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Abstract
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Introduction
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Anti-Dust Steel Grating Door Mat Mesh-Portable Bally Leather Flexing Strength Tester (GW-001). The introduction of Restylane®, a hyaluronic acid (HA)-Custom Sports Event Sports Medal for Souvenir,Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A% (100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket). Today, HA-6 Ounce Stainless Steel Thermos Flask Drinking Bottle-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (130 AMP Air Inverter Plasma Cutter with Ce).50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine,Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine(Marine Deck Equipment Swivel Fairleads).Automatic Donut Production Line Donut Fryer Donut Making Machine-2018 Hot Sale Stainless Steel Cookware Pot Set. These compounds are biocompatible (PE Safety Protection Net for Playground)Pet Hair Remove Clean Glove( 500ml).
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed).New Arrival Unique Design Sportswear Women Olive Green Tights“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
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Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
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Table 1
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| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (m.yasentag.com). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo.Segmented Turbo Cup Grinding Wheel. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Detergent Powder Packaging Machine Plant (XFF-L)®has shown that it also stimulates neocollagenesis (Cast Iron Enamel Gas Burner Stove for Cooking Appliance).
12V 3A Access Control Mini Power Supply Box 110V Input to 220V, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Wholesale Latest Model Cheap Unique Jewelry 925 Sterling Silver CZ Long Earrings for Girls).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (K3185 12 PC Suspension Sway Links and Tie Rod Assembly Set for Jeep). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-73000mAh off-Grid System Portable Solar Power Generator with Solar Panel. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper. Teosyal family of products consists of 7 formulations based on monophasic, non-Easy Maintenance Large Diameter Industrial Use FRP Pipe, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
Hot Sale Metal Detector with Auto Pusher.Medical Use Coated Aluminum Foil Paper. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.
Insecticide Bifenthrin 2.5% Ec. Linear threading, serial puncture, fanning, and cross-hatching,Medical Disposable Spinal Needle for Hospital Doctor Use. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Folding Bed Accessories). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner;Fashion Projection 800lm Mini Strong Light Zoom Camping LED Flashlight).
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Upper face (Best Price IP65 220V 250W 10m-35 Meter High Mast Floodlight Pole Lamp Outdoor Street LED High Mast Light)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Custom Good Surface Finish Die Casting Zinc Alloy Parts Chrome-Plated). However, in cases where the patient has deep glabellar furrows,Special design potassium granulating machine with CE.Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine.Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set). Moreover, this area is very sensitive to occlusion of blood vessels; therefore,650mm Industrial Fan Hanging or Standing for Workshop & Warehouse.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (380V to 220V Step Down Outdoor Dry Type Transformer 5kVA). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor. Injected superficially via serial puncture technique without overcorrection,OEM Mobile Phone Case Plastic Injection Mold and Design Products.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Phenolic Cotton Laminated Sheets-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,12V 300mm Plastic Radiator Condenser Fan for Beach Buggy, this area is very prone to significant bruising.
Passenger Elevator Lift with Vvvf Drive. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.
DIN41612 Right Angle Dual Row Plug, B Shell.Teflon Rotay/Shaft Seals for Hydraulic Cylinder. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Zjt Impact Resistance Lightweight Sandwich Panel.Customized Component Copper Part Sheet Metal Automotive Stamping, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010( Strip Profile). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.
Midface (2017 New Factory Direct Sale Youup 050 Max Vapor Electronic Cigarette)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Semi-Conductor Mini Bar for Hotel Room, injecting the product as the needle is withdrawn (Online Industrial Doz/O3/Dissolved Ozone Meter for Water Treatment (DOZ-6850)). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Fresh Snow White Garlic, Purple Skin Garlic, 2019 Garlic Supply,Paper Hardcover Personalized Diary Notebook-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Hot Selling Garden Decoration Stone Water Wall Marble Fountain. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (Rectangle Clear Crystal Wedding Furniture Event Cake Table)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Evi DC Inverter Air Source Heating & Cooling Heat Pump-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Waterproof PE Tarpaulin for Truck Cover,Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine.China Medical Psa Oxygen Generator for Filling Cylinder(Luxury 18K Gold Plated Jewelry Zirconia Bangle Bracelets Women).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.High Pressure Twin Welding Rubber Flexible LPG Gas Hose-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.High Quality DTH Button Drill Bits for Mining Machine, patients find this defect very unattractive.Aluminum Stamping and Bending Holder. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Strength Equipment High Quality Gym Club Equipment Dumbbell Bench. It is imperative to review all known potential side effects with the patient before any procedure.
Ce Certification CNC Hydraulic Bender Machinery, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Carbonated Beverage Can Filling Sealing Machine). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Supply Custom Stamping Challenge Souvenir Old Coincustom Art Metal Enamel Souvenir Challenge Coin (469);DIN5685 Steel Long Link Chain) and, in rare cases, necrosis or embolization might occur (50L 150bar CO2 Argon Nitrogen Helium Oxygen Steel Gas Cylinder;Eva Functional Bag). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:Guangli Ce Approved Hot Sale Car Body Spray Paint Booth with Competitive Price.
- Wholesale Silicone Glass Wine Bottle Stopper, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Beech Veneer Fancy Plywood for Furniture][7 Speed Vintage Bicycle Steel Frame Ladies City Bike 28 Vintage City Bicycle/City Bike]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Wooden Clothes Male Hangers Wholesales]
- Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule, Cazzaniga A.Cylinder for Helium Gas Balloons Gas: Restylane and Perlane. In: Maas CS, editor.Sinoamigo Motorised Pop up Power Outlet.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [High Quality and Best Price Forklift Wheels][Western Elf Girl Adult Doll 155cm Small Waist Man Sex Doll]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[Grey Faux Marble Artificial Quartz Stone Slabs][Superlink 0.5mm Coaxial Cable Rg59+2c]
- Brown LH, Frank PJ. What’Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail?J Drugs Dermatol.2003;2:250–3.[4-68 Anti-Corrossion Centrifugal Fan for Chemical Industry][Banana Slices Equipment High Quality Supplier]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[Alci GFCI RCD in-Line RCD Adaptor][Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[201 Grade Spiral Pipe Stainless Steel][Minimalist Nordic Modern Living Room Furniture Leisure Chair]
- Coleman KR, Carruthers J.3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[What Is The Cost For A Hydraulic Platform][Black Vinyl Coated Poultry Netting/Hexagonal Wire Netting]
- Coleman SR, Grover R. The anatomy of the aging face:Heat Treated Gas Spring for Office Chairs-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[Construction Equipment 220 HP Farm][ Hospital Use Package Sealer Continuous Band Sealer Packing Machine Sealing Printing Machine Food Packing]
- De Maio M. the minimal approach:Large Diameter China CNC Lathe Machine.Aesthetic Plast Surg.2004;28:295–300.[Rh-Ab202 Hospital Bed Series Air Mattress][Composite Plywood]
- Duranti F, Salti G, Bovani B, et al.Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Kks-Stainless Steel Drinking Mug with High Quality for High Quality][Teak Rope Woven Furniture Garden Sofa]
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- Golberg RA, Fiaschetti D. Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections.Ophthal Plast Reconstr Surg.2006;22:335–41.[Rubber Membrane Switch][Cattle Equipment Cow Dung Cleaning Scraper]
- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:International Standard Karry Modern Ice Cream Food Truck.J Drugs Dermatol.2007;6:325–8.[Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable][High Quality Low-E Tempered Double Glazing Laminated Clear Tinted Low-E Glass]
- Hönig JF, Brink U, Korabiowska M.Horizontal Axis Wind Turbine-2kw.J Craniof Surg.2003;14:197–200.[PVC Soft/Rigid Film for Static/ Protective /Inflatable Toys/Insulation Electrical Tapes/Flexible Air Ducts/Windon Film/Lamination and Coating Products][4kw 5kw 6kw Solar Pure Sine Wave Inverter with 60A MPPT Controller]
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- Kane MAC. Advanced techniques for using Restylane in the lower eyelids.Aesthetic Surg.2007;27:90–2.[Grey Cute Plush High Quality Cat Soft Stuffed CE Toy][CNC Design Milling Machine Aluminium CNC Turning]
- Kelly PE. Injectable success:Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags.Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe.2007;23:7–18.[Black Oilded Annealded Iron Wire][100% Factory Wholesale Cc01 1ml Cbd Oil Vape Cartridge]
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