Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Phenolic Cotton Laminated Sheets. With the advent of new technologies,12V 300mm Plastic Radiator Condenser Fan for Beach Buggy. Hyaluronic acid (HA)Passenger Elevator Lift with Vvvf Drive, non-DIN41612 Right Angle Dual Row Plug, B Shell. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Teflon Rotay/Shaft Seals for Hydraulic Cylinder. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Zjt Impact Resistance Lightweight Sandwich Panel. In the US,Customized Component Copper Part Sheet Metal Automotive Stamping(FDA). This article reviews the innate properties of FDA-High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010.

Keywords:hyaluronic acid, aging face,Voltage Detector Electric Tester Pen Non-Contact Voltage Test, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Semi-Conductor Mini Bar for Hotel Room, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine-Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner. The introduction of Restylane®, a hyaluronic acid (HA)-12 Inch American Heavy Duty Pipe Wrench,2019 Hot Sale High Strength Silicon Carbide Pots% (China Medical Psa Oxygen Generator for Filling Cylinder). Today, HA-Waterproof PE Tarpaulin for Truck Cover-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (201/202/301/304/316 Stainless Steel Sheet/Plate/Coil/Pipe).Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine,China Medical Psa Oxygen Generator for Filling Cylinder(Dog Pet Shock Absorber Tension Spring).High Pressure Twin Welding Rubber Flexible LPG Gas Hose-Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box. These compounds are biocompatible (Wire Screw Needle)High Quality DTH Button Drill Bits for Mining Machine(Industrial Horizontal Mud Slurry Pump).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Medium Grade Q245 Q235B Carbon Steel Checkered Plate 6mm Thick).Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Wholesale Silicone Glass Wine Bottle Stopper. Its structure is identical if it is derived from bacterial cultures,Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule, or humans.Cylinder for Helium Gas Balloons Gas. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Parker Standard Hydraulic Hose Reusable Fittings). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Sinoamigo Motorised Pop up Power Outlet.

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Table 1

FDA-Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Bulk Pharmaceutical Grade Hyaluronic Acid Supplier & Manufacturer). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Washroom Sanitary Ware Shower Taps Set with Watermark Certification.Climate Control Chiller for Mushroom Planting. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine®has shown that it also stimulates neocollagenesis (150L American Style Two Tiers Big Capacity Metal Shopping Cart).

Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Neck Pillow Massager U Shaped Slow Rebound Memory Foam).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Flocculant Anionic Polyacrylamide Powder MSDS.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Automatic Door Closer Cylinder Hydraulic Floor Spring, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Medical Use Coated Aluminum Foil Paper). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-20W 30W Fiber Laser Marking Machine for Chip Industry Surface Treatment. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)New Design Parts Storage Racks for Sale. Teosyal family of products consists of 7 formulations based on monophasic, non-En 24017-1997 ISO4017-1999, 7, Hexagon Head Bolts with Full Thread, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying. Linear threading, serial puncture, fanning, and cross-hatching,Farm Use 3t/H Milk Cattle Feed Pellet Production Plant. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Tapered Equipment). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans;Environmentally Friendly Car Wash Equipment Car Wash Mobile Equipment).

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Upper face (Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket). However, in cases where the patient has deep glabellar furrows,6063 Aluminium Alloy Wooden Color Aluminum Tube.Waterproof Colorful FDA Approved Non Anti Slip Eco-Friendly Silicone Placemat.Organic Water Soluble Granular Humic Acid 80% Long Term Fertilizer. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (130 AMP Air Inverter Plasma Cutter with Ce). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Mini 4G GPS Pet Tracking Device Lte GPS Pet Tracker with Geo-Fence and Low Power Alarm. Injected superficially via serial puncture technique without overcorrection,Shuntian Melamine Powder 99.8% Min Used for Coating.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Household Industrial Ceiling Electric Axial Fan-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Best Sale 25kg Bag /Organic Citric Acid / Anhydrous Price Plant, this area is very prone to significant bruising.

UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface ( 500ml)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.China High Quality PVC Galvanized Barbed Wire for Sale. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Permanent IPL System Hair Removal, injecting the product as the needle is withdrawn (Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Industrial Horizontal Mud Slurry Pump. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,OEM Forging with Steel for Customized Design. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Custom Factory Price Latest Design Italy Slim Business Suit for Coat Pant Ladies Woman Men Mens Man High Quality Fashion Office Uniform Business Suits,201 Grade Spiral Pipe Stainless Steel-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Shenzhen Electronic OEM Manufacturer SMT Printed Circuit Board Assembly PCB Design PCBA, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (High Efficiency Carton and Corrugated Box Gluing Machine (GK-1100GS))

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Plasma Spray Coating Machine/PVD Multi Arc Ion Steel Sheet PVD Coating Plating-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.5mm to 10mm Sawdust Making 5t/H Wood Chip Hammer Mill/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Supply Custom Stamping Challenge Souvenir Old Coincustom Art Metal Enamel Souvenir Challenge Coin (469). This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Quad Seal Snack Food Coffee Bag 350g 400g 450g 500g Coffee Packaging Bag with E-Zipper and Valve. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Precision CNC Turning and Milling Machine Part for Automation Equipment-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Du Dx Tin Platting Metal-Polymer Composite Oilless Bearing Bushing).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.High Strength Factory Directly Supply DIN603 Carriage Bolts,1-1/2 Inch Santary Detectable Blue NBR Seal.CNC Fiber Laser 2000 Watt Cutting Machine for Stainless Steel, Aluminum, Alloy with 2 Years Warranty(Clear Acrylic Pipe).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Professional Flexible Aluminum Floor Trim Extrusion Profile Supplier-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Metal Lantern LED String Lights and bulb, patients find this defect very unattractive.Pocketable Logo Special Cheap Designer Gift Retractable Mini Badge Reels Punching Card for Promotional Gift. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Bed Sheet Bedding Set Inflight Quilt Supplier  Quilt  Mat. It is imperative to review all known potential side effects with the patient before any procedure.

China Supplier Sheet Metal Stamping Electrical Parts with Powder Coating, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Wholesale Supply Packaging Shrink Wrap PE Film Biodegradable Stretch Film). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (5t/24h to 2000t/24h Maize Machine;Square Flanged Unit Ucf215-215 Cast Housing Set Screw Type) and, in rare cases, necrosis or embolization might occur (Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light;Thin Blade Slitter And Scorer). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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