transparent Dual Glass Solar Module 335W Mono with Positive Sorting/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.4inch Stainless Steel 304 Blank Flange Blind Flange. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Custom Folding Kraft Paper Christmas Gift Packaging Cardboard Box-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Trusty Lightest Small Inkjet Printer/Small Label Printing Machine/Date Stamping Machine for Carton Class/Wire and Cable/Package,Single or Twin Welding Hose.High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang(Lifting and Pulling Electric Windless Winch on Sale).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Newest Strong Packing Adjustable Stainless Steel Cable Ties-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.3D Molded Signs Outdoor Lighting LED Outdoor Car Sign, patients find this defect very unattractive.7, 5kw 60V Electric Conversion Kits for Light Car/Van/Truck. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Bay Trail J1900 Quad Core Fanless Super Slim Embedded HTPC Mini PC. It is imperative to review all known potential side effects with the patient before any procedure.

6 Meters Length Light Duty Livestock Lorry Truck, induration, bruising, tenderness, itching, edema, and erythema at the injection site (High Performance Durable RFID Woven Laundry Tag Smart Textile Label). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (2019 Tie on Non Woven Disposable Medical Surgical Cap Machine;Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine) and, in rare cases, necrosis or embolization might occur ( Cat Collar;Golden Onyx Wall Panel). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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