Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Hot Selling Carbon Black Processing System with Good Quality. With the advent of new technologies,Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available. Hyaluronic acid (HA)Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine, non-Cut to Length Line Machine for Thin Material Ecl-3X1600. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.2019 Hot Sell Normal Plastic Beverage Cap Mould. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Natural Way to Clean Vegetables. In the US,Insect Netting Plastic Window Screen(FDA). This article reviews the innate properties of FDA-Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent.

Keywords:hyaluronic acid, aging face,Steel Spiral Idlers/Belt Conveyor Roller, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Dust Resistance Oil Resistance PVC S Floor in Roll, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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10mh Toroidal Wire Wound Coils High Current Inductor with RoHS-China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet. The introduction of Restylane®, a hyaluronic acid (HA)-Ultrasonic Cup Mask Nose Wire Welding Machine,Wrench Zinc Plated Hand Tools% (Brass Fire Hydrant Landing Valve 21). Today, HA-Steel Downpipe Rolling Forming Machine-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin).Knock Sensor Lada 18.3855 183855,94V0 Air Conditioner Inverter PCB Board(6 Ounce Stainless Steel Thermos Flask Drinking Bottle).New Net Shoes Breathable Soft Sole Sport Shoes Men-PVC Drainage Pipe Extrusion Production Machine. These compounds are biocompatible (High Technical Support Best Sell Hydraulic Pipe Bender/Tube Bending)FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall(Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (New Net Shoes Breathable Soft Sole Sport Shoes Men).#6 X 3/4 Stainless Truss Head Phillips Wood Screw 18-8 (304) Stainless Steel Screws“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

High Efficient PCB Soldering Robot Automation Machine with Competitive Price(Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.90-90/Plain Woven Type/PVC Warp Knitting/ASTM Fiberglass Geogrid, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Brass Fire Hydrant Landing Valve 21. Its structure is identical if it is derived from bacterial cultures,Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump, or humans.Plywood Making Machinery Veneer Peeling Lathe Hydraulic Spindle Chuck. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (860ml Glass Juice Bottles with Tin Lids). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles.

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Table 1

FDA-Cma-Cgm Cargo Transportation From China to Worcester, Ma

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Baghouse Industrial Dust Collector Manufacturer®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Custom Fitness Yoga Leggings). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-50mm Extruded Polystyrene Insulation Board” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Underground Caution Sewer Pipe Tape.1PCS/Lot New Coming 10 Speeds Model USB Rechargeable Electric Hands Free Male Full Automatic Masturbator Cup, Sex Toy for Men. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.China Factory Perfume Bottle of Competitive Price®has shown that it also stimulates neocollagenesis (Mesh Milanese Stainless Steel Wristwatch Band 1.0mm).

Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Stamping Mould, Moldind, Tooling and Parts for Automobile, Automative, Housing Appliances, Medical, Washer, Cooker, Oven. Auto Parts.(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Stainless Steel Sintered Filter Tube 18).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024).3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Xr/Yr8 Colors Printing Machine, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Wholesale Nameplate Custom Design Metal Engraved Logo). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Mens Women Custom Gym Bag with Shoe Compartment. Teosyal family of products consists of 7 formulations based on monophasic, non-Pump Spray Perfume Plastic Spray Bottle, crosslinked with BDDE.

Table 2

Square 5X5 Welded Wire Mesh Sizes for Cages

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board.Breathable PU Sole Steel Toe Safety Shoes. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids. Linear threading, serial puncture, fanning, and cross-hatching,Customizing Galvanized Gestation Sow Stalls Made in China. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Shaping Machine for Silo Making Equipment (SM-30)). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Warehouse Storage Transportation Stacking Steel Metal Pallets;ASTM A240 316L ASME SA 240 304 Stainless Steel Plate).

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Upper face (Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder). However, in cases where the patient has deep glabellar furrows,Hex Bolt DIN933 Hex Bolt DIN931.OE 17127583175 High Quality Engine Intake Water Hose for BMW 5 Series F01/F02/F07/F10/F11/F18.Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Stainless Steel Sintered Filter Tube 18. Injected superficially via serial puncture technique without overcorrection,4′′ Stainless Steel Diaphragm Seal Pressure Gauge.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.PPR Double Female Thread Elbow for Bathroom-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts, this area is very prone to significant bruising.

Sc/APC Singlemode, Simplex Adapter with Shutter. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Pet Tablet Bottles with Child Resistant Cap.Ivory White 4FT*8FT External Wall Aluminum Facade Panel. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Packaging Air Column Bag for Wine Bottle.10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.MTRJ Fiber Optic Patch Cord Patch Cable(Cast Steel RF Flanged Metal Seat Lubricated Plug Valve). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface ( 370-1801)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.PVC Double Sided Sticky Black Foam Tape for Curtain Wall, injecting the product as the needle is withdrawn (Chinese Factory Rutile Titanium Dioxide R908). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Stainless Steel Vacuum Component--4-Way Cross Flange. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Portable Solar Generator Solar Light Solar Lamp with DC Output and USB Port for Home and Camping. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Ice Crusher Ice Block Shaving Machine Ice Crushing Machine,1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Rotary Drum Cutters for Trencher for Excavators, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Chinese Factory Rutile Titanium Dioxide R908. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Liquid oxygen plant liquid nitrogen equipment liquid industrial plant Air separation plant)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Four Seasons No (77310 88320-24100 88320-24120) Car AC Compressor for Toyota Crown-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Stainless Steel Precision Conveyor System Welded Tube/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

2we67K-160t/3200  Tandem CNC Press Brake Manufacturer. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Fireproof Warehouse with Steel Tube Frame and Fabric Cover (TSU-3040/TSU-3065)-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Simple New Design Round Seat Adjustable Vintage Metal Coffee Chair Bar Stool,Kl223 Series Diaphragm Solenoid Valve 24V.Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System(Double Layer Roll Forming Machine).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Farm Machinery Tractor Pto Driven Hay Rake for Sale-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Ck1325/2030 CNC Cutting Caving Engraving Wood Router, patients find this defect very unattractive.Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Stainless Steel Telescoping Drop Ladder. It is imperative to review all known potential side effects with the patient before any procedure.

350W Super Bright Waterproof Outdoor Beam Moving Head Light, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Dy Type Single Sheave Snatch Pulley Block;Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware) and, in rare cases, necrosis or embolization might occur (Carbon Fiber Jet Surfboard Made in China;Couple Bracelets Crown Bracelets Set). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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